.. _sphx_glr_generated_examples_liver:

.. _liver-applications-ddi:

****************************
Liver function: drug effects
****************************

A series of preclinical and clinical experiments performed to demonstrate that 
gadoxetate uptake and excretion rates in liver are biomarkers for drug-induced 
inhibition of liver function.




.. raw:: html

    <div class="sphx-glr-thumbnails">

.. thumbnail-parent-div-open

.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="This example illustrates the use of AortaLiver for joint fitting of  aorta and liver signals to a whole-body model. The use case is provided by the  liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. The data and analysis was first  presented at the ISMRM in 2024 (Min et al 2024, manuscript in press). ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan_volunteers_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan_volunteers.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Clinical - rifampicin induced inhibition (short protocol)</div>
    </div>


.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="This example illustrates the use of Liver for fitting of signals  measured in liver. The use case is provided by the liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. The manuscript relating to this data and analysis is currently in preparation. ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan_mdosing_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan_mdosing.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Preclinical - repeat dosing effects on liver function</div>
    </div>


.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="The data show in this example aimed to demonstrates the effect of rifampicin  on liver function of patients with impaired function. The use  case is provided by the liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan_patients_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan_patients.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Clinical - rifampicin effect in subjects with impaired liver function</div>
    </div>


.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="This example illustrates the use of AortaLiver2scan for joint  fitting of aorta and liver signals measured over 2 separate scans. The use  case is provided by the liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. The data and analysis was first  presented at the ISMRM in 2024 (Min et al 2024, manuscript in press). ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan_volunteers_2scan_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan_volunteers_2scan.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Clinical - rifampicin induced inhibition of liver function</div>
    </div>


.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="This example illustrates the use of Liver for fitting of signals  measured in liver. The use case is provided by the liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. The data and analysis were first  published in Gunwhy et al. (2024). ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan_repro_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan_repro.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Preclinical - reproducibility of hepatocellular function</div>
    </div>


.. raw:: html

    <div class="sphx-glr-thumbcontainer" tooltip="This example illustrates the use of Liver for fitting of signals  measured in liver. The use case is provided by the liver work package of the  TRISTAN project  which develops imaging  biomarkers for drug safety assessment. The data and analysis were first  published in Melillo et al (2023). ">

.. only:: html

  .. image:: /generated/examples/liver/images/thumb/sphx_glr_plot_tristan6drugs_thumb.png
    :alt:

  :ref:`sphx_glr_generated_examples_liver_plot_tristan6drugs.py`

.. raw:: html

      <div class="sphx-glr-thumbnail-title">Preclinical - effect on liver function of 6 test drugs</div>
    </div>


.. thumbnail-parent-div-close

.. raw:: html

    </div>


.. toctree::
   :hidden:

   /generated/examples/liver/plot_tristan_volunteers
   /generated/examples/liver/plot_tristan_mdosing
   /generated/examples/liver/plot_tristan_patients
   /generated/examples/liver/plot_tristan_volunteers_2scan
   /generated/examples/liver/plot_tristan_repro
   /generated/examples/liver/plot_tristan6drugs