Note
Go to the end to download the full example code.
Preclinical - reproducibility of hepatocellular function#
This example illustrates the use of Liver for fitting of signals
measured in liver. The use case is provided by the liver work package of the
TRISTAN project which develops imaging
biomarkers for drug safety assessment. The data and analysis were first
published in Gunwhy et al. (2024).
The specific objective of the study was to to identify the main sources of variability in DCE-MRI biomarkers of hepatocellular function in rats. This was done by comparing data measured at different centres and field strengths, at different days in the same subjects, and over the course of several months in the same centre.
The study presented here measured gadoxetate uptake and excretion in healthy rats either scanned once with vehicle or twice with either vehicle or 10 mg/kg of rifampicin at follow-up. Studies were performed in preclinical MRI scanners at 3 different centers and 2 different field strengths. Results demonstrated significant differences between substudies for uptake and excretion. Within-subject differences were substantially smaller for excretion but less so for uptake. Rifampicin-induced inhibition was safely above the detection limits for both uptake and excretion. Most of the variability in individual data was accounted for by between-subject and between-centre variability, substantially more than the between-day variation. Significant differences in excretion were observed between field strengths at the same centre, between centres at the same field strength, and between repeat experiments over 2 months apart in the same centre.
Reference
Gunwhy ER, Hines CDG, Green C, Laitinen I, Tadimalla S, Hockings PD, Schütz G, Kenna JG, Sourbron S, Waterton JC. Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study. MAGMA. 2024 Aug;37(4):697-708. [DOI]
Setup#
# Import packages
import pandas as pd
import numpy as np
import matplotlib.pyplot as plt
import seaborn as sns
import dcmri as dc
# Fetch the data
data = dc.fetch('tristan_repro')
Model definition#
In order to avoid some repetition in this script, we define a function that returns a trained model for a single dataset.
The model uses a standardized, population-average input function and fits for only 2 parameters, fixing all other free parameters to typical values for this rat model:
def tristan_rat(data, **kwargs):
# High-resolution time points for prediction
t = np.arange(0, np.amax(data['time'])+0.5, 0.5)
# Standard input function
ca = dc.aif_tristan_rat(t, BAT=data['BAT'], duration=data['duration'])
# Liver model with population input function
model = dc.Liver(
# Input parameters
t = t,
ca = ca,
# Acquisition parameters
field_strength = data['field_strength'],
agent = 'gadoxetate',
TR = data['TR'],
FA = data['FA'],
n0 = data['n0'],
# Kinetic paramaters
kinetics = '1I-IC-HF',
H = 0.418,
ve = 0.23,
Fp = 0.022019, # mL/sec/cm3
free = {
'khe': [0, np.inf],
'Th': [0, np.inf],
},
# Tissue paramaters
R10 = 1/dc.T1(data['field_strength'], 'liver'),
)
return model.train(data['time'], data['liver'], **kwargs)
Check model fit#
Before running the full analysis on all cases, lets illustrate the results by fitting the baseline visit for the first subject. We use maximum verbosity to get some feedback about the iterations:
model = tristan_rat(data[0], xtol=1e-3, verbose=2)
Iteration Total nfev Cost Cost reduction Step norm Optimality
0 1 1.1223e+02 2.78e+04
1 3 5.7756e+01 5.45e+01 4.50e+02 4.47e+03
2 5 4.8000e+01 9.76e+00 3.37e+02 2.26e+03
3 6 3.6639e+01 1.14e+01 5.84e+02 7.38e+03
4 7 1.8168e+01 1.85e+01 3.67e+01 7.55e+02
5 8 1.5501e+01 2.67e+00 1.23e+02 1.51e+03
6 9 1.3877e+01 1.62e+00 1.55e+00 2.54e+01
7 10 1.3876e+01 4.86e-04 1.43e-02 1.95e-02
`xtol` termination condition is satisfied.
Function evaluations 10, initial cost 1.1223e+02, final cost 1.3876e+01, first-order optimality 1.95e-02.
Plot the results to check that the model has fitted the data:
Print the measured model parameters and any derived parameters and check that standard deviations of measured parameters are small relative to the value, indicating that the parameters are measured reliably:
model.print_params(round_to=3)
--------------------------------
Free parameters with their stdev
--------------------------------
Hepatocellular uptake rate (khe): 0.023 (0.003) mL/sec/cm3
Hepatocellular mean transit time (Th): 266.901 (33.958) sec
----------------------------
Fixed and derived parameters
----------------------------
Hematocrit (H): 0.418
Liver extracellular volume fraction (ve): 0.23 mL/cm3
Biliary tissue excretion rate (Kbh): 0.004 mL/sec/cm3
Hepatocellular tissue uptake rate (Khe): 0.099 mL/sec/cm3
Biliary excretion rate (kbh): 0.003 mL/sec/cm3
Liver extraction fraction (E): 0.508
Hepatic plasma clearance (Ktrans): 0.011 mL/sec/cm3
Fit all data#
Now that we have illustrated an individual result in some detail, we proceed with fitting all the data. Results are stored in a dataframe in long format:
results = []
# Loop over all datasets
for scan in data:
# Generate a trained model for scan i:
model = tristan_rat(scan, xtol=1e-3)
# Save fitted parameters as a dataframe.
pars = model.export_params()
pars = pd.DataFrame.from_dict(pars,
orient = 'index',
columns = ["name", "value", "unit", 'stdev'])
pars['parameter'] = pars.index
pars['study'] = scan['study']
pars['visit'] = scan['visit']
pars['subject'] = scan['subject']
# Add the dataframe to the list of results
results.append(pars)
# Combine all results into a single dataframe.
results = pd.concat(results).reset_index(drop=True)
# Print all results
print(results.to_string())
name value unit stdev parameter study visit subject
0 Hematocrit 0.418000 0.000000 H 1 1 1
1 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 1
2 Hepatocellular uptake rate 0.022701 mL/sec/cm3 0.002651 khe 1 1 1
3 Hepatocellular mean transit time 266.901064 sec 33.957856 Th 1 1 1
4 Biliary tissue excretion rate 0.003747 mL/sec/cm3 0.000000 Kbh 1 1 1
5 Hepatocellular tissue uptake rate 0.098699 mL/sec/cm3 0.000000 Khe 1 1 1
6 Biliary excretion rate 0.002885 mL/sec/cm3 0.000000 kbh 1 1 1
7 Liver extraction fraction 0.507622 0.000000 E 1 1 1
8 Hepatic plasma clearance 0.011177 mL/sec/cm3 0.000000 Ktrans 1 1 1
9 Hematocrit 0.418000 0.000000 H 1 2 1
10 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 1
11 Hepatocellular uptake rate 0.020918 mL/sec/cm3 0.003735 khe 1 2 1
12 Hepatocellular mean transit time 243.879773 sec 47.254760 Th 1 2 1
13 Biliary tissue excretion rate 0.004100 mL/sec/cm3 0.000000 Kbh 1 2 1
14 Hepatocellular tissue uptake rate 0.090949 mL/sec/cm3 0.000000 Khe 1 2 1
15 Biliary excretion rate 0.003157 mL/sec/cm3 0.000000 kbh 1 2 1
16 Liver extraction fraction 0.487183 0.000000 E 1 2 1
17 Hepatic plasma clearance 0.010727 mL/sec/cm3 0.000000 Ktrans 1 2 1
18 Hematocrit 0.418000 0.000000 H 1 1 2
19 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 2
20 Hepatocellular uptake rate 0.023369 mL/sec/cm3 0.002335 khe 1 1 2
21 Hepatocellular mean transit time 260.154158 sec 28.196566 Th 1 1 2
22 Biliary tissue excretion rate 0.003844 mL/sec/cm3 0.000000 Kbh 1 1 2
23 Hepatocellular tissue uptake rate 0.101603 mL/sec/cm3 0.000000 Khe 1 1 2
24 Biliary excretion rate 0.002960 mL/sec/cm3 0.000000 kbh 1 1 2
25 Liver extraction fraction 0.514869 0.000000 E 1 1 2
26 Hepatic plasma clearance 0.011337 mL/sec/cm3 0.000000 Ktrans 1 1 2
27 Hematocrit 0.418000 0.000000 H 1 2 2
28 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 2
29 Hepatocellular uptake rate 0.022508 mL/sec/cm3 0.002475 khe 1 2 2
30 Hepatocellular mean transit time 261.093933 sec 31.218844 Th 1 2 2
31 Biliary tissue excretion rate 0.003830 mL/sec/cm3 0.000000 Kbh 1 2 2
32 Hepatocellular tissue uptake rate 0.097860 mL/sec/cm3 0.000000 Khe 1 2 2
33 Biliary excretion rate 0.002949 mL/sec/cm3 0.000000 kbh 1 2 2
34 Liver extraction fraction 0.505490 0.000000 E 1 2 2
35 Hepatic plasma clearance 0.011130 mL/sec/cm3 0.000000 Ktrans 1 2 2
36 Hematocrit 0.418000 0.000000 H 1 1 3
37 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 3
38 Hepatocellular uptake rate 0.020732 mL/sec/cm3 0.001915 khe 1 1 3
39 Hepatocellular mean transit time 255.544433 sec 25.731754 Th 1 1 3
40 Biliary tissue excretion rate 0.003913 mL/sec/cm3 0.000000 Kbh 1 1 3
41 Hepatocellular tissue uptake rate 0.090140 mL/sec/cm3 0.000000 Khe 1 1 3
42 Biliary excretion rate 0.003013 mL/sec/cm3 0.000000 kbh 1 1 3
43 Liver extraction fraction 0.484950 0.000000 E 1 1 3
44 Hepatic plasma clearance 0.010678 mL/sec/cm3 0.000000 Ktrans 1 1 3
45 Hematocrit 0.418000 0.000000 H 1 2 3
46 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 3
47 Hepatocellular uptake rate 0.017791 mL/sec/cm3 0.000773 khe 1 2 3
48 Hepatocellular mean transit time 392.098904 sec 20.157139 Th 1 2 3
49 Biliary tissue excretion rate 0.002550 mL/sec/cm3 0.000000 Kbh 1 2 3
50 Hepatocellular tissue uptake rate 0.077352 mL/sec/cm3 0.000000 Khe 1 2 3
51 Biliary excretion rate 0.001964 mL/sec/cm3 0.000000 kbh 1 2 3
52 Liver extraction fraction 0.446896 0.000000 E 1 2 3
53 Hepatic plasma clearance 0.009840 mL/sec/cm3 0.000000 Ktrans 1 2 3
54 Hematocrit 0.418000 0.000000 H 1 1 4
55 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 4
56 Hepatocellular uptake rate 0.011437 mL/sec/cm3 0.001050 khe 1 1 4
57 Hepatocellular mean transit time 409.157248 sec 45.720199 Th 1 1 4
58 Biliary tissue excretion rate 0.002444 mL/sec/cm3 0.000000 Kbh 1 1 4
59 Hepatocellular tissue uptake rate 0.049726 mL/sec/cm3 0.000000 Khe 1 1 4
60 Biliary excretion rate 0.001882 mL/sec/cm3 0.000000 kbh 1 1 4
61 Liver extraction fraction 0.341853 0.000000 E 1 1 4
62 Hepatic plasma clearance 0.007527 mL/sec/cm3 0.000000 Ktrans 1 1 4
63 Hematocrit 0.418000 0.000000 H 1 2 4
64 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 4
65 Hepatocellular uptake rate 0.006051 mL/sec/cm3 0.000481 khe 1 2 4
66 Hepatocellular mean transit time 712.406726 sec 88.350553 Th 1 2 4
67 Biliary tissue excretion rate 0.001404 mL/sec/cm3 0.000000 Kbh 1 2 4
68 Hepatocellular tissue uptake rate 0.026308 mL/sec/cm3 0.000000 Khe 1 2 4
69 Biliary excretion rate 0.001081 mL/sec/cm3 0.000000 kbh 1 2 4
70 Liver extraction fraction 0.215562 0.000000 E 1 2 4
71 Hepatic plasma clearance 0.004746 mL/sec/cm3 0.000000 Ktrans 1 2 4
72 Hematocrit 0.418000 0.000000 H 1 1 5
73 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 5
74 Hepatocellular uptake rate 0.024691 mL/sec/cm3 0.003274 khe 1 1 5
75 Hepatocellular mean transit time 207.612963 sec 29.316346 Th 1 1 5
76 Biliary tissue excretion rate 0.004817 mL/sec/cm3 0.000000 Kbh 1 1 5
77 Hepatocellular tissue uptake rate 0.107352 mL/sec/cm3 0.000000 Khe 1 1 5
78 Biliary excretion rate 0.003709 mL/sec/cm3 0.000000 kbh 1 1 5
79 Liver extraction fraction 0.528601 0.000000 E 1 1 5
80 Hepatic plasma clearance 0.011639 mL/sec/cm3 0.000000 Ktrans 1 1 5
81 Hematocrit 0.418000 0.000000 H 1 2 5
82 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 5
83 Hepatocellular uptake rate 0.002797 mL/sec/cm3 0.000424 khe 1 2 5
84 Hepatocellular mean transit time 737.024993 sec 178.889125 Th 1 2 5
85 Biliary tissue excretion rate 0.001357 mL/sec/cm3 0.000000 Kbh 1 2 5
86 Hepatocellular tissue uptake rate 0.012161 mL/sec/cm3 0.000000 Khe 1 2 5
87 Biliary excretion rate 0.001045 mL/sec/cm3 0.000000 kbh 1 2 5
88 Liver extraction fraction 0.112714 0.000000 E 1 2 5
89 Hepatic plasma clearance 0.002482 mL/sec/cm3 0.000000 Ktrans 1 2 5
90 Hematocrit 0.418000 0.000000 H 1 1 6
91 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 1 6
92 Hepatocellular uptake rate 0.020065 mL/sec/cm3 0.002657 khe 1 1 6
93 Hepatocellular mean transit time 235.655481 sec 33.845440 Th 1 1 6
94 Biliary tissue excretion rate 0.004243 mL/sec/cm3 0.000000 Kbh 1 1 6
95 Hepatocellular tissue uptake rate 0.087239 mL/sec/cm3 0.000000 Khe 1 1 6
96 Biliary excretion rate 0.003267 mL/sec/cm3 0.000000 kbh 1 1 6
97 Liver extraction fraction 0.476784 0.000000 E 1 1 6
98 Hepatic plasma clearance 0.010498 mL/sec/cm3 0.000000 Ktrans 1 1 6
99 Hematocrit 0.418000 0.000000 H 1 2 6
100 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 1 2 6
101 Hepatocellular uptake rate 0.004232 mL/sec/cm3 0.000535 khe 1 2 6
102 Hepatocellular mean transit time 570.914481 sec 101.110539 Th 1 2 6
103 Biliary tissue excretion rate 0.001752 mL/sec/cm3 0.000000 Kbh 1 2 6
104 Hepatocellular tissue uptake rate 0.018401 mL/sec/cm3 0.000000 Khe 1 2 6
105 Biliary excretion rate 0.001349 mL/sec/cm3 0.000000 kbh 1 2 6
106 Liver extraction fraction 0.161218 0.000000 E 1 2 6
107 Hepatic plasma clearance 0.003550 mL/sec/cm3 0.000000 Ktrans 1 2 6
108 Hematocrit 0.418000 0.000000 H 2 1 1
109 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 1
110 Hepatocellular uptake rate 0.037553 mL/sec/cm3 0.002281 khe 2 1 1
111 Hepatocellular mean transit time 262.914010 sec 17.072280 Th 2 1 1
112 Biliary tissue excretion rate 0.003804 mL/sec/cm3 0.000000 Kbh 2 1 1
113 Hepatocellular tissue uptake rate 0.163274 mL/sec/cm3 0.000000 Khe 2 1 1
114 Biliary excretion rate 0.002929 mL/sec/cm3 0.000000 kbh 2 1 1
115 Liver extraction fraction 0.630380 0.000000 E 2 1 1
116 Hepatic plasma clearance 0.013880 mL/sec/cm3 0.000000 Ktrans 2 1 1
117 Hematocrit 0.418000 0.000000 H 2 2 1
118 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 1
119 Hepatocellular uptake rate 0.009112 mL/sec/cm3 0.000716 khe 2 2 1
120 Hepatocellular mean transit time 272.981659 sec 24.397678 Th 2 2 1
121 Biliary tissue excretion rate 0.003663 mL/sec/cm3 0.000000 Kbh 2 2 1
122 Hepatocellular tissue uptake rate 0.039617 mL/sec/cm3 0.000000 Khe 2 2 1
123 Biliary excretion rate 0.002821 mL/sec/cm3 0.000000 kbh 2 2 1
124 Liver extraction fraction 0.292696 0.000000 E 2 2 1
125 Hepatic plasma clearance 0.006445 mL/sec/cm3 0.000000 Ktrans 2 2 1
126 Hematocrit 0.418000 0.000000 H 2 1 2
127 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 2
128 Hepatocellular uptake rate 0.046339 mL/sec/cm3 0.006089 khe 2 1 2
129 Hepatocellular mean transit time 144.489242 sec 19.573871 Th 2 1 2
130 Biliary tissue excretion rate 0.006921 mL/sec/cm3 0.000000 Kbh 2 1 2
131 Hepatocellular tissue uptake rate 0.201472 mL/sec/cm3 0.000000 Khe 2 1 2
132 Biliary excretion rate 0.005329 mL/sec/cm3 0.000000 kbh 2 1 2
133 Liver extraction fraction 0.677885 0.000000 E 2 1 2
134 Hepatic plasma clearance 0.014926 mL/sec/cm3 0.000000 Ktrans 2 1 2
135 Hematocrit 0.418000 0.000000 H 2 2 2
136 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 2
137 Hepatocellular uptake rate 0.026788 mL/sec/cm3 0.001283 khe 2 2 2
138 Hepatocellular mean transit time 268.125043 sec 14.044691 Th 2 2 2
139 Biliary tissue excretion rate 0.003730 mL/sec/cm3 0.000000 Kbh 2 2 2
140 Hepatocellular tissue uptake rate 0.116470 mL/sec/cm3 0.000000 Khe 2 2 2
141 Biliary excretion rate 0.002872 mL/sec/cm3 0.000000 kbh 2 2 2
142 Liver extraction fraction 0.548856 0.000000 E 2 2 2
143 Hepatic plasma clearance 0.012085 mL/sec/cm3 0.000000 Ktrans 2 2 2
144 Hematocrit 0.418000 0.000000 H 2 1 3
145 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 3
146 Hepatocellular uptake rate 0.042612 mL/sec/cm3 0.003651 khe 2 1 3
147 Hepatocellular mean transit time 155.287619 sec 13.798939 Th 2 1 3
148 Biliary tissue excretion rate 0.006440 mL/sec/cm3 0.000000 Kbh 2 1 3
149 Hepatocellular tissue uptake rate 0.185268 mL/sec/cm3 0.000000 Khe 2 1 3
150 Biliary excretion rate 0.004959 mL/sec/cm3 0.000000 kbh 2 1 3
151 Liver extraction fraction 0.659310 0.000000 E 2 1 3
152 Hepatic plasma clearance 0.014517 mL/sec/cm3 0.000000 Ktrans 2 1 3
153 Hematocrit 0.418000 0.000000 H 2 2 3
154 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 3
155 Hepatocellular uptake rate 0.029486 mL/sec/cm3 0.002314 khe 2 2 3
156 Hepatocellular mean transit time 166.931971 sec 13.883798 Th 2 2 3
157 Biliary tissue excretion rate 0.005990 mL/sec/cm3 0.000000 Kbh 2 2 3
158 Hepatocellular tissue uptake rate 0.128199 mL/sec/cm3 0.000000 Khe 2 2 3
159 Biliary excretion rate 0.004613 mL/sec/cm3 0.000000 kbh 2 2 3
160 Liver extraction fraction 0.572485 0.000000 E 2 2 3
161 Hepatic plasma clearance 0.012606 mL/sec/cm3 0.000000 Ktrans 2 2 3
162 Hematocrit 0.418000 0.000000 H 2 1 4
163 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 4
164 Hepatocellular uptake rate 0.024529 mL/sec/cm3 0.001685 khe 2 1 4
165 Hepatocellular mean transit time 176.772736 sec 12.998496 Th 2 1 4
166 Biliary tissue excretion rate 0.005657 mL/sec/cm3 0.000000 Kbh 2 1 4
167 Hepatocellular tissue uptake rate 0.106649 mL/sec/cm3 0.000000 Khe 2 1 4
168 Biliary excretion rate 0.004356 mL/sec/cm3 0.000000 kbh 2 1 4
169 Liver extraction fraction 0.526963 0.000000 E 2 1 4
170 Hepatic plasma clearance 0.011603 mL/sec/cm3 0.000000 Ktrans 2 1 4
171 Hematocrit 0.418000 0.000000 H 2 2 4
172 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 4
173 Hepatocellular uptake rate 0.002012 mL/sec/cm3 0.000273 khe 2 2 4
174 Hepatocellular mean transit time 665.775347 sec 137.384826 Th 2 2 4
175 Biliary tissue excretion rate 0.001502 mL/sec/cm3 0.000000 Kbh 2 2 4
176 Hepatocellular tissue uptake rate 0.008747 mL/sec/cm3 0.000000 Khe 2 2 4
177 Biliary excretion rate 0.001157 mL/sec/cm3 0.000000 kbh 2 2 4
178 Liver extraction fraction 0.083720 0.000000 E 2 2 4
179 Hepatic plasma clearance 0.001843 mL/sec/cm3 0.000000 Ktrans 2 2 4
180 Hematocrit 0.418000 0.000000 H 2 1 5
181 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 5
182 Hepatocellular uptake rate 0.015487 mL/sec/cm3 0.001692 khe 2 1 5
183 Hepatocellular mean transit time 137.937824 sec 16.288495 Th 2 1 5
184 Biliary tissue excretion rate 0.007250 mL/sec/cm3 0.000000 Kbh 2 1 5
185 Hepatocellular tissue uptake rate 0.067334 mL/sec/cm3 0.000000 Khe 2 1 5
186 Biliary excretion rate 0.005582 mL/sec/cm3 0.000000 kbh 2 1 5
187 Liver extraction fraction 0.412917 0.000000 E 2 1 5
188 Hepatic plasma clearance 0.009092 mL/sec/cm3 0.000000 Ktrans 2 1 5
189 Hematocrit 0.418000 0.000000 H 2 2 5
190 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 5
191 Hepatocellular uptake rate 0.005127 mL/sec/cm3 0.000557 khe 2 2 5
192 Hepatocellular mean transit time 446.263349 sec 61.828233 Th 2 2 5
193 Biliary tissue excretion rate 0.002241 mL/sec/cm3 0.000000 Kbh 2 2 5
194 Hepatocellular tissue uptake rate 0.022292 mL/sec/cm3 0.000000 Khe 2 2 5
195 Biliary excretion rate 0.001725 mL/sec/cm3 0.000000 kbh 2 2 5
196 Liver extraction fraction 0.188871 0.000000 E 2 2 5
197 Hepatic plasma clearance 0.004159 mL/sec/cm3 0.000000 Ktrans 2 2 5
198 Hematocrit 0.418000 0.000000 H 2 1 6
199 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 1 6
200 Hepatocellular uptake rate 0.024838 mL/sec/cm3 0.001156 khe 2 1 6
201 Hepatocellular mean transit time 273.362928 sec 13.997410 Th 2 1 6
202 Biliary tissue excretion rate 0.003658 mL/sec/cm3 0.000000 Kbh 2 1 6
203 Hepatocellular tissue uptake rate 0.107989 mL/sec/cm3 0.000000 Khe 2 1 6
204 Biliary excretion rate 0.002817 mL/sec/cm3 0.000000 kbh 2 1 6
205 Liver extraction fraction 0.530077 0.000000 E 2 1 6
206 Hepatic plasma clearance 0.011672 mL/sec/cm3 0.000000 Ktrans 2 1 6
207 Hematocrit 0.418000 0.000000 H 2 2 6
208 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 2 2 6
209 Hepatocellular uptake rate 0.005436 mL/sec/cm3 0.000346 khe 2 2 6
210 Hepatocellular mean transit time 521.114358 sec 44.688732 Th 2 2 6
211 Biliary tissue excretion rate 0.001919 mL/sec/cm3 0.000000 Kbh 2 2 6
212 Hepatocellular tissue uptake rate 0.023633 mL/sec/cm3 0.000000 Khe 2 2 6
213 Biliary excretion rate 0.001478 mL/sec/cm3 0.000000 kbh 2 2 6
214 Liver extraction fraction 0.197984 0.000000 E 2 2 6
215 Hepatic plasma clearance 0.004359 mL/sec/cm3 0.000000 Ktrans 2 2 6
216 Hematocrit 0.418000 0.000000 H 3 1 1
217 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 1
218 Hepatocellular uptake rate 0.024023 mL/sec/cm3 0.001109 khe 3 1 1
219 Hepatocellular mean transit time 312.195533 sec 16.179354 Th 3 1 1
220 Biliary tissue excretion rate 0.003203 mL/sec/cm3 0.000000 Kbh 3 1 1
221 Hepatocellular tissue uptake rate 0.104449 mL/sec/cm3 0.000000 Khe 3 1 1
222 Biliary excretion rate 0.002466 mL/sec/cm3 0.000000 kbh 3 1 1
223 Liver extraction fraction 0.521766 0.000000 E 3 1 1
224 Hepatic plasma clearance 0.011489 mL/sec/cm3 0.000000 Ktrans 3 1 1
225 Hematocrit 0.418000 0.000000 H 3 2 1
226 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 1
227 Hepatocellular uptake rate 0.034071 mL/sec/cm3 0.002178 khe 3 2 1
228 Hepatocellular mean transit time 229.896375 sec 15.643979 Th 3 2 1
229 Biliary tissue excretion rate 0.004350 mL/sec/cm3 0.000000 Kbh 3 2 1
230 Hepatocellular tissue uptake rate 0.148137 mL/sec/cm3 0.000000 Khe 3 2 1
231 Biliary excretion rate 0.003349 mL/sec/cm3 0.000000 kbh 3 2 1
232 Liver extraction fraction 0.607438 0.000000 E 3 2 1
233 Hepatic plasma clearance 0.013375 mL/sec/cm3 0.000000 Ktrans 3 2 1
234 Hematocrit 0.418000 0.000000 H 3 1 2
235 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 2
236 Hepatocellular uptake rate 0.027256 mL/sec/cm3 0.001718 khe 3 1 2
237 Hepatocellular mean transit time 320.467865 sec 22.611328 Th 3 1 2
238 Biliary tissue excretion rate 0.003120 mL/sec/cm3 0.000000 Kbh 3 1 2
239 Hepatocellular tissue uptake rate 0.118505 mL/sec/cm3 0.000000 Khe 3 1 2
240 Biliary excretion rate 0.002403 mL/sec/cm3 0.000000 kbh 3 1 2
241 Liver extraction fraction 0.553141 0.000000 E 3 1 2
242 Hepatic plasma clearance 0.012180 mL/sec/cm3 0.000000 Ktrans 3 1 2
243 Hematocrit 0.418000 0.000000 H 3 2 2
244 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 2
245 Hepatocellular uptake rate 0.018993 mL/sec/cm3 0.002042 khe 3 2 2
246 Hepatocellular mean transit time 383.292674 sec 48.765401 Th 3 2 2
247 Biliary tissue excretion rate 0.002609 mL/sec/cm3 0.000000 Kbh 3 2 2
248 Hepatocellular tissue uptake rate 0.082578 mL/sec/cm3 0.000000 Khe 3 2 2
249 Biliary excretion rate 0.002009 mL/sec/cm3 0.000000 kbh 3 2 2
250 Liver extraction fraction 0.463107 0.000000 E 3 2 2
251 Hepatic plasma clearance 0.010197 mL/sec/cm3 0.000000 Ktrans 3 2 2
252 Hematocrit 0.418000 0.000000 H 3 1 3
253 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 3
254 Hepatocellular uptake rate 0.021736 mL/sec/cm3 0.000685 khe 3 1 3
255 Hepatocellular mean transit time 320.805579 sec 11.449094 Th 3 1 3
256 Biliary tissue excretion rate 0.003117 mL/sec/cm3 0.000000 Kbh 3 1 3
257 Hepatocellular tissue uptake rate 0.094503 mL/sec/cm3 0.000000 Khe 3 1 3
258 Biliary excretion rate 0.002400 mL/sec/cm3 0.000000 kbh 3 1 3
259 Liver extraction fraction 0.496764 0.000000 E 3 1 3
260 Hepatic plasma clearance 0.010938 mL/sec/cm3 0.000000 Ktrans 3 1 3
261 Hematocrit 0.418000 0.000000 H 3 2 3
262 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 3
263 Hepatocellular uptake rate 0.017769 mL/sec/cm3 0.001324 khe 3 2 3
264 Hepatocellular mean transit time 276.567242 sec 23.043210 Th 3 2 3
265 Biliary tissue excretion rate 0.003616 mL/sec/cm3 0.000000 Kbh 3 2 3
266 Hepatocellular tissue uptake rate 0.077258 mL/sec/cm3 0.000000 Khe 3 2 3
267 Biliary excretion rate 0.002784 mL/sec/cm3 0.000000 kbh 3 2 3
268 Liver extraction fraction 0.446596 0.000000 E 3 2 3
269 Hepatic plasma clearance 0.009834 mL/sec/cm3 0.000000 Ktrans 3 2 3
270 Hematocrit 0.418000 0.000000 H 3 1 4
271 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 4
272 Hepatocellular uptake rate 0.034191 mL/sec/cm3 0.002869 khe 3 1 4
273 Hepatocellular mean transit time 281.281632 sec 25.575679 Th 3 1 4
274 Biliary tissue excretion rate 0.003555 mL/sec/cm3 0.000000 Kbh 3 1 4
275 Hepatocellular tissue uptake rate 0.148656 mL/sec/cm3 0.000000 Khe 3 1 4
276 Biliary excretion rate 0.002737 mL/sec/cm3 0.000000 kbh 3 1 4
277 Liver extraction fraction 0.608271 0.000000 E 3 1 4
278 Hepatic plasma clearance 0.013394 mL/sec/cm3 0.000000 Ktrans 3 1 4
279 Hematocrit 0.418000 0.000000 H 3 2 4
280 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 4
281 Hepatocellular uptake rate 0.000882 mL/sec/cm3 0.000113 khe 3 2 4
282 Hepatocellular mean transit time 65625.454312 sec 242620.440873 Th 3 2 4
283 Biliary tissue excretion rate 0.000015 mL/sec/cm3 0.000000 Kbh 3 2 4
284 Hepatocellular tissue uptake rate 0.003837 mL/sec/cm3 0.000000 Khe 3 2 4
285 Biliary excretion rate 0.000012 mL/sec/cm3 0.000000 kbh 3 2 4
286 Liver extraction fraction 0.038533 0.000000 E 3 2 4
287 Hepatic plasma clearance 0.000848 mL/sec/cm3 0.000000 Ktrans 3 2 4
288 Hematocrit 0.418000 0.000000 H 3 1 5
289 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 5
290 Hepatocellular uptake rate 0.019442 mL/sec/cm3 0.001310 khe 3 1 5
291 Hepatocellular mean transit time 273.275488 sec 20.847519 Th 3 1 5
292 Biliary tissue excretion rate 0.003659 mL/sec/cm3 0.000000 Kbh 3 1 5
293 Hepatocellular tissue uptake rate 0.084532 mL/sec/cm3 0.000000 Khe 3 1 5
294 Biliary excretion rate 0.002818 mL/sec/cm3 0.000000 kbh 3 1 5
295 Liver extraction fraction 0.468929 0.000000 E 3 1 5
296 Hepatic plasma clearance 0.010325 mL/sec/cm3 0.000000 Ktrans 3 1 5
297 Hematocrit 0.418000 0.000000 H 3 2 5
298 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 5
299 Hepatocellular uptake rate 0.002662 mL/sec/cm3 0.000265 khe 3 2 5
300 Hepatocellular mean transit time 2096.750917 sec 748.034858 Th 3 2 5
301 Biliary tissue excretion rate 0.000477 mL/sec/cm3 0.000000 Kbh 3 2 5
302 Hepatocellular tissue uptake rate 0.011575 mL/sec/cm3 0.000000 Khe 3 2 5
303 Biliary excretion rate 0.000367 mL/sec/cm3 0.000000 kbh 3 2 5
304 Liver extraction fraction 0.107865 0.000000 E 3 2 5
305 Hepatic plasma clearance 0.002375 mL/sec/cm3 0.000000 Ktrans 3 2 5
306 Hematocrit 0.418000 0.000000 H 3 1 6
307 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 1 6
308 Hepatocellular uptake rate 0.018851 mL/sec/cm3 0.001438 khe 3 1 6
309 Hepatocellular mean transit time 361.106760 sec 33.865350 Th 3 1 6
310 Biliary tissue excretion rate 0.002769 mL/sec/cm3 0.000000 Kbh 3 1 6
311 Hepatocellular tissue uptake rate 0.081959 mL/sec/cm3 0.000000 Khe 3 1 6
312 Biliary excretion rate 0.002132 mL/sec/cm3 0.000000 kbh 3 1 6
313 Liver extraction fraction 0.461238 0.000000 E 3 1 6
314 Hepatic plasma clearance 0.010156 mL/sec/cm3 0.000000 Ktrans 3 1 6
315 Hematocrit 0.418000 0.000000 H 3 2 6
316 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 3 2 6
317 Hepatocellular uptake rate 0.002589 mL/sec/cm3 0.000266 khe 3 2 6
318 Hepatocellular mean transit time 1829.494917 sec 578.840780 Th 3 2 6
319 Biliary tissue excretion rate 0.000547 mL/sec/cm3 0.000000 Kbh 3 2 6
320 Hepatocellular tissue uptake rate 0.011257 mL/sec/cm3 0.000000 Khe 3 2 6
321 Biliary excretion rate 0.000421 mL/sec/cm3 0.000000 kbh 3 2 6
322 Liver extraction fraction 0.105215 0.000000 E 3 2 6
323 Hepatic plasma clearance 0.002317 mL/sec/cm3 0.000000 Ktrans 3 2 6
324 Hematocrit 0.418000 0.000000 H 4 1 1
325 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 1
326 Hepatocellular uptake rate 0.020679 mL/sec/cm3 0.001289 khe 4 1 1
327 Hepatocellular mean transit time 301.166410 sec 20.836217 Th 4 1 1
328 Biliary tissue excretion rate 0.003320 mL/sec/cm3 0.000000 Kbh 4 1 1
329 Hepatocellular tissue uptake rate 0.089909 mL/sec/cm3 0.000000 Khe 4 1 1
330 Biliary excretion rate 0.002557 mL/sec/cm3 0.000000 kbh 4 1 1
331 Liver extraction fraction 0.484309 0.000000 E 4 1 1
332 Hepatic plasma clearance 0.010664 mL/sec/cm3 0.000000 Ktrans 4 1 1
333 Hematocrit 0.418000 0.000000 H 4 2 1
334 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 1
335 Hepatocellular uptake rate 0.025041 mL/sec/cm3 0.001390 khe 4 2 1
336 Hepatocellular mean transit time 395.811923 sec 25.537122 Th 4 2 1
337 Biliary tissue excretion rate 0.002526 mL/sec/cm3 0.000000 Kbh 4 2 1
338 Hepatocellular tissue uptake rate 0.108874 mL/sec/cm3 0.000000 Khe 4 2 1
339 Biliary excretion rate 0.001945 mL/sec/cm3 0.000000 kbh 4 2 1
340 Liver extraction fraction 0.532108 0.000000 E 4 2 1
341 Hepatic plasma clearance 0.011716 mL/sec/cm3 0.000000 Ktrans 4 2 1
342 Hematocrit 0.418000 0.000000 H 4 1 2
343 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 2
344 Hepatocellular uptake rate 0.018306 mL/sec/cm3 0.001540 khe 4 1 2
345 Hepatocellular mean transit time 274.999596 sec 25.530787 Th 4 1 2
346 Biliary tissue excretion rate 0.003636 mL/sec/cm3 0.000000 Kbh 4 1 2
347 Hepatocellular tissue uptake rate 0.079591 mL/sec/cm3 0.000000 Khe 4 1 2
348 Biliary excretion rate 0.002800 mL/sec/cm3 0.000000 kbh 4 1 2
349 Liver extraction fraction 0.453961 0.000000 E 4 1 2
350 Hepatic plasma clearance 0.009996 mL/sec/cm3 0.000000 Ktrans 4 1 2
351 Hematocrit 0.418000 0.000000 H 4 2 2
352 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 2
353 Hepatocellular uptake rate 0.025679 mL/sec/cm3 0.001795 khe 4 2 2
354 Hepatocellular mean transit time 215.892033 sec 16.038397 Th 4 2 2
355 Biliary tissue excretion rate 0.004632 mL/sec/cm3 0.000000 Kbh 4 2 2
356 Hepatocellular tissue uptake rate 0.111647 mL/sec/cm3 0.000000 Khe 4 2 2
357 Biliary excretion rate 0.003567 mL/sec/cm3 0.000000 kbh 4 2 2
358 Liver extraction fraction 0.538365 0.000000 E 4 2 2
359 Hepatic plasma clearance 0.011854 mL/sec/cm3 0.000000 Ktrans 4 2 2
360 Hematocrit 0.418000 0.000000 H 4 1 3
361 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 3
362 Hepatocellular uptake rate 0.030104 mL/sec/cm3 0.002602 khe 4 1 3
363 Hepatocellular mean transit time 166.642085 sec 15.038239 Th 4 1 3
364 Biliary tissue excretion rate 0.006001 mL/sec/cm3 0.000000 Kbh 4 1 3
365 Hepatocellular tissue uptake rate 0.130887 mL/sec/cm3 0.000000 Khe 4 1 3
366 Biliary excretion rate 0.004621 mL/sec/cm3 0.000000 kbh 4 1 3
367 Liver extraction fraction 0.577556 0.000000 E 4 1 3
368 Hepatic plasma clearance 0.012717 mL/sec/cm3 0.000000 Ktrans 4 1 3
369 Hematocrit 0.418000 0.000000 H 4 2 3
370 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 3
371 Hepatocellular uptake rate 0.031763 mL/sec/cm3 0.002446 khe 4 2 3
372 Hepatocellular mean transit time 201.235422 sec 16.207187 Th 4 2 3
373 Biliary tissue excretion rate 0.004969 mL/sec/cm3 0.000000 Kbh 4 2 3
374 Hepatocellular tissue uptake rate 0.138099 mL/sec/cm3 0.000000 Khe 4 2 3
375 Biliary excretion rate 0.003826 mL/sec/cm3 0.000000 kbh 4 2 3
376 Liver extraction fraction 0.590586 0.000000 E 4 2 3
377 Hepatic plasma clearance 0.013004 mL/sec/cm3 0.000000 Ktrans 4 2 3
378 Hematocrit 0.418000 0.000000 H 4 1 4
379 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 4
380 Hepatocellular uptake rate 0.024781 mL/sec/cm3 0.001929 khe 4 1 4
381 Hepatocellular mean transit time 215.455531 sec 17.860634 Th 4 1 4
382 Biliary tissue excretion rate 0.004641 mL/sec/cm3 0.000000 Kbh 4 1 4
383 Hepatocellular tissue uptake rate 0.107745 mL/sec/cm3 0.000000 Khe 4 1 4
384 Biliary excretion rate 0.003574 mL/sec/cm3 0.000000 kbh 4 1 4
385 Liver extraction fraction 0.529513 0.000000 E 4 1 4
386 Hepatic plasma clearance 0.011659 mL/sec/cm3 0.000000 Ktrans 4 1 4
387 Hematocrit 0.418000 0.000000 H 4 2 4
388 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 4
389 Hepatocellular uptake rate 0.031542 mL/sec/cm3 0.001530 khe 4 2 4
390 Hepatocellular mean transit time 221.315703 sec 11.280667 Th 4 2 4
391 Biliary tissue excretion rate 0.004518 mL/sec/cm3 0.000000 Kbh 4 2 4
392 Hepatocellular tissue uptake rate 0.137139 mL/sec/cm3 0.000000 Khe 4 2 4
393 Biliary excretion rate 0.003479 mL/sec/cm3 0.000000 kbh 4 2 4
394 Liver extraction fraction 0.588899 0.000000 E 4 2 4
395 Hepatic plasma clearance 0.012967 mL/sec/cm3 0.000000 Ktrans 4 2 4
396 Hematocrit 0.418000 0.000000 H 4 1 5
397 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 5
398 Hepatocellular uptake rate 0.023245 mL/sec/cm3 0.001360 khe 4 1 5
399 Hepatocellular mean transit time 318.561744 sec 20.737505 Th 4 1 5
400 Biliary tissue excretion rate 0.003139 mL/sec/cm3 0.000000 Kbh 4 1 5
401 Hepatocellular tissue uptake rate 0.101067 mL/sec/cm3 0.000000 Khe 4 1 5
402 Biliary excretion rate 0.002417 mL/sec/cm3 0.000000 kbh 4 1 5
403 Liver extraction fraction 0.513548 0.000000 E 4 1 5
404 Hepatic plasma clearance 0.011308 mL/sec/cm3 0.000000 Ktrans 4 1 5
405 Hematocrit 0.418000 0.000000 H 4 2 5
406 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 5
407 Hepatocellular uptake rate 0.006419 mL/sec/cm3 0.000641 khe 4 2 5
408 Hepatocellular mean transit time 834.723557 sec 142.471249 Th 4 2 5
409 Biliary tissue excretion rate 0.001198 mL/sec/cm3 0.000000 Kbh 4 2 5
410 Hepatocellular tissue uptake rate 0.027908 mL/sec/cm3 0.000000 Khe 4 2 5
411 Biliary excretion rate 0.000922 mL/sec/cm3 0.000000 kbh 4 2 5
412 Liver extraction fraction 0.225716 0.000000 E 4 2 5
413 Hepatic plasma clearance 0.004970 mL/sec/cm3 0.000000 Ktrans 4 2 5
414 Hematocrit 0.418000 0.000000 H 4 1 6
415 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 6
416 Hepatocellular uptake rate 0.026134 mL/sec/cm3 0.001719 khe 4 1 6
417 Hepatocellular mean transit time 201.798523 sec 14.051229 Th 4 1 6
418 Biliary tissue excretion rate 0.004955 mL/sec/cm3 0.000000 Kbh 4 1 6
419 Hepatocellular tissue uptake rate 0.113624 mL/sec/cm3 0.000000 Khe 4 1 6
420 Biliary excretion rate 0.003816 mL/sec/cm3 0.000000 kbh 4 1 6
421 Liver extraction fraction 0.542725 0.000000 E 4 1 6
422 Hepatic plasma clearance 0.011950 mL/sec/cm3 0.000000 Ktrans 4 1 6
423 Hematocrit 0.418000 0.000000 H 4 2 6
424 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 6
425 Hepatocellular uptake rate 0.004853 mL/sec/cm3 0.000434 khe 4 2 6
426 Hepatocellular mean transit time 603.017578 sec 77.246780 Th 4 2 6
427 Biliary tissue excretion rate 0.001658 mL/sec/cm3 0.000000 Kbh 4 2 6
428 Hepatocellular tissue uptake rate 0.021100 mL/sec/cm3 0.000000 Khe 4 2 6
429 Biliary excretion rate 0.001277 mL/sec/cm3 0.000000 kbh 4 2 6
430 Liver extraction fraction 0.180600 0.000000 E 4 2 6
431 Hepatic plasma clearance 0.003977 mL/sec/cm3 0.000000 Ktrans 4 2 6
432 Hematocrit 0.418000 0.000000 H 4 1 7
433 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 7
434 Hepatocellular uptake rate 0.028803 mL/sec/cm3 0.001777 khe 4 1 7
435 Hepatocellular mean transit time 199.383467 sec 12.937531 Th 4 1 7
436 Biliary tissue excretion rate 0.005015 mL/sec/cm3 0.000000 Kbh 4 1 7
437 Hepatocellular tissue uptake rate 0.125230 mL/sec/cm3 0.000000 Khe 4 1 7
438 Biliary excretion rate 0.003862 mL/sec/cm3 0.000000 kbh 4 1 7
439 Liver extraction fraction 0.566742 0.000000 E 4 1 7
440 Hepatic plasma clearance 0.012479 mL/sec/cm3 0.000000 Ktrans 4 1 7
441 Hematocrit 0.418000 0.000000 H 4 2 7
442 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 7
443 Hepatocellular uptake rate 0.006605 mL/sec/cm3 0.000604 khe 4 2 7
444 Hepatocellular mean transit time 598.552559 sec 77.794632 Th 4 2 7
445 Biliary tissue excretion rate 0.001671 mL/sec/cm3 0.000000 Kbh 4 2 7
446 Hepatocellular tissue uptake rate 0.028719 mL/sec/cm3 0.000000 Khe 4 2 7
447 Biliary excretion rate 0.001286 mL/sec/cm3 0.000000 kbh 4 2 7
448 Liver extraction fraction 0.230758 0.000000 E 4 2 7
449 Hepatic plasma clearance 0.005081 mL/sec/cm3 0.000000 Ktrans 4 2 7
450 Hematocrit 0.418000 0.000000 H 4 1 8
451 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 1 8
452 Hepatocellular uptake rate 0.021571 mL/sec/cm3 0.001307 khe 4 1 8
453 Hepatocellular mean transit time 213.542713 sec 13.877482 Th 4 1 8
454 Biliary tissue excretion rate 0.004683 mL/sec/cm3 0.000000 Kbh 4 1 8
455 Hepatocellular tissue uptake rate 0.093788 mL/sec/cm3 0.000000 Khe 4 1 8
456 Biliary excretion rate 0.003606 mL/sec/cm3 0.000000 kbh 4 1 8
457 Liver extraction fraction 0.494865 0.000000 E 4 1 8
458 Hepatic plasma clearance 0.010896 mL/sec/cm3 0.000000 Ktrans 4 1 8
459 Hematocrit 0.418000 0.000000 H 4 2 8
460 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 4 2 8
461 Hepatocellular uptake rate 0.006650 mL/sec/cm3 0.000648 khe 4 2 8
462 Hepatocellular mean transit time 661.958695 sec 96.443350 Th 4 2 8
463 Biliary tissue excretion rate 0.001511 mL/sec/cm3 0.000000 Kbh 4 2 8
464 Hepatocellular tissue uptake rate 0.028915 mL/sec/cm3 0.000000 Khe 4 2 8
465 Biliary excretion rate 0.001163 mL/sec/cm3 0.000000 kbh 4 2 8
466 Liver extraction fraction 0.231968 0.000000 E 4 2 8
467 Hepatic plasma clearance 0.005108 mL/sec/cm3 0.000000 Ktrans 4 2 8
468 Hematocrit 0.418000 0.000000 H 5 1 1
469 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 1
470 Hepatocellular uptake rate 0.027413 mL/sec/cm3 0.001682 khe 5 1 1
471 Hepatocellular mean transit time 246.731319 sec 16.406922 Th 5 1 1
472 Biliary tissue excretion rate 0.004053 mL/sec/cm3 0.000000 Kbh 5 1 1
473 Hepatocellular tissue uptake rate 0.119189 mL/sec/cm3 0.000000 Khe 5 1 1
474 Biliary excretion rate 0.003121 mL/sec/cm3 0.000000 kbh 5 1 1
475 Liver extraction fraction 0.554563 0.000000 E 5 1 1
476 Hepatic plasma clearance 0.012211 mL/sec/cm3 0.000000 Ktrans 5 1 1
477 Hematocrit 0.418000 0.000000 H 5 1 2
478 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 2
479 Hepatocellular uptake rate 0.029190 mL/sec/cm3 0.000690 khe 5 1 2
480 Hepatocellular mean transit time 192.246433 sec 4.836834 Th 5 1 2
481 Biliary tissue excretion rate 0.005202 mL/sec/cm3 0.000000 Kbh 5 1 2
482 Hepatocellular tissue uptake rate 0.126911 mL/sec/cm3 0.000000 Khe 5 1 2
483 Biliary excretion rate 0.004005 mL/sec/cm3 0.000000 kbh 5 1 2
484 Liver extraction fraction 0.570014 0.000000 E 5 1 2
485 Hepatic plasma clearance 0.012551 mL/sec/cm3 0.000000 Ktrans 5 1 2
486 Hematocrit 0.418000 0.000000 H 5 1 3
487 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 3
488 Hepatocellular uptake rate 0.023123 mL/sec/cm3 0.002281 khe 5 1 3
489 Hepatocellular mean transit time 154.454455 sec 16.290498 Th 5 1 3
490 Biliary tissue excretion rate 0.006474 mL/sec/cm3 0.000000 Kbh 5 1 3
491 Hepatocellular tissue uptake rate 0.100536 mL/sec/cm3 0.000000 Khe 5 1 3
492 Biliary excretion rate 0.004985 mL/sec/cm3 0.000000 kbh 5 1 3
493 Liver extraction fraction 0.512232 0.000000 E 5 1 3
494 Hepatic plasma clearance 0.011279 mL/sec/cm3 0.000000 Ktrans 5 1 3
495 Hematocrit 0.418000 0.000000 H 5 1 4
496 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 4
497 Hepatocellular uptake rate 0.017874 mL/sec/cm3 0.000788 khe 5 1 4
498 Hepatocellular mean transit time 185.344175 sec 8.871480 Th 5 1 4
499 Biliary tissue excretion rate 0.005395 mL/sec/cm3 0.000000 Kbh 5 1 4
500 Hepatocellular tissue uptake rate 0.077715 mL/sec/cm3 0.000000 Khe 5 1 4
501 Biliary excretion rate 0.004154 mL/sec/cm3 0.000000 kbh 5 1 4
502 Liver extraction fraction 0.448054 0.000000 E 5 1 4
503 Hepatic plasma clearance 0.009866 mL/sec/cm3 0.000000 Ktrans 5 1 4
504 Hematocrit 0.418000 0.000000 H 5 1 5
505 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 5
506 Hepatocellular uptake rate 0.015750 mL/sec/cm3 0.001193 khe 5 1 5
507 Hepatocellular mean transit time 194.627433 sec 16.106847 Th 5 1 5
508 Biliary tissue excretion rate 0.005138 mL/sec/cm3 0.000000 Kbh 5 1 5
509 Hepatocellular tissue uptake rate 0.068477 mL/sec/cm3 0.000000 Khe 5 1 5
510 Biliary excretion rate 0.003956 mL/sec/cm3 0.000000 kbh 5 1 5
511 Liver extraction fraction 0.417006 0.000000 E 5 1 5
512 Hepatic plasma clearance 0.009182 mL/sec/cm3 0.000000 Ktrans 5 1 5
513 Hematocrit 0.418000 0.000000 H 5 1 6
514 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 5 1 6
515 Hepatocellular uptake rate 0.017684 mL/sec/cm3 0.001342 khe 5 1 6
516 Hepatocellular mean transit time 171.878130 sec 14.125022 Th 5 1 6
517 Biliary tissue excretion rate 0.005818 mL/sec/cm3 0.000000 Kbh 5 1 6
518 Hepatocellular tissue uptake rate 0.076888 mL/sec/cm3 0.000000 Khe 5 1 6
519 Biliary excretion rate 0.004480 mL/sec/cm3 0.000000 kbh 5 1 6
520 Liver extraction fraction 0.445411 0.000000 E 5 1 6
521 Hepatic plasma clearance 0.009808 mL/sec/cm3 0.000000 Ktrans 5 1 6
522 Hematocrit 0.418000 0.000000 H 6 1 1
523 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 1
524 Hepatocellular uptake rate 0.023093 mL/sec/cm3 0.001939 khe 6 1 1
525 Hepatocellular mean transit time 180.090839 sec 16.235359 Th 6 1 1
526 Biliary tissue excretion rate 0.005553 mL/sec/cm3 0.000000 Kbh 6 1 1
527 Hepatocellular tissue uptake rate 0.100406 mL/sec/cm3 0.000000 Khe 6 1 1
528 Biliary excretion rate 0.004276 mL/sec/cm3 0.000000 kbh 6 1 1
529 Liver extraction fraction 0.511909 0.000000 E 6 1 1
530 Hepatic plasma clearance 0.011272 mL/sec/cm3 0.000000 Ktrans 6 1 1
531 Hematocrit 0.418000 0.000000 H 6 1 2
532 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 2
533 Hepatocellular uptake rate 0.029692 mL/sec/cm3 0.001751 khe 6 1 2
534 Hepatocellular mean transit time 210.523275 sec 13.254362 Th 6 1 2
535 Biliary tissue excretion rate 0.004750 mL/sec/cm3 0.000000 Kbh 6 1 2
536 Hepatocellular tissue uptake rate 0.129094 mL/sec/cm3 0.000000 Khe 6 1 2
537 Biliary excretion rate 0.003658 mL/sec/cm3 0.000000 kbh 6 1 2
538 Liver extraction fraction 0.574188 0.000000 E 6 1 2
539 Hepatic plasma clearance 0.012643 mL/sec/cm3 0.000000 Ktrans 6 1 2
540 Hematocrit 0.418000 0.000000 H 6 1 3
541 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 3
542 Hepatocellular uptake rate 0.025392 mL/sec/cm3 0.002823 khe 6 1 3
543 Hepatocellular mean transit time 162.886138 sec 19.312284 Th 6 1 3
544 Biliary tissue excretion rate 0.006139 mL/sec/cm3 0.000000 Kbh 6 1 3
545 Hepatocellular tissue uptake rate 0.110399 mL/sec/cm3 0.000000 Khe 6 1 3
546 Biliary excretion rate 0.004727 mL/sec/cm3 0.000000 kbh 6 1 3
547 Liver extraction fraction 0.535569 0.000000 E 6 1 3
548 Hepatic plasma clearance 0.011793 mL/sec/cm3 0.000000 Ktrans 6 1 3
549 Hematocrit 0.418000 0.000000 H 6 1 4
550 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 4
551 Hepatocellular uptake rate 0.020645 mL/sec/cm3 0.001435 khe 6 1 4
552 Hepatocellular mean transit time 173.413608 sec 12.984491 Th 6 1 4
553 Biliary tissue excretion rate 0.005767 mL/sec/cm3 0.000000 Kbh 6 1 4
554 Hepatocellular tissue uptake rate 0.089759 mL/sec/cm3 0.000000 Khe 6 1 4
555 Biliary excretion rate 0.004440 mL/sec/cm3 0.000000 kbh 6 1 4
556 Liver extraction fraction 0.483893 0.000000 E 6 1 4
557 Hepatic plasma clearance 0.010655 mL/sec/cm3 0.000000 Ktrans 6 1 4
558 Hematocrit 0.418000 0.000000 H 6 1 5
559 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 5
560 Hepatocellular uptake rate 0.019787 mL/sec/cm3 0.001499 khe 6 1 5
561 Hepatocellular mean transit time 170.731411 sec 13.947304 Th 6 1 5
562 Biliary tissue excretion rate 0.005857 mL/sec/cm3 0.000000 Kbh 6 1 5
563 Hepatocellular tissue uptake rate 0.086031 mL/sec/cm3 0.000000 Khe 6 1 5
564 Biliary excretion rate 0.004510 mL/sec/cm3 0.000000 kbh 6 1 5
565 Liver extraction fraction 0.473306 0.000000 E 6 1 5
566 Hepatic plasma clearance 0.010422 mL/sec/cm3 0.000000 Ktrans 6 1 5
567 Hematocrit 0.418000 0.000000 H 6 1 6
568 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 6 1 6
569 Hepatocellular uptake rate 0.020815 mL/sec/cm3 0.001524 khe 6 1 6
570 Hepatocellular mean transit time 231.684464 sec 18.526224 Th 6 1 6
571 Biliary tissue excretion rate 0.004316 mL/sec/cm3 0.000000 Kbh 6 1 6
572 Hepatocellular tissue uptake rate 0.090499 mL/sec/cm3 0.000000 Khe 6 1 6
573 Biliary excretion rate 0.003323 mL/sec/cm3 0.000000 kbh 6 1 6
574 Liver extraction fraction 0.485944 0.000000 E 6 1 6
575 Hepatic plasma clearance 0.010700 mL/sec/cm3 0.000000 Ktrans 6 1 6
576 Hematocrit 0.418000 0.000000 H 7 1 1
577 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 1
578 Hepatocellular uptake rate 0.012259 mL/sec/cm3 0.000615 khe 7 1 1
579 Hepatocellular mean transit time 287.051267 sec 16.264662 Th 7 1 1
580 Biliary tissue excretion rate 0.003484 mL/sec/cm3 0.000000 Kbh 7 1 1
581 Hepatocellular tissue uptake rate 0.053298 mL/sec/cm3 0.000000 Khe 7 1 1
582 Biliary excretion rate 0.002682 mL/sec/cm3 0.000000 kbh 7 1 1
583 Liver extraction fraction 0.357627 0.000000 E 7 1 1
584 Hepatic plasma clearance 0.007875 mL/sec/cm3 0.000000 Ktrans 7 1 1
585 Hematocrit 0.418000 0.000000 H 7 1 2
586 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 2
587 Hepatocellular uptake rate 0.022070 mL/sec/cm3 0.002018 khe 7 1 2
588 Hepatocellular mean transit time 293.503375 sec 29.624750 Th 7 1 2
589 Biliary tissue excretion rate 0.003407 mL/sec/cm3 0.000000 Kbh 7 1 2
590 Hepatocellular tissue uptake rate 0.095958 mL/sec/cm3 0.000000 Khe 7 1 2
591 Biliary excretion rate 0.002623 mL/sec/cm3 0.000000 kbh 7 1 2
592 Liver extraction fraction 0.500582 0.000000 E 7 1 2
593 Hepatic plasma clearance 0.011022 mL/sec/cm3 0.000000 Ktrans 7 1 2
594 Hematocrit 0.418000 0.000000 H 7 1 3
595 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 3
596 Hepatocellular uptake rate 0.020564 mL/sec/cm3 0.002026 khe 7 1 3
597 Hepatocellular mean transit time 282.354635 sec 30.659355 Th 7 1 3
598 Biliary tissue excretion rate 0.003542 mL/sec/cm3 0.000000 Kbh 7 1 3
599 Hepatocellular tissue uptake rate 0.089409 mL/sec/cm3 0.000000 Khe 7 1 3
600 Biliary excretion rate 0.002727 mL/sec/cm3 0.000000 kbh 7 1 3
601 Liver extraction fraction 0.482917 0.000000 E 7 1 3
602 Hepatic plasma clearance 0.010633 mL/sec/cm3 0.000000 Ktrans 7 1 3
603 Hematocrit 0.418000 0.000000 H 7 1 4
604 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 4
605 Hepatocellular uptake rate 0.013127 mL/sec/cm3 0.000953 khe 7 1 4
606 Hepatocellular mean transit time 298.416370 sec 24.534799 Th 7 1 4
607 Biliary tissue excretion rate 0.003351 mL/sec/cm3 0.000000 Kbh 7 1 4
608 Hepatocellular tissue uptake rate 0.057074 mL/sec/cm3 0.000000 Khe 7 1 4
609 Biliary excretion rate 0.002580 mL/sec/cm3 0.000000 kbh 7 1 4
610 Liver extraction fraction 0.373498 0.000000 E 7 1 4
611 Hepatic plasma clearance 0.008224 mL/sec/cm3 0.000000 Ktrans 7 1 4
612 Hematocrit 0.418000 0.000000 H 7 1 5
613 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 5
614 Hepatocellular uptake rate 0.020795 mL/sec/cm3 0.002349 khe 7 1 5
615 Hepatocellular mean transit time 217.745080 sec 26.492837 Th 7 1 5
616 Biliary tissue excretion rate 0.004593 mL/sec/cm3 0.000000 Kbh 7 1 5
617 Hepatocellular tissue uptake rate 0.090411 mL/sec/cm3 0.000000 Khe 7 1 5
618 Biliary excretion rate 0.003536 mL/sec/cm3 0.000000 kbh 7 1 5
619 Liver extraction fraction 0.485700 0.000000 E 7 1 5
620 Hepatic plasma clearance 0.010695 mL/sec/cm3 0.000000 Ktrans 7 1 5
621 Hematocrit 0.418000 0.000000 H 7 1 6
622 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 7 1 6
623 Hepatocellular uptake rate 0.022667 mL/sec/cm3 0.002503 khe 7 1 6
624 Hepatocellular mean transit time 257.860271 sec 30.914503 Th 7 1 6
625 Biliary tissue excretion rate 0.003878 mL/sec/cm3 0.000000 Kbh 7 1 6
626 Hepatocellular tissue uptake rate 0.098553 mL/sec/cm3 0.000000 Khe 7 1 6
627 Biliary excretion rate 0.002986 mL/sec/cm3 0.000000 kbh 7 1 6
628 Liver extraction fraction 0.507254 0.000000 E 7 1 6
629 Hepatic plasma clearance 0.011169 mL/sec/cm3 0.000000 Ktrans 7 1 6
630 Hematocrit 0.418000 0.000000 H 8 1 1
631 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 1
632 Hepatocellular uptake rate 0.029344 mL/sec/cm3 0.001970 khe 8 1 1
633 Hepatocellular mean transit time 408.262045 sec 31.838820 Th 8 1 1
634 Biliary tissue excretion rate 0.002449 mL/sec/cm3 0.000000 Kbh 8 1 1
635 Hepatocellular tissue uptake rate 0.127585 mL/sec/cm3 0.000000 Khe 8 1 1
636 Biliary excretion rate 0.001886 mL/sec/cm3 0.000000 kbh 8 1 1
637 Liver extraction fraction 0.571310 0.000000 E 8 1 1
638 Hepatic plasma clearance 0.012580 mL/sec/cm3 0.000000 Ktrans 8 1 1
639 Hematocrit 0.418000 0.000000 H 8 1 2
640 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 2
641 Hepatocellular uptake rate 0.027849 mL/sec/cm3 0.002515 khe 8 1 2
642 Hepatocellular mean transit time 269.048876 sec 26.131604 Th 8 1 2
643 Biliary tissue excretion rate 0.003717 mL/sec/cm3 0.000000 Kbh 8 1 2
644 Hepatocellular tissue uptake rate 0.121082 mL/sec/cm3 0.000000 Khe 8 1 2
645 Biliary excretion rate 0.002862 mL/sec/cm3 0.000000 kbh 8 1 2
646 Liver extraction fraction 0.558453 0.000000 E 8 1 2
647 Hepatic plasma clearance 0.012297 mL/sec/cm3 0.000000 Ktrans 8 1 2
648 Hematocrit 0.418000 0.000000 H 8 1 3
649 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 3
650 Hepatocellular uptake rate 0.019728 mL/sec/cm3 0.001371 khe 8 1 3
651 Hepatocellular mean transit time 383.872404 sec 31.160715 Th 8 1 3
652 Biliary tissue excretion rate 0.002605 mL/sec/cm3 0.000000 Kbh 8 1 3
653 Hepatocellular tissue uptake rate 0.085774 mL/sec/cm3 0.000000 Khe 8 1 3
654 Biliary excretion rate 0.002006 mL/sec/cm3 0.000000 kbh 8 1 3
655 Liver extraction fraction 0.472562 0.000000 E 8 1 3
656 Hepatic plasma clearance 0.010405 mL/sec/cm3 0.000000 Ktrans 8 1 3
657 Hematocrit 0.418000 0.000000 H 8 1 4
658 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 4
659 Hepatocellular uptake rate 0.018832 mL/sec/cm3 0.001177 khe 8 1 4
660 Hepatocellular mean transit time 435.387822 sec 33.054295 Th 8 1 4
661 Biliary tissue excretion rate 0.002297 mL/sec/cm3 0.000000 Kbh 8 1 4
662 Hepatocellular tissue uptake rate 0.081878 mL/sec/cm3 0.000000 Khe 8 1 4
663 Biliary excretion rate 0.001769 mL/sec/cm3 0.000000 kbh 8 1 4
664 Liver extraction fraction 0.460991 0.000000 E 8 1 4
665 Hepatic plasma clearance 0.010151 mL/sec/cm3 0.000000 Ktrans 8 1 4
666 Hematocrit 0.418000 0.000000 H 8 1 5
667 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 5
668 Hepatocellular uptake rate 0.025961 mL/sec/cm3 0.002111 khe 8 1 5
669 Hepatocellular mean transit time 262.092578 sec 22.959490 Th 8 1 5
670 Biliary tissue excretion rate 0.003815 mL/sec/cm3 0.000000 Kbh 8 1 5
671 Hepatocellular tissue uptake rate 0.112874 mL/sec/cm3 0.000000 Khe 8 1 5
672 Biliary excretion rate 0.002938 mL/sec/cm3 0.000000 kbh 8 1 5
673 Liver extraction fraction 0.541079 0.000000 E 8 1 5
674 Hepatic plasma clearance 0.011914 mL/sec/cm3 0.000000 Ktrans 8 1 5
675 Hematocrit 0.418000 0.000000 H 8 1 6
676 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 8 1 6
677 Hepatocellular uptake rate 0.025441 mL/sec/cm3 0.002053 khe 8 1 6
678 Hepatocellular mean transit time 295.237391 sec 26.068654 Th 8 1 6
679 Biliary tissue excretion rate 0.003387 mL/sec/cm3 0.000000 Kbh 8 1 6
680 Hepatocellular tissue uptake rate 0.110613 mL/sec/cm3 0.000000 Khe 8 1 6
681 Biliary excretion rate 0.002608 mL/sec/cm3 0.000000 kbh 8 1 6
682 Liver extraction fraction 0.536050 0.000000 E 8 1 6
683 Hepatic plasma clearance 0.011803 mL/sec/cm3 0.000000 Ktrans 8 1 6
684 Hematocrit 0.418000 0.000000 H 9 1 1
685 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 9 1 1
686 Hepatocellular uptake rate 0.020030 mL/sec/cm3 0.000709 khe 9 1 1
687 Hepatocellular mean transit time 373.947283 sec 15.530816 Th 9 1 1
688 Biliary tissue excretion rate 0.002674 mL/sec/cm3 0.000000 Kbh 9 1 1
689 Hepatocellular tissue uptake rate 0.087087 mL/sec/cm3 0.000000 Khe 9 1 1
690 Biliary excretion rate 0.002059 mL/sec/cm3 0.000000 kbh 9 1 1
691 Liver extraction fraction 0.476350 0.000000 E 9 1 1
692 Hepatic plasma clearance 0.010489 mL/sec/cm3 0.000000 Ktrans 9 1 1
693 Hematocrit 0.418000 0.000000 H 9 1 2
694 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 9 1 2
695 Hepatocellular uptake rate 0.017119 mL/sec/cm3 0.001287 khe 9 1 2
696 Hepatocellular mean transit time 231.522778 sec 19.151147 Th 9 1 2
697 Biliary tissue excretion rate 0.004319 mL/sec/cm3 0.000000 Kbh 9 1 2
698 Hepatocellular tissue uptake rate 0.074433 mL/sec/cm3 0.000000 Khe 9 1 2
699 Biliary excretion rate 0.003326 mL/sec/cm3 0.000000 kbh 9 1 2
700 Liver extraction fraction 0.437408 0.000000 E 9 1 2
701 Hepatic plasma clearance 0.009631 mL/sec/cm3 0.000000 Ktrans 9 1 2
702 Hematocrit 0.418000 0.000000 H 9 1 3
703 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 9 1 3
704 Hepatocellular uptake rate 0.028307 mL/sec/cm3 0.002243 khe 9 1 3
705 Hepatocellular mean transit time 297.434220 sec 26.028315 Th 9 1 3
706 Biliary tissue excretion rate 0.003362 mL/sec/cm3 0.000000 Kbh 9 1 3
707 Hepatocellular tissue uptake rate 0.123073 mL/sec/cm3 0.000000 Khe 9 1 3
708 Biliary excretion rate 0.002589 mL/sec/cm3 0.000000 kbh 9 1 3
709 Liver extraction fraction 0.562470 0.000000 E 9 1 3
710 Hepatic plasma clearance 0.012385 mL/sec/cm3 0.000000 Ktrans 9 1 3
711 Hematocrit 0.418000 0.000000 H 9 1 4
712 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 9 1 4
713 Hepatocellular uptake rate 0.031829 mL/sec/cm3 0.002277 khe 9 1 4
714 Hepatocellular mean transit time 276.696420 sec 21.511310 Th 9 1 4
715 Biliary tissue excretion rate 0.003614 mL/sec/cm3 0.000000 Kbh 9 1 4
716 Hepatocellular tissue uptake rate 0.138388 mL/sec/cm3 0.000000 Khe 9 1 4
717 Biliary excretion rate 0.002783 mL/sec/cm3 0.000000 kbh 9 1 4
718 Liver extraction fraction 0.591092 0.000000 E 9 1 4
719 Hepatic plasma clearance 0.013015 mL/sec/cm3 0.000000 Ktrans 9 1 4
720 Hematocrit 0.418000 0.000000 H 10 1 1
721 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 1
722 Hepatocellular uptake rate 0.032653 mL/sec/cm3 0.002459 khe 10 1 1
723 Hepatocellular mean transit time 204.095965 sec 16.306195 Th 10 1 1
724 Biliary tissue excretion rate 0.004900 mL/sec/cm3 0.000000 Kbh 10 1 1
725 Hepatocellular tissue uptake rate 0.141969 mL/sec/cm3 0.000000 Khe 10 1 1
726 Biliary excretion rate 0.003773 mL/sec/cm3 0.000000 kbh 10 1 1
727 Liver extraction fraction 0.597252 0.000000 E 10 1 1
728 Hepatic plasma clearance 0.013151 mL/sec/cm3 0.000000 Ktrans 10 1 1
729 Hematocrit 0.418000 0.000000 H 10 1 2
730 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 2
731 Hepatocellular uptake rate 0.025971 mL/sec/cm3 0.001777 khe 10 1 2
732 Hepatocellular mean transit time 260.964310 sec 19.500936 Th 10 1 2
733 Biliary tissue excretion rate 0.003832 mL/sec/cm3 0.000000 Kbh 10 1 2
734 Hepatocellular tissue uptake rate 0.112917 mL/sec/cm3 0.000000 Khe 10 1 2
735 Biliary excretion rate 0.002951 mL/sec/cm3 0.000000 kbh 10 1 2
736 Liver extraction fraction 0.541175 0.000000 E 10 1 2
737 Hepatic plasma clearance 0.011916 mL/sec/cm3 0.000000 Ktrans 10 1 2
738 Hematocrit 0.418000 0.000000 H 10 1 3
739 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 3
740 Hepatocellular uptake rate 0.036772 mL/sec/cm3 0.002993 khe 10 1 3
741 Hepatocellular mean transit time 192.094645 sec 16.432004 Th 10 1 3
742 Biliary tissue excretion rate 0.005206 mL/sec/cm3 0.000000 Kbh 10 1 3
743 Hepatocellular tissue uptake rate 0.159880 mL/sec/cm3 0.000000 Khe 10 1 3
744 Biliary excretion rate 0.004008 mL/sec/cm3 0.000000 kbh 10 1 3
745 Liver extraction fraction 0.625472 0.000000 E 10 1 3
746 Hepatic plasma clearance 0.013772 mL/sec/cm3 0.000000 Ktrans 10 1 3
747 Hematocrit 0.418000 0.000000 H 10 1 4
748 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 4
749 Hepatocellular uptake rate 0.034563 mL/sec/cm3 0.003415 khe 10 1 4
750 Hepatocellular mean transit time 221.220680 sec 23.197005 Th 10 1 4
751 Biliary tissue excretion rate 0.004520 mL/sec/cm3 0.000000 Kbh 10 1 4
752 Hepatocellular tissue uptake rate 0.150275 mL/sec/cm3 0.000000 Khe 10 1 4
753 Biliary excretion rate 0.003481 mL/sec/cm3 0.000000 kbh 10 1 4
754 Liver extraction fraction 0.610850 0.000000 E 10 1 4
755 Hepatic plasma clearance 0.013450 mL/sec/cm3 0.000000 Ktrans 10 1 4
756 Hematocrit 0.418000 0.000000 H 10 1 5
757 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 5
758 Hepatocellular uptake rate 0.032724 mL/sec/cm3 0.002464 khe 10 1 5
759 Hepatocellular mean transit time 203.321189 sec 16.233566 Th 10 1 5
760 Biliary tissue excretion rate 0.004918 mL/sec/cm3 0.000000 Kbh 10 1 5
761 Hepatocellular tissue uptake rate 0.142280 mL/sec/cm3 0.000000 Khe 10 1 5
762 Biliary excretion rate 0.003787 mL/sec/cm3 0.000000 kbh 10 1 5
763 Liver extraction fraction 0.597778 0.000000 E 10 1 5
764 Hepatic plasma clearance 0.013162 mL/sec/cm3 0.000000 Ktrans 10 1 5
765 Hematocrit 0.418000 0.000000 H 10 1 6
766 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 10 1 6
767 Hepatocellular uptake rate 0.039966 mL/sec/cm3 0.002838 khe 10 1 6
768 Hepatocellular mean transit time 225.378400 sec 16.843082 Th 10 1 6
769 Biliary tissue excretion rate 0.004437 mL/sec/cm3 0.000000 Kbh 10 1 6
770 Hepatocellular tissue uptake rate 0.173767 mL/sec/cm3 0.000000 Khe 10 1 6
771 Biliary excretion rate 0.003416 mL/sec/cm3 0.000000 kbh 10 1 6
772 Liver extraction fraction 0.644771 0.000000 E 10 1 6
773 Hepatic plasma clearance 0.014197 mL/sec/cm3 0.000000 Ktrans 10 1 6
774 Hematocrit 0.418000 0.000000 H 11 1 1
775 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 1
776 Hepatocellular uptake rate 0.014012 mL/sec/cm3 0.000881 khe 11 1 1
777 Hepatocellular mean transit time 227.051874 sec 15.786653 Th 11 1 1
778 Biliary tissue excretion rate 0.004404 mL/sec/cm3 0.000000 Kbh 11 1 1
779 Hepatocellular tissue uptake rate 0.060920 mL/sec/cm3 0.000000 Khe 11 1 1
780 Biliary excretion rate 0.003391 mL/sec/cm3 0.000000 kbh 11 1 1
781 Liver extraction fraction 0.388880 0.000000 E 11 1 1
782 Hepatic plasma clearance 0.008563 mL/sec/cm3 0.000000 Ktrans 11 1 1
783 Hematocrit 0.418000 0.000000 H 11 1 2
784 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 2
785 Hepatocellular uptake rate 0.028364 mL/sec/cm3 0.001967 khe 11 1 2
786 Hepatocellular mean transit time 269.369316 sec 20.372041 Th 11 1 2
787 Biliary tissue excretion rate 0.003712 mL/sec/cm3 0.000000 Kbh 11 1 2
788 Hepatocellular tissue uptake rate 0.123322 mL/sec/cm3 0.000000 Khe 11 1 2
789 Biliary excretion rate 0.002859 mL/sec/cm3 0.000000 kbh 11 1 2
790 Liver extraction fraction 0.562969 0.000000 E 11 1 2
791 Hepatic plasma clearance 0.012396 mL/sec/cm3 0.000000 Ktrans 11 1 2
792 Hematocrit 0.418000 0.000000 H 11 1 3
793 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 3
794 Hepatocellular uptake rate 0.030036 mL/sec/cm3 0.002657 khe 11 1 3
795 Hepatocellular mean transit time 219.517315 sec 20.772082 Th 11 1 3
796 Biliary tissue excretion rate 0.004555 mL/sec/cm3 0.000000 Kbh 11 1 3
797 Hepatocellular tissue uptake rate 0.130592 mL/sec/cm3 0.000000 Khe 11 1 3
798 Biliary excretion rate 0.003508 mL/sec/cm3 0.000000 kbh 11 1 3
799 Liver extraction fraction 0.577006 0.000000 E 11 1 3
800 Hepatic plasma clearance 0.012705 mL/sec/cm3 0.000000 Ktrans 11 1 3
801 Hematocrit 0.418000 0.000000 H 11 1 4
802 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 4
803 Hepatocellular uptake rate 0.029084 mL/sec/cm3 0.002288 khe 11 1 4
804 Hepatocellular mean transit time 234.766701 sec 19.873939 Th 11 1 4
805 Biliary tissue excretion rate 0.004260 mL/sec/cm3 0.000000 Kbh 11 1 4
806 Hepatocellular tissue uptake rate 0.126451 mL/sec/cm3 0.000000 Khe 11 1 4
807 Biliary excretion rate 0.003280 mL/sec/cm3 0.000000 kbh 11 1 4
808 Liver extraction fraction 0.569124 0.000000 E 11 1 4
809 Hepatic plasma clearance 0.012532 mL/sec/cm3 0.000000 Ktrans 11 1 4
810 Hematocrit 0.418000 0.000000 H 11 1 5
811 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 5
812 Hepatocellular uptake rate 0.023826 mL/sec/cm3 0.001681 khe 11 1 5
813 Hepatocellular mean transit time 313.385810 sec 24.843092 Th 11 1 5
814 Biliary tissue excretion rate 0.003191 mL/sec/cm3 0.000000 Kbh 11 1 5
815 Hepatocellular tissue uptake rate 0.103590 mL/sec/cm3 0.000000 Khe 11 1 5
816 Biliary excretion rate 0.002457 mL/sec/cm3 0.000000 kbh 11 1 5
817 Liver extraction fraction 0.519703 0.000000 E 11 1 5
818 Hepatic plasma clearance 0.011443 mL/sec/cm3 0.000000 Ktrans 11 1 5
819 Hematocrit 0.418000 0.000000 H 11 1 6
820 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 11 1 6
821 Hepatocellular uptake rate 0.029338 mL/sec/cm3 0.002007 khe 11 1 6
822 Hepatocellular mean transit time 264.579427 sec 19.666217 Th 11 1 6
823 Biliary tissue excretion rate 0.003780 mL/sec/cm3 0.000000 Kbh 11 1 6
824 Hepatocellular tissue uptake rate 0.127557 mL/sec/cm3 0.000000 Khe 11 1 6
825 Biliary excretion rate 0.002910 mL/sec/cm3 0.000000 kbh 11 1 6
826 Liver extraction fraction 0.571256 0.000000 E 11 1 6
827 Hepatic plasma clearance 0.012578 mL/sec/cm3 0.000000 Ktrans 11 1 6
828 Hematocrit 0.418000 0.000000 H 12 1 1
829 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 12 1 1
830 Hepatocellular uptake rate 0.030000 mL/sec/cm3 0.001981 khe 12 1 1
831 Hepatocellular mean transit time 326.139621 sec 23.676019 Th 12 1 1
832 Biliary tissue excretion rate 0.003066 mL/sec/cm3 0.000000 Kbh 12 1 1
833 Hepatocellular tissue uptake rate 0.130435 mL/sec/cm3 0.000000 Khe 12 1 1
834 Biliary excretion rate 0.002361 mL/sec/cm3 0.000000 kbh 12 1 1
835 Liver extraction fraction 0.576713 0.000000 E 12 1 1
836 Hepatic plasma clearance 0.012699 mL/sec/cm3 0.000000 Ktrans 12 1 1
837 Hematocrit 0.418000 0.000000 H 12 1 2
838 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 12 1 2
839 Hepatocellular uptake rate 0.027448 mL/sec/cm3 0.001948 khe 12 1 2
840 Hepatocellular mean transit time 262.269019 sec 19.984344 Th 12 1 2
841 Biliary tissue excretion rate 0.003813 mL/sec/cm3 0.000000 Kbh 12 1 2
842 Hepatocellular tissue uptake rate 0.119340 mL/sec/cm3 0.000000 Khe 12 1 2
843 Biliary excretion rate 0.002936 mL/sec/cm3 0.000000 kbh 12 1 2
844 Liver extraction fraction 0.554877 0.000000 E 12 1 2
845 Hepatic plasma clearance 0.012218 mL/sec/cm3 0.000000 Ktrans 12 1 2
846 Hematocrit 0.418000 0.000000 H 12 1 3
847 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 12 1 3
848 Hepatocellular uptake rate 0.030764 mL/sec/cm3 0.002113 khe 12 1 3
849 Hepatocellular mean transit time 261.478684 sec 19.132158 Th 12 1 3
850 Biliary tissue excretion rate 0.003824 mL/sec/cm3 0.000000 Kbh 12 1 3
851 Hepatocellular tissue uptake rate 0.133755 mL/sec/cm3 0.000000 Khe 12 1 3
852 Biliary excretion rate 0.002945 mL/sec/cm3 0.000000 kbh 12 1 3
853 Liver extraction fraction 0.582837 0.000000 E 12 1 3
854 Hepatic plasma clearance 0.012833 mL/sec/cm3 0.000000 Ktrans 12 1 3
855 Hematocrit 0.418000 0.000000 H 12 1 4
856 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 12 1 4
857 Hepatocellular uptake rate 0.028471 mL/sec/cm3 0.001859 khe 12 1 4
858 Hepatocellular mean transit time 269.447999 sec 18.903053 Th 12 1 4
859 Biliary tissue excretion rate 0.003711 mL/sec/cm3 0.000000 Kbh 12 1 4
860 Hepatocellular tissue uptake rate 0.123788 mL/sec/cm3 0.000000 Khe 12 1 4
861 Biliary excretion rate 0.002858 mL/sec/cm3 0.000000 kbh 12 1 4
862 Liver extraction fraction 0.563896 0.000000 E 12 1 4
863 Hepatic plasma clearance 0.012416 mL/sec/cm3 0.000000 Ktrans 12 1 4
864 Hematocrit 0.418000 0.000000 H 13 1 1
865 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 1
866 Hepatocellular uptake rate 0.019085 mL/sec/cm3 0.002455 khe 13 1 1
867 Hepatocellular mean transit time 156.031562 sec 21.402089 Th 13 1 1
868 Biliary tissue excretion rate 0.006409 mL/sec/cm3 0.000000 Kbh 13 1 1
869 Hepatocellular tissue uptake rate 0.082977 mL/sec/cm3 0.000000 Khe 13 1 1
870 Biliary excretion rate 0.004935 mL/sec/cm3 0.000000 kbh 13 1 1
871 Liver extraction fraction 0.464307 0.000000 E 13 1 1
872 Hepatic plasma clearance 0.010224 mL/sec/cm3 0.000000 Ktrans 13 1 1
873 Hematocrit 0.418000 0.000000 H 13 2 1
874 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 1
875 Hepatocellular uptake rate 0.024808 mL/sec/cm3 0.001606 khe 13 2 1
876 Hepatocellular mean transit time 244.656111 sec 17.235264 Th 13 2 1
877 Biliary tissue excretion rate 0.004087 mL/sec/cm3 0.000000 Kbh 13 2 1
878 Hepatocellular tissue uptake rate 0.107860 mL/sec/cm3 0.000000 Khe 13 2 1
879 Biliary excretion rate 0.003147 mL/sec/cm3 0.000000 kbh 13 2 1
880 Liver extraction fraction 0.529778 0.000000 E 13 2 1
881 Hepatic plasma clearance 0.011665 mL/sec/cm3 0.000000 Ktrans 13 2 1
882 Hematocrit 0.418000 0.000000 H 13 1 2
883 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 2
884 Hepatocellular uptake rate 0.026554 mL/sec/cm3 0.002467 khe 13 1 2
885 Hepatocellular mean transit time 187.581317 sec 18.382557 Th 13 1 2
886 Biliary tissue excretion rate 0.005331 mL/sec/cm3 0.000000 Kbh 13 1 2
887 Hepatocellular tissue uptake rate 0.115452 mL/sec/cm3 0.000000 Khe 13 1 2
888 Biliary excretion rate 0.004105 mL/sec/cm3 0.000000 kbh 13 1 2
889 Liver extraction fraction 0.546681 0.000000 E 13 1 2
890 Hepatic plasma clearance 0.012037 mL/sec/cm3 0.000000 Ktrans 13 1 2
891 Hematocrit 0.418000 0.000000 H 13 2 2
892 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 2
893 Hepatocellular uptake rate 0.027595 mL/sec/cm3 0.001957 khe 13 2 2
894 Hepatocellular mean transit time 237.503247 sec 18.192700 Th 13 2 2
895 Biliary tissue excretion rate 0.004210 mL/sec/cm3 0.000000 Kbh 13 2 2
896 Hepatocellular tissue uptake rate 0.119980 mL/sec/cm3 0.000000 Khe 13 2 2
897 Biliary excretion rate 0.003242 mL/sec/cm3 0.000000 kbh 13 2 2
898 Liver extraction fraction 0.556197 0.000000 E 13 2 2
899 Hepatic plasma clearance 0.012247 mL/sec/cm3 0.000000 Ktrans 13 2 2
900 Hematocrit 0.418000 0.000000 H 13 1 3
901 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 3
902 Hepatocellular uptake rate 0.024377 mL/sec/cm3 0.002563 khe 13 1 3
903 Hepatocellular mean transit time 214.667832 sec 24.050896 Th 13 1 3
904 Biliary tissue excretion rate 0.004658 mL/sec/cm3 0.000000 Kbh 13 1 3
905 Hepatocellular tissue uptake rate 0.105988 mL/sec/cm3 0.000000 Khe 13 1 3
906 Biliary excretion rate 0.003587 mL/sec/cm3 0.000000 kbh 13 1 3
907 Liver extraction fraction 0.525415 0.000000 E 13 1 3
908 Hepatic plasma clearance 0.011569 mL/sec/cm3 0.000000 Ktrans 13 1 3
909 Hematocrit 0.418000 0.000000 H 13 2 3
910 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 3
911 Hepatocellular uptake rate 0.022180 mL/sec/cm3 0.001826 khe 13 2 3
912 Hepatocellular mean transit time 226.709014 sec 20.299682 Th 13 2 3
913 Biliary tissue excretion rate 0.004411 mL/sec/cm3 0.000000 Kbh 13 2 3
914 Hepatocellular tissue uptake rate 0.096435 mL/sec/cm3 0.000000 Khe 13 2 3
915 Biliary excretion rate 0.003396 mL/sec/cm3 0.000000 kbh 13 2 3
916 Liver extraction fraction 0.501822 0.000000 E 13 2 3
917 Hepatic plasma clearance 0.011050 mL/sec/cm3 0.000000 Ktrans 13 2 3
918 Hematocrit 0.418000 0.000000 H 13 1 4
919 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 4
920 Hepatocellular uptake rate 0.037584 mL/sec/cm3 0.002927 khe 13 1 4
921 Hepatocellular mean transit time 254.315529 sec 21.112256 Th 13 1 4
922 Biliary tissue excretion rate 0.003932 mL/sec/cm3 0.000000 Kbh 13 1 4
923 Hepatocellular tissue uptake rate 0.163407 mL/sec/cm3 0.000000 Khe 13 1 4
924 Biliary excretion rate 0.003028 mL/sec/cm3 0.000000 kbh 13 1 4
925 Liver extraction fraction 0.630570 0.000000 E 13 1 4
926 Hepatic plasma clearance 0.013885 mL/sec/cm3 0.000000 Ktrans 13 1 4
927 Hematocrit 0.418000 0.000000 H 13 2 4
928 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 4
929 Hepatocellular uptake rate 0.032488 mL/sec/cm3 0.003095 khe 13 2 4
930 Hepatocellular mean transit time 241.158572 sec 24.217476 Th 13 2 4
931 Biliary tissue excretion rate 0.004147 mL/sec/cm3 0.000000 Kbh 13 2 4
932 Hepatocellular tissue uptake rate 0.141253 mL/sec/cm3 0.000000 Khe 13 2 4
933 Biliary excretion rate 0.003193 mL/sec/cm3 0.000000 kbh 13 2 4
934 Liver extraction fraction 0.596035 0.000000 E 13 2 4
935 Hepatic plasma clearance 0.013124 mL/sec/cm3 0.000000 Ktrans 13 2 4
936 Hematocrit 0.418000 0.000000 H 13 1 5
937 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 5
938 Hepatocellular uptake rate 0.039824 mL/sec/cm3 0.004918 khe 13 1 5
939 Hepatocellular mean transit time 189.275595 sec 24.429376 Th 13 1 5
940 Biliary tissue excretion rate 0.005283 mL/sec/cm3 0.000000 Kbh 13 1 5
941 Hepatocellular tissue uptake rate 0.173150 mL/sec/cm3 0.000000 Khe 13 1 5
942 Biliary excretion rate 0.004068 mL/sec/cm3 0.000000 kbh 13 1 5
943 Liver extraction fraction 0.643956 0.000000 E 13 1 5
944 Hepatic plasma clearance 0.014179 mL/sec/cm3 0.000000 Ktrans 13 1 5
945 Hematocrit 0.418000 0.000000 H 13 2 5
946 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 5
947 Hepatocellular uptake rate 0.028822 mL/sec/cm3 0.002995 khe 13 2 5
948 Hepatocellular mean transit time 180.559714 sec 19.678171 Th 13 2 5
949 Biliary tissue excretion rate 0.005538 mL/sec/cm3 0.000000 Kbh 13 2 5
950 Hepatocellular tissue uptake rate 0.125312 mL/sec/cm3 0.000000 Khe 13 2 5
951 Biliary excretion rate 0.004265 mL/sec/cm3 0.000000 kbh 13 2 5
952 Liver extraction fraction 0.566902 0.000000 E 13 2 5
953 Hepatic plasma clearance 0.012483 mL/sec/cm3 0.000000 Ktrans 13 2 5
954 Hematocrit 0.418000 0.000000 H 13 1 6
955 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 1 6
956 Hepatocellular uptake rate 0.037123 mL/sec/cm3 0.003325 khe 13 1 6
957 Hepatocellular mean transit time 204.034295 sec 19.236146 Th 13 1 6
958 Biliary tissue excretion rate 0.004901 mL/sec/cm3 0.000000 Kbh 13 1 6
959 Hepatocellular tissue uptake rate 0.161406 mL/sec/cm3 0.000000 Khe 13 1 6
960 Biliary excretion rate 0.003774 mL/sec/cm3 0.000000 kbh 13 1 6
961 Liver extraction fraction 0.627695 0.000000 E 13 1 6
962 Hepatic plasma clearance 0.013821 mL/sec/cm3 0.000000 Ktrans 13 1 6
963 Hematocrit 0.418000 0.000000 H 13 2 6
964 Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 ve 13 2 6
965 Hepatocellular uptake rate 0.027368 mL/sec/cm3 0.001377 khe 13 2 6
966 Hepatocellular mean transit time 212.489355 sec 11.312341 Th 13 2 6
967 Biliary tissue excretion rate 0.004706 mL/sec/cm3 0.000000 Kbh 13 2 6
968 Hepatocellular tissue uptake rate 0.118990 mL/sec/cm3 0.000000 Khe 13 2 6
969 Biliary excretion rate 0.003624 mL/sec/cm3 0.000000 kbh 13 2 6
970 Liver extraction fraction 0.554151 0.000000 E 13 2 6
971 Hepatic plasma clearance 0.012202 mL/sec/cm3 0.000000 Ktrans 13 2 6
Plot individual results#
Now let’s calculate the average biomarker values per substudy for saline data only. For this exercise, let’s specify khe and kbh as the biomarker parameters that we are interested in. For each biomarker, we can plot the avergae biomarker values along with their 95% confidence intervals for each study group. We can also calculate an average ‘benchmark’ value across all study groups for each biomarker, and overlay these on the graphs to see whether the observed values lie within these ranges. red lines indicate the average benchmark value, while blue represents the upper and lower limits of the 95% confidence intervals (CIs) associated with these benchmarks.
# Customise plot settings
plt.rcParams['savefig.dpi'] = 300
plt.rcParams["axes.labelsize"] = 50
plt.rcParams["axes.titlesize"] = 50
plt.rcParams["axes.labelweight"] = 'bold'
plt.rcParams["axes.titleweight"] = 'bold'
plt.rcParams["font.weight"] = 'bold'
plt.rc('axes', linewidth=2)
plt.rc('xtick', labelsize=40)
plt.rc('ytick', labelsize=40)
plt.rcParams["lines.linewidth"] = 4
plt.rcParams['lines.markersize'] = 12
# Create list of biomarkers (parameters) of interest
params = ['khe', 'kbh']
# Extract data of interest, i.e., visit 1 data for parameters of interest
visitOneData = results.query('parameter in @params and visit==1')
# Get statistical summaries per parameter and study group
stat_summary = (visitOneData
.groupby(['parameter', 'study'])['value']
.agg(['mean']))
# Calculate benchmark values per parameter by averaging all study group averages
benchmarks = (stat_summary
.groupby(['parameter'])['mean']
.agg(['mean', 'sem']))
# Calculate the 95% confidence intervals for each parameter benchmark
benchmarks['CI95'] = (benchmarks['sem'].mul(1.96))
# Sort dataframes
visitOneData_sorted = visitOneData.sort_values(['parameter'], ascending=[False])
benchmarks_sorted = benchmarks.sort_values(['parameter'], ascending=[False])
# Plot distributions across all study groups per biomarker of interest
g = sns.catplot(data=visitOneData_sorted,
x='study',
y='value',
col='parameter',
kind='point',
capsize=0.2,
sharey=False,
linestyle='none',
height=14,
aspect=1.2,
color='k',
errorbar=('ci', 95))
g.set_titles("") # set custom subplot titles
# Set limits for y-axes
g.axes[0, 0].set(ylim=([0, 0.05]))
g.axes[0, 1].set(ylim=([0, 0.006]))
ylabels = ['$k_{he}$', '$k_{bh}$'] # define labels for y-axis
# Assign values from benchmarks dataframe to be
# used as horizontal lines to overlay on plots
means = benchmarks_sorted['mean']
lower_cis = means - benchmarks_sorted['CI95']
upper_cis = means + benchmarks_sorted['CI95']
# iterate through subplots to overlay y-labels and axis lines
for i in range(len(ylabels)):
g.axes[0, i].set_ylabel(f"{ylabels[i]} [mL/sec/cm3]")
g.axes[0, i].axhline(means.iloc[i], color='blue', ls=':')
g.axes[0, i].axhline(lower_cis.iloc[i], color='red', ls='--')
g.axes[0, i].axhline(upper_cis.iloc[i], color='red', ls='--')
plt.tight_layout()
plt.show()
# Choose the last image as a thumbnail for the gallery
# sphinx_gallery_thumbnail_number = -1
Total running time of the script: (0 minutes 56.176 seconds)