Liver function: drug effects

A series of preclinical and clinical experiments performed to demonstrate that gadoxetate uptake and excretion rates in liver are biomarkers for drug-induced inhibition of liver function.

Clinical - rifampicin induced inhibition (short protocol)

Clinical - rifampicin induced inhibition (short protocol)

Preclinical - repeat dosing effects on liver function

Preclinical - repeat dosing effects on liver function

Clinical - rifampicin effect in subjects with impaired liver function

Clinical - rifampicin effect in subjects with impaired liver function

Clinical - rifampicin induced inhibition of liver function

Clinical - rifampicin induced inhibition of liver function

Preclinical - reproducibility of hepatocellular function

Preclinical - reproducibility of hepatocellular function

Preclinical - effect on liver function of 6 test drugs

Preclinical - effect on liver function of 6 test drugs