Note
Go to the end to download the full example code.
Preclinical - reproducibility of hepatocellular function#
This example illustrates the use of Liver for fitting of signals
measured in liver. The use case is provided by the liver work package of the
TRISTAN project which develops imaging
biomarkers for drug safety assessment. The data and analysis were first
published in Gunwhy et al. (2024).
The specific objective of the study was to to identify the main sources of variability in DCE-MRI biomarkers of hepatocellular function in rats. This was done by comparing data measured at different centres and field strengths, at different days in the same subjects, and over the course of several months in the same centre.
The study presented here measured gadoxetate uptake and excretion in healthy rats either scanned once with vehicle or twice with either vehicle or 10 mg/kg of rifampicin at follow-up. Studies were performed in preclinical MRI scanners at 3 different centers and 2 different field strengths. Results demonstrated significant differences between substudies for uptake and excretion. Within-subject differences were substantially smaller for excretion but less so for uptake. Rifampicin-induced inhibition was safely above the detection limits for both uptake and excretion. Most of the variability in individual data was accounted for by between-subject and between-centre variability, substantially more than the between-day variation. Significant differences in excretion were observed between field strengths at the same centre, between centres at the same field strength, and between repeat experiments over 2 months apart in the same centre.
Reference
Gunwhy ER, Hines CDG, Green C, Laitinen I, Tadimalla S, Hockings PD, Schütz G, Kenna JG, Sourbron S, Waterton JC. Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study. MAGMA. 2024 Aug;37(4):697-708. [DOI]
Setup#
Model definition#
In order to avoid some repetition in this script, we define a function that returns a trained model for a single dataset.
The model uses a standardized, population-average input function and fits for only 2 parameters, fixing all other free parameters to typical values for this rat model:
def tristan_rat(roi, par, **kwargs):
# High-resolution time points for prediction
t = np.arange(0, np.amax(roi['time'])+0.5, 0.5)
# Standard input function
ca = dc.aif_tristan_rat(t, BAT=par['BAT'], duration=par['duration'])
# Liver model with population input function
model = dc.Liver(
# Input parameters
t = t,
ca = ca,
# Acquisition parameters
field_strength = par['field_strength'],
TR = par['TR'],
FA = par['FA'],
n0 = par['n0'],
# Configure as in the TRISTAN-rat study
config = 'TRISTAN-rat',
)
return model.train(roi['time'], roi['liver'], **kwargs)
Check model fit#
Before running the full analysis on all cases, lets illustrate the results by fitting the baseline visit for the first subject. We use maximum verbosity to get some feedback about the iterations:
Iteration Total nfev Cost Cost reduction Step norm Optimality
0 1 1.1566e+02 2.83e+04
1 3 5.9371e+01 5.63e+01 4.50e+02 4.55e+03
2 5 4.9338e+01 1.00e+01 3.37e+02 2.29e+03
3 6 3.7455e+01 1.19e+01 5.84e+02 7.47e+03
4 7 1.8533e+01 1.89e+01 3.67e+01 7.67e+02
5 8 1.5677e+01 2.86e+00 1.26e+02 1.58e+03
6 9 1.3881e+01 1.80e+00 2.61e+00 3.34e+01
7 10 1.3881e+01 8.55e-04 1.56e-02 3.45e-02
`xtol` termination condition is satisfied.
Function evaluations 10, initial cost 1.1566e+02, final cost 1.3881e+01, first-order optimality 3.45e-02.
Plot the results to check that the model has fitted the data:
Print the measured model parameters and any derived parameters and check that standard deviations of measured parameters are small relative to the value, indicating that the parameters are measured reliably:
model.print_params(round_to=3)
--------------------------------
Free parameters with their stdev
--------------------------------
Hepatocellular uptake rate (khe): 0.023 (0.003) mL/sec/cm3
Hepatocellular mean transit time (Th): 263.43 (33.158) sec
----------------------------
Fixed and derived parameters
----------------------------
Hematocrit (H): 0.418
Liver extracellular volume fraction (ve): 0.23 mL/cm3
Biliary tissue excretion rate (Kbh): 0.004 mL/sec/cm3
Hepatocellular tissue uptake rate (Khe): 0.101 mL/sec/cm3
Biliary excretion rate (kbh): 0.003 mL/sec/cm3
Liver extraction fraction (E): 0.513
Hepatic plasma clearance (Ktrans): 0.011 mL/sec/cm3
Fit all data#
Now that we have illustrated an individual result in some detail, we proceed with fitting all the data. Results are stored in a dataframe in long format:
results = []
# Loop over all datasets
for subj in rois.keys():
for visit in rois[subj].keys():
roi = rois[subj][visit]
par = pars[subj][visit]
# Generate a trained model
model = tristan_rat(roi, par, xtol=1e-3)
# Export fitted parameters as lists
rows = model.export_params(type='list')
# Add study, visit and subject info
rows = [row + [par['study'], par['visit'], subj] for row in rows]
# Add to the list of all results
results += rows
# Combine all results into a single dataframe.
cols = ['parameter', 'name', 'value', 'unit', 'stdev', 'study',
'visit', 'subject']
results = pd.DataFrame(results, columns=cols)
# Print all results
print(results.to_string())
parameter name value unit stdev study visit subject
0 H Hematocrit 0.418000 0.000000 1 1 S01-01
1 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-01
2 khe Hepatocellular uptake rate 0.023169 mL/sec/cm3 0.002680 1 1 S01-01
3 Th Hepatocellular mean transit time 263.430181 sec 33.157686 1 1 S01-01
4 Kbh Biliary tissue excretion rate 0.003796 mL/sec/cm3 0.000000 1 1 S01-01
5 Khe Hepatocellular tissue uptake rate 0.100733 mL/sec/cm3 0.000000 1 1 S01-01
6 kbh Biliary excretion rate 0.002923 mL/sec/cm3 0.000000 1 1 S01-01
7 E Liver extraction fraction 0.512720 0.000000 1 1 S01-01
8 Ktrans Hepatic plasma clearance 0.011290 mL/sec/cm3 0.000000 1 1 S01-01
9 H Hematocrit 0.418000 0.000000 1 2 S01-01
10 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-01
11 khe Hepatocellular uptake rate 0.021450 mL/sec/cm3 0.003795 1 2 S01-01
12 Th Hepatocellular mean transit time 239.891180 sec 45.997190 1 2 S01-01
13 Kbh Biliary tissue excretion rate 0.004169 mL/sec/cm3 0.000000 1 2 S01-01
14 Khe Hepatocellular tissue uptake rate 0.093262 mL/sec/cm3 0.000000 1 2 S01-01
15 kbh Biliary excretion rate 0.003210 mL/sec/cm3 0.000000 1 2 S01-01
16 E Liver extraction fraction 0.493458 0.000000 1 2 S01-01
17 Ktrans Hepatic plasma clearance 0.010865 mL/sec/cm3 0.000000 1 2 S01-01
18 H Hematocrit 0.418000 0.000000 1 1 S01-02
19 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-02
20 khe Hepatocellular uptake rate 0.023849 mL/sec/cm3 0.002364 1 1 S01-02
21 Th Hepatocellular mean transit time 256.805196 sec 27.585677 1 1 S01-02
22 Kbh Biliary tissue excretion rate 0.003894 mL/sec/cm3 0.000000 1 1 S01-02
23 Khe Hepatocellular tissue uptake rate 0.103689 mL/sec/cm3 0.000000 1 1 S01-02
24 kbh Biliary excretion rate 0.002998 mL/sec/cm3 0.000000 1 1 S01-02
25 E Liver extraction fraction 0.519944 0.000000 1 1 S01-02
26 Ktrans Hepatic plasma clearance 0.011449 mL/sec/cm3 0.000000 1 1 S01-02
27 H Hematocrit 0.418000 0.000000 1 2 S01-02
28 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-02
29 khe Hepatocellular uptake rate 0.022991 mL/sec/cm3 0.002509 1 2 S01-02
30 Th Hepatocellular mean transit time 257.543111 sec 30.531118 1 2 S01-02
31 Kbh Biliary tissue excretion rate 0.003883 mL/sec/cm3 0.000000 1 2 S01-02
32 Khe Hepatocellular tissue uptake rate 0.099963 mL/sec/cm3 0.000000 1 2 S01-02
33 kbh Biliary excretion rate 0.002990 mL/sec/cm3 0.000000 1 2 S01-02
34 E Liver extraction fraction 0.510802 0.000000 1 2 S01-02
35 Ktrans Hepatic plasma clearance 0.011247 mL/sec/cm3 0.000000 1 2 S01-02
36 H Hematocrit 0.418000 0.000000 1 1 S01-03
37 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-03
38 khe Hepatocellular uptake rate 0.021201 mL/sec/cm3 0.001935 1 1 S01-03
39 Th Hepatocellular mean transit time 252.047161 sec 25.047422 1 1 S01-03
40 Kbh Biliary tissue excretion rate 0.003968 mL/sec/cm3 0.000000 1 1 S01-03
41 Khe Hepatocellular tissue uptake rate 0.092177 mL/sec/cm3 0.000000 1 1 S01-03
42 kbh Biliary excretion rate 0.003055 mL/sec/cm3 0.000000 1 1 S01-03
43 E Liver extraction fraction 0.490534 0.000000 1 1 S01-03
44 Ktrans Hepatic plasma clearance 0.010801 mL/sec/cm3 0.000000 1 1 S01-03
45 H Hematocrit 0.418000 0.000000 1 2 S01-03
46 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-03
47 khe Hepatocellular uptake rate 0.018110 mL/sec/cm3 0.000747 1 2 S01-03
48 Th Hepatocellular mean transit time 387.301380 sec 18.829879 1 2 S01-03
49 Kbh Biliary tissue excretion rate 0.002582 mL/sec/cm3 0.000000 1 2 S01-03
50 Khe Hepatocellular tissue uptake rate 0.078739 mL/sec/cm3 0.000000 1 2 S01-03
51 kbh Biliary excretion rate 0.001988 mL/sec/cm3 0.000000 1 2 S01-03
52 E Liver extraction fraction 0.451296 0.000000 1 2 S01-03
53 Ktrans Hepatic plasma clearance 0.009937 mL/sec/cm3 0.000000 1 2 S01-03
54 H Hematocrit 0.418000 0.000000 1 1 S01-04
55 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-04
56 khe Hepatocellular uptake rate 0.011768 mL/sec/cm3 0.001066 1 1 S01-04
57 Th Hepatocellular mean transit time 400.522269 sec 43.897894 1 1 S01-04
58 Kbh Biliary tissue excretion rate 0.002497 mL/sec/cm3 0.000000 1 1 S01-04
59 Khe Hepatocellular tissue uptake rate 0.051165 mL/sec/cm3 0.000000 1 1 S01-04
60 kbh Biliary excretion rate 0.001922 mL/sec/cm3 0.000000 1 1 S01-04
61 E Liver extraction fraction 0.348299 0.000000 1 1 S01-04
62 Ktrans Hepatic plasma clearance 0.007669 mL/sec/cm3 0.000000 1 1 S01-04
63 H Hematocrit 0.418000 0.000000 1 2 S01-04
64 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-04
65 khe Hepatocellular uptake rate 0.006274 mL/sec/cm3 0.000476 1 2 S01-04
66 Th Hepatocellular mean transit time 686.958253 sec 79.663045 1 2 S01-04
67 Kbh Biliary tissue excretion rate 0.001456 mL/sec/cm3 0.000000 1 2 S01-04
68 Khe Hepatocellular tissue uptake rate 0.027280 mL/sec/cm3 0.000000 1 2 S01-04
69 kbh Biliary excretion rate 0.001121 mL/sec/cm3 0.000000 1 2 S01-04
70 E Liver extraction fraction 0.221764 0.000000 1 2 S01-04
71 Ktrans Hepatic plasma clearance 0.004883 mL/sec/cm3 0.000000 1 2 S01-04
72 H Hematocrit 0.418000 0.000000 1 1 S01-05
73 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-05
74 khe Hepatocellular uptake rate 0.025264 mL/sec/cm3 0.003318 1 1 S01-05
75 Th Hepatocellular mean transit time 204.782430 sec 28.619821 1 1 S01-05
76 Kbh Biliary tissue excretion rate 0.004883 mL/sec/cm3 0.000000 1 1 S01-05
77 Khe Hepatocellular tissue uptake rate 0.109844 mL/sec/cm3 0.000000 1 1 S01-05
78 kbh Biliary excretion rate 0.003760 mL/sec/cm3 0.000000 1 1 S01-05
79 E Liver extraction fraction 0.534316 0.000000 1 1 S01-05
80 Ktrans Hepatic plasma clearance 0.011765 mL/sec/cm3 0.000000 1 1 S01-05
81 H Hematocrit 0.418000 0.000000 1 2 S01-05
82 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-05
83 khe Hepatocellular uptake rate 0.003006 mL/sec/cm3 0.000416 1 2 S01-05
84 Th Hepatocellular mean transit time 686.843798 sec 146.465310 1 2 S01-05
85 Kbh Biliary tissue excretion rate 0.001456 mL/sec/cm3 0.000000 1 2 S01-05
86 Khe Hepatocellular tissue uptake rate 0.013069 mL/sec/cm3 0.000000 1 2 S01-05
87 kbh Biliary excretion rate 0.001121 mL/sec/cm3 0.000000 1 2 S01-05
88 E Liver extraction fraction 0.120119 0.000000 1 2 S01-05
89 Ktrans Hepatic plasma clearance 0.002645 mL/sec/cm3 0.000000 1 2 S01-05
90 H Hematocrit 0.418000 0.000000 1 1 S01-06
91 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-06
92 khe Hepatocellular uptake rate 0.020590 mL/sec/cm3 0.002698 1 1 S01-06
93 Th Hepatocellular mean transit time 231.844674 sec 32.910379 1 1 S01-06
94 Kbh Biliary tissue excretion rate 0.004313 mL/sec/cm3 0.000000 1 1 S01-06
95 Khe Hepatocellular tissue uptake rate 0.089523 mL/sec/cm3 0.000000 1 1 S01-06
96 kbh Biliary excretion rate 0.003321 mL/sec/cm3 0.000000 1 1 S01-06
97 E Liver extraction fraction 0.483235 0.000000 1 1 S01-06
98 Ktrans Hepatic plasma clearance 0.010640 mL/sec/cm3 0.000000 1 1 S01-06
99 H Hematocrit 0.418000 0.000000 1 2 S01-06
100 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-06
101 khe Hepatocellular uptake rate 0.004487 mL/sec/cm3 0.000537 1 2 S01-06
102 Th Hepatocellular mean transit time 542.548884 sec 88.978158 1 2 S01-06
103 Kbh Biliary tissue excretion rate 0.001843 mL/sec/cm3 0.000000 1 2 S01-06
104 Khe Hepatocellular tissue uptake rate 0.019511 mL/sec/cm3 0.000000 1 2 S01-06
105 kbh Biliary excretion rate 0.001419 mL/sec/cm3 0.000000 1 2 S01-06
106 E Liver extraction fraction 0.169296 0.000000 1 2 S01-06
107 Ktrans Hepatic plasma clearance 0.003728 mL/sec/cm3 0.000000 1 2 S01-06
108 H Hematocrit 0.418000 0.000000 2 1 S02-01
109 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-01
110 khe Hepatocellular uptake rate 0.037456 mL/sec/cm3 0.002278 2 1 S02-01
111 Th Hepatocellular mean transit time 263.343114 sec 17.126326 2 1 S02-01
112 Kbh Biliary tissue excretion rate 0.003797 mL/sec/cm3 0.000000 2 1 S02-01
113 Khe Hepatocellular tissue uptake rate 0.162851 mL/sec/cm3 0.000000 2 1 S02-01
114 kbh Biliary excretion rate 0.002924 mL/sec/cm3 0.000000 2 1 S02-01
115 E Liver extraction fraction 0.629775 0.000000 2 1 S02-01
116 Ktrans Hepatic plasma clearance 0.013867 mL/sec/cm3 0.000000 2 1 S02-01
117 H Hematocrit 0.418000 0.000000 2 2 S02-01
118 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-01
119 khe Hepatocellular uptake rate 0.009023 mL/sec/cm3 0.000715 2 2 S02-01
120 Th Hepatocellular mean transit time 274.650138 sec 24.787812 2 2 S02-01
121 Kbh Biliary tissue excretion rate 0.003641 mL/sec/cm3 0.000000 2 2 S02-01
122 Khe Hepatocellular tissue uptake rate 0.039232 mL/sec/cm3 0.000000 2 2 S02-01
123 kbh Biliary excretion rate 0.002804 mL/sec/cm3 0.000000 2 2 S02-01
124 E Liver extraction fraction 0.290678 0.000000 2 2 S02-01
125 Ktrans Hepatic plasma clearance 0.006400 mL/sec/cm3 0.000000 2 2 S02-01
126 H Hematocrit 0.418000 0.000000 2 1 S02-02
127 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-02
128 khe Hepatocellular uptake rate 0.046177 mL/sec/cm3 0.006077 2 1 S02-02
129 Th Hepatocellular mean transit time 144.766839 sec 19.640891 2 1 S02-02
130 Kbh Biliary tissue excretion rate 0.006908 mL/sec/cm3 0.000000 2 1 S02-02
131 Khe Hepatocellular tissue uptake rate 0.200771 mL/sec/cm3 0.000000 2 1 S02-02
132 kbh Biliary excretion rate 0.005319 mL/sec/cm3 0.000000 2 1 S02-02
133 E Liver extraction fraction 0.677124 0.000000 2 1 S02-02
134 Ktrans Hepatic plasma clearance 0.014910 mL/sec/cm3 0.000000 2 1 S02-02
135 H Hematocrit 0.418000 0.000000 2 2 S02-02
136 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-02
137 khe Hepatocellular uptake rate 0.026697 mL/sec/cm3 0.001284 2 2 S02-02
138 Th Hepatocellular mean transit time 268.686517 sec 14.131291 2 2 S02-02
139 Kbh Biliary tissue excretion rate 0.003722 mL/sec/cm3 0.000000 2 2 S02-02
140 Khe Hepatocellular tissue uptake rate 0.116073 mL/sec/cm3 0.000000 2 2 S02-02
141 kbh Biliary excretion rate 0.002866 mL/sec/cm3 0.000000 2 2 S02-02
142 E Liver extraction fraction 0.548011 0.000000 2 2 S02-02
143 Ktrans Hepatic plasma clearance 0.012067 mL/sec/cm3 0.000000 2 2 S02-02
144 H Hematocrit 0.418000 0.000000 2 1 S02-03
145 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-03
146 khe Hepatocellular uptake rate 0.042474 mL/sec/cm3 0.003649 2 1 S02-03
147 Th Hepatocellular mean transit time 155.541749 sec 13.858278 2 1 S02-03
148 Kbh Biliary tissue excretion rate 0.006429 mL/sec/cm3 0.000000 2 1 S02-03
149 Khe Hepatocellular tissue uptake rate 0.184670 mL/sec/cm3 0.000000 2 1 S02-03
150 kbh Biliary excretion rate 0.004950 mL/sec/cm3 0.000000 2 1 S02-03
151 E Liver extraction fraction 0.658583 0.000000 2 1 S02-03
152 Ktrans Hepatic plasma clearance 0.014501 mL/sec/cm3 0.000000 2 1 S02-03
153 H Hematocrit 0.418000 0.000000 2 2 S02-03
154 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-03
155 khe Hepatocellular uptake rate 0.029353 mL/sec/cm3 0.002311 2 2 S02-03
156 Th Hepatocellular mean transit time 167.336098 sec 13.963931 2 2 S02-03
157 Kbh Biliary tissue excretion rate 0.005976 mL/sec/cm3 0.000000 2 2 S02-03
158 Khe Hepatocellular tissue uptake rate 0.127621 mL/sec/cm3 0.000000 2 2 S02-03
159 kbh Biliary excretion rate 0.004602 mL/sec/cm3 0.000000 2 2 S02-03
160 E Liver extraction fraction 0.571380 0.000000 2 2 S02-03
161 Ktrans Hepatic plasma clearance 0.012581 mL/sec/cm3 0.000000 2 2 S02-03
162 H Hematocrit 0.418000 0.000000 2 1 S02-04
163 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-04
164 khe Hepatocellular uptake rate 0.024410 mL/sec/cm3 0.001687 2 1 S02-04
165 Th Hepatocellular mean transit time 177.208076 sec 13.113188 2 1 S02-04
166 Kbh Biliary tissue excretion rate 0.005643 mL/sec/cm3 0.000000 2 1 S02-04
167 Khe Hepatocellular tissue uptake rate 0.106131 mL/sec/cm3 0.000000 2 1 S02-04
168 kbh Biliary excretion rate 0.004345 mL/sec/cm3 0.000000 2 1 S02-04
169 E Liver extraction fraction 0.525751 0.000000 2 1 S02-04
170 Ktrans Hepatic plasma clearance 0.011577 mL/sec/cm3 0.000000 2 1 S02-04
171 H Hematocrit 0.418000 0.000000 2 2 S02-04
172 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-04
173 khe Hepatocellular uptake rate 0.001967 mL/sec/cm3 0.000277 2 2 S02-04
174 Th Hepatocellular mean transit time 679.796147 sec 146.813853 2 2 S02-04
175 Kbh Biliary tissue excretion rate 0.001471 mL/sec/cm3 0.000000 2 2 S02-04
176 Khe Hepatocellular tissue uptake rate 0.008554 mL/sec/cm3 0.000000 2 2 S02-04
177 kbh Biliary excretion rate 0.001133 mL/sec/cm3 0.000000 2 2 S02-04
178 E Liver extraction fraction 0.082020 0.000000 2 2 S02-04
179 Ktrans Hepatic plasma clearance 0.001806 mL/sec/cm3 0.000000 2 2 S02-04
180 H Hematocrit 0.418000 0.000000 2 1 S02-05
181 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-05
182 khe Hepatocellular uptake rate 0.015335 mL/sec/cm3 0.001688 2 1 S02-05
183 Th Hepatocellular mean transit time 138.623210 sec 16.490173 2 1 S02-05
184 Kbh Biliary tissue excretion rate 0.007214 mL/sec/cm3 0.000000 2 1 S02-05
185 Khe Hepatocellular tissue uptake rate 0.066675 mL/sec/cm3 0.000000 2 1 S02-05
186 kbh Biliary excretion rate 0.005555 mL/sec/cm3 0.000000 2 1 S02-05
187 E Liver extraction fraction 0.410535 0.000000 2 1 S02-05
188 Ktrans Hepatic plasma clearance 0.009040 mL/sec/cm3 0.000000 2 1 S02-05
189 H Hematocrit 0.418000 0.000000 2 2 S02-05
190 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-05
191 khe Hepatocellular uptake rate 0.005066 mL/sec/cm3 0.000557 2 2 S02-05
192 Th Hepatocellular mean transit time 450.426317 sec 63.340137 2 2 S02-05
193 Kbh Biliary tissue excretion rate 0.002220 mL/sec/cm3 0.000000 2 2 S02-05
194 Khe Hepatocellular tissue uptake rate 0.022025 mL/sec/cm3 0.000000 2 2 S02-05
195 kbh Biliary excretion rate 0.001709 mL/sec/cm3 0.000000 2 2 S02-05
196 E Liver extraction fraction 0.187032 0.000000 2 2 S02-05
197 Ktrans Hepatic plasma clearance 0.004118 mL/sec/cm3 0.000000 2 2 S02-05
198 H Hematocrit 0.418000 0.000000 2 1 S02-06
199 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-06
200 khe Hepatocellular uptake rate 0.024746 mL/sec/cm3 0.001155 2 1 S02-06
201 Th Hepatocellular mean transit time 273.994877 sec 14.073563 2 1 S02-06
202 Kbh Biliary tissue excretion rate 0.003650 mL/sec/cm3 0.000000 2 1 S02-06
203 Khe Hepatocellular tissue uptake rate 0.107592 mL/sec/cm3 0.000000 2 1 S02-06
204 kbh Biliary excretion rate 0.002810 mL/sec/cm3 0.000000 2 1 S02-06
205 E Liver extraction fraction 0.529159 0.000000 2 1 S02-06
206 Ktrans Hepatic plasma clearance 0.011652 mL/sec/cm3 0.000000 2 1 S02-06
207 H Hematocrit 0.418000 0.000000 2 2 S02-06
208 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-06
209 khe Hepatocellular uptake rate 0.005382 mL/sec/cm3 0.000350 2 2 S02-06
210 Th Hepatocellular mean transit time 525.282002 sec 46.228462 2 2 S02-06
211 Kbh Biliary tissue excretion rate 0.001904 mL/sec/cm3 0.000000 2 2 S02-06
212 Khe Hepatocellular tissue uptake rate 0.023401 mL/sec/cm3 0.000000 2 2 S02-06
213 kbh Biliary excretion rate 0.001466 mL/sec/cm3 0.000000 2 2 S02-06
214 E Liver extraction fraction 0.196425 0.000000 2 2 S02-06
215 Ktrans Hepatic plasma clearance 0.004325 mL/sec/cm3 0.000000 2 2 S02-06
216 H Hematocrit 0.418000 0.000000 3 1 S03-01
217 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-01
218 khe Hepatocellular uptake rate 0.023941 mL/sec/cm3 0.001109 3 1 S03-01
219 Th Hepatocellular mean transit time 312.895297 sec 16.265444 3 1 S03-01
220 Kbh Biliary tissue excretion rate 0.003196 mL/sec/cm3 0.000000 3 1 S03-01
221 Khe Hepatocellular tissue uptake rate 0.104092 mL/sec/cm3 0.000000 3 1 S03-01
222 kbh Biliary excretion rate 0.002461 mL/sec/cm3 0.000000 3 1 S03-01
223 E Liver extraction fraction 0.520912 0.000000 3 1 S03-01
224 Ktrans Hepatic plasma clearance 0.011470 mL/sec/cm3 0.000000 3 1 S03-01
225 H Hematocrit 0.418000 0.000000 3 2 S03-01
226 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-01
227 khe Hepatocellular uptake rate 0.033963 mL/sec/cm3 0.002174 3 2 S03-01
228 Th Hepatocellular mean transit time 230.341863 sec 15.702421 3 2 S03-01
229 Kbh Biliary tissue excretion rate 0.004341 mL/sec/cm3 0.000000 3 2 S03-01
230 Khe Hepatocellular tissue uptake rate 0.147666 mL/sec/cm3 0.000000 3 2 S03-01
231 kbh Biliary excretion rate 0.003343 mL/sec/cm3 0.000000 3 2 S03-01
232 E Liver extraction fraction 0.606679 0.000000 3 2 S03-01
233 Ktrans Hepatic plasma clearance 0.013358 mL/sec/cm3 0.000000 3 2 S03-01
234 H Hematocrit 0.418000 0.000000 3 1 S03-02
235 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-02
236 khe Hepatocellular uptake rate 0.027175 mL/sec/cm3 0.001716 3 1 S03-02
237 Th Hepatocellular mean transit time 321.094122 sec 22.705135 3 1 S03-02
238 Kbh Biliary tissue excretion rate 0.003114 mL/sec/cm3 0.000000 3 1 S03-02
239 Khe Hepatocellular tissue uptake rate 0.118154 mL/sec/cm3 0.000000 3 1 S03-02
240 kbh Biliary excretion rate 0.002398 mL/sec/cm3 0.000000 3 1 S03-02
241 E Liver extraction fraction 0.552408 0.000000 3 1 S03-02
242 Ktrans Hepatic plasma clearance 0.012163 mL/sec/cm3 0.000000 3 1 S03-02
243 H Hematocrit 0.418000 0.000000 3 2 S03-02
244 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-02
245 khe Hepatocellular uptake rate 0.018935 mL/sec/cm3 0.002050 3 2 S03-02
246 Th Hepatocellular mean transit time 384.012709 sec 49.227981 3 2 S03-02
247 Kbh Biliary tissue excretion rate 0.002604 mL/sec/cm3 0.000000 3 2 S03-02
248 Khe Hepatocellular tissue uptake rate 0.082324 mL/sec/cm3 0.000000 3 2 S03-02
249 kbh Biliary excretion rate 0.002005 mL/sec/cm3 0.000000 3 2 S03-02
250 E Liver extraction fraction 0.462343 0.000000 3 2 S03-02
251 Ktrans Hepatic plasma clearance 0.010180 mL/sec/cm3 0.000000 3 2 S03-02
252 H Hematocrit 0.418000 0.000000 3 1 S03-03
253 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-03
254 khe Hepatocellular uptake rate 0.021655 mL/sec/cm3 0.000687 3 1 S03-03
255 Th Hepatocellular mean transit time 321.596201 sec 11.561816 3 1 S03-03
256 Kbh Biliary tissue excretion rate 0.003109 mL/sec/cm3 0.000000 3 1 S03-03
257 Khe Hepatocellular tissue uptake rate 0.094154 mL/sec/cm3 0.000000 3 1 S03-03
258 kbh Biliary excretion rate 0.002394 mL/sec/cm3 0.000000 3 1 S03-03
259 E Liver extraction fraction 0.495837 0.000000 3 1 S03-03
260 Ktrans Hepatic plasma clearance 0.010918 mL/sec/cm3 0.000000 3 1 S03-03
261 H Hematocrit 0.418000 0.000000 3 2 S03-03
262 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-03
263 khe Hepatocellular uptake rate 0.017680 mL/sec/cm3 0.001322 3 2 S03-03
264 Th Hepatocellular mean transit time 277.464317 sec 23.208925 3 2 S03-03
265 Kbh Biliary tissue excretion rate 0.003604 mL/sec/cm3 0.000000 3 2 S03-03
266 Khe Hepatocellular tissue uptake rate 0.076871 mL/sec/cm3 0.000000 3 2 S03-03
267 kbh Biliary excretion rate 0.002775 mL/sec/cm3 0.000000 3 2 S03-03
268 E Liver extraction fraction 0.445355 0.000000 3 2 S03-03
269 Ktrans Hepatic plasma clearance 0.009806 mL/sec/cm3 0.000000 3 2 S03-03
270 H Hematocrit 0.418000 0.000000 3 1 S03-04
271 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-04
272 khe Hepatocellular uptake rate 0.034099 mL/sec/cm3 0.002864 3 1 S03-04
273 Th Hepatocellular mean transit time 281.768411 sec 25.651358 3 1 S03-04
274 Kbh Biliary tissue excretion rate 0.003549 mL/sec/cm3 0.000000 3 1 S03-04
275 Khe Hepatocellular tissue uptake rate 0.148255 mL/sec/cm3 0.000000 3 1 S03-04
276 kbh Biliary excretion rate 0.002733 mL/sec/cm3 0.000000 3 1 S03-04
277 E Liver extraction fraction 0.607628 0.000000 3 1 S03-04
278 Ktrans Hepatic plasma clearance 0.013379 mL/sec/cm3 0.000000 3 1 S03-04
279 H Hematocrit 0.418000 0.000000 3 2 S03-04
280 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-04
281 khe Hepatocellular uptake rate 0.000876 mL/sec/cm3 0.000235 3 2 S03-04
282 Th Hepatocellular mean transit time 55013.106762 sec 919963.195838 3 2 S03-04
283 Kbh Biliary tissue excretion rate 0.000018 mL/sec/cm3 0.000000 3 2 S03-04
284 Khe Hepatocellular tissue uptake rate 0.003808 mL/sec/cm3 0.000000 3 2 S03-04
285 kbh Biliary excretion rate 0.000014 mL/sec/cm3 0.000000 3 2 S03-04
286 E Liver extraction fraction 0.038258 0.000000 3 2 S03-04
287 Ktrans Hepatic plasma clearance 0.000842 mL/sec/cm3 0.000000 3 2 S03-04
288 H Hematocrit 0.418000 0.000000 3 1 S03-05
289 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-05
290 khe Hepatocellular uptake rate 0.019348 mL/sec/cm3 0.001308 3 1 S03-05
291 Th Hepatocellular mean transit time 274.149443 sec 20.997595 3 1 S03-05
292 Kbh Biliary tissue excretion rate 0.003648 mL/sec/cm3 0.000000 3 1 S03-05
293 Khe Hepatocellular tissue uptake rate 0.084123 mL/sec/cm3 0.000000 3 1 S03-05
294 kbh Biliary excretion rate 0.002809 mL/sec/cm3 0.000000 3 1 S03-05
295 E Liver extraction fraction 0.467720 0.000000 3 1 S03-05
296 Ktrans Hepatic plasma clearance 0.010299 mL/sec/cm3 0.000000 3 1 S03-05
297 H Hematocrit 0.418000 0.000000 3 2 S03-05
298 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-05
299 khe Hepatocellular uptake rate 0.002630 mL/sec/cm3 0.000265 3 2 S03-05
300 Th Hepatocellular mean transit time 2165.011101 sec 806.084509 3 2 S03-05
301 Kbh Biliary tissue excretion rate 0.000462 mL/sec/cm3 0.000000 3 2 S03-05
302 Khe Hepatocellular tissue uptake rate 0.011434 mL/sec/cm3 0.000000 3 2 S03-05
303 kbh Biliary excretion rate 0.000356 mL/sec/cm3 0.000000 3 2 S03-05
304 E Liver extraction fraction 0.106695 0.000000 3 2 S03-05
305 Ktrans Hepatic plasma clearance 0.002349 mL/sec/cm3 0.000000 3 2 S03-05
306 H Hematocrit 0.418000 0.000000 3 1 S03-06
307 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-06
308 khe Hepatocellular uptake rate 0.018785 mL/sec/cm3 0.001447 3 1 S03-06
309 Th Hepatocellular mean transit time 361.925824 sec 34.299076 3 1 S03-06
310 Kbh Biliary tissue excretion rate 0.002763 mL/sec/cm3 0.000000 3 1 S03-06
311 Khe Hepatocellular tissue uptake rate 0.081674 mL/sec/cm3 0.000000 3 1 S03-06
312 kbh Biliary excretion rate 0.002128 mL/sec/cm3 0.000000 3 1 S03-06
313 E Liver extraction fraction 0.460371 0.000000 3 1 S03-06
314 Ktrans Hepatic plasma clearance 0.010137 mL/sec/cm3 0.000000 3 1 S03-06
315 H Hematocrit 0.418000 0.000000 3 2 S03-06
316 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-06
317 khe Hepatocellular uptake rate 0.002557 mL/sec/cm3 0.000266 3 2 S03-06
318 Th Hepatocellular mean transit time 1882.214105 sec 616.849046 3 2 S03-06
319 Kbh Biliary tissue excretion rate 0.000531 mL/sec/cm3 0.000000 3 2 S03-06
320 Khe Hepatocellular tissue uptake rate 0.011115 mL/sec/cm3 0.000000 3 2 S03-06
321 kbh Biliary excretion rate 0.000409 mL/sec/cm3 0.000000 3 2 S03-06
322 E Liver extraction fraction 0.104028 0.000000 3 2 S03-06
323 Ktrans Hepatic plasma clearance 0.002291 mL/sec/cm3 0.000000 3 2 S03-06
324 H Hematocrit 0.418000 0.000000 4 1 S04-01
325 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-01
326 khe Hepatocellular uptake rate 0.021087 mL/sec/cm3 0.001305 4 1 S04-01
327 Th Hepatocellular mean transit time 297.370715 sec 20.396250 4 1 S04-01
328 Kbh Biliary tissue excretion rate 0.003363 mL/sec/cm3 0.000000 4 1 S04-01
329 Khe Hepatocellular tissue uptake rate 0.091683 mL/sec/cm3 0.000000 4 1 S04-01
330 kbh Biliary excretion rate 0.002589 mL/sec/cm3 0.000000 4 1 S04-01
331 E Liver extraction fraction 0.489189 0.000000 4 1 S04-01
332 Ktrans Hepatic plasma clearance 0.010771 mL/sec/cm3 0.000000 4 1 S04-01
333 H Hematocrit 0.418000 0.000000 4 2 S04-01
334 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-01
335 khe Hepatocellular uptake rate 0.025377 mL/sec/cm3 0.001401 4 2 S04-01
336 Th Hepatocellular mean transit time 392.007671 sec 25.091818 4 2 S04-01
337 Kbh Biliary tissue excretion rate 0.002551 mL/sec/cm3 0.000000 4 2 S04-01
338 Khe Hepatocellular tissue uptake rate 0.110335 mL/sec/cm3 0.000000 4 2 S04-01
339 kbh Biliary excretion rate 0.001964 mL/sec/cm3 0.000000 4 2 S04-01
340 E Liver extraction fraction 0.535425 0.000000 4 2 S04-01
341 Ktrans Hepatic plasma clearance 0.011790 mL/sec/cm3 0.000000 4 2 S04-01
342 H Hematocrit 0.418000 0.000000 4 1 S04-02
343 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-02
344 khe Hepatocellular uptake rate 0.018752 mL/sec/cm3 0.001563 4 1 S04-02
345 Th Hepatocellular mean transit time 270.765508 sec 24.867642 4 1 S04-02
346 Kbh Biliary tissue excretion rate 0.003693 mL/sec/cm3 0.000000 4 1 S04-02
347 Khe Hepatocellular tissue uptake rate 0.081531 mL/sec/cm3 0.000000 4 1 S04-02
348 kbh Biliary excretion rate 0.002844 mL/sec/cm3 0.000000 4 1 S04-02
349 E Liver extraction fraction 0.459936 0.000000 4 1 S04-02
350 Ktrans Hepatic plasma clearance 0.010127 mL/sec/cm3 0.000000 4 1 S04-02
351 H Hematocrit 0.418000 0.000000 4 2 S04-02
352 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-02
353 khe Hepatocellular uptake rate 0.026179 mL/sec/cm3 0.001797 4 2 S04-02
354 Th Hepatocellular mean transit time 213.594857 sec 15.576389 4 2 S04-02
355 Kbh Biliary tissue excretion rate 0.004682 mL/sec/cm3 0.000000 4 2 S04-02
356 Khe Hepatocellular tissue uptake rate 0.113824 mL/sec/cm3 0.000000 4 2 S04-02
357 kbh Biliary excretion rate 0.003605 mL/sec/cm3 0.000000 4 2 S04-02
358 E Liver extraction fraction 0.543160 0.000000 4 2 S04-02
359 Ktrans Hepatic plasma clearance 0.011960 mL/sec/cm3 0.000000 4 2 S04-02
360 H Hematocrit 0.418000 0.000000 4 1 S04-03
361 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-03
362 khe Hepatocellular uptake rate 0.030745 mL/sec/cm3 0.002625 4 1 S04-03
363 Th Hepatocellular mean transit time 164.766512 sec 14.686232 4 1 S04-03
364 Kbh Biliary tissue excretion rate 0.006069 mL/sec/cm3 0.000000 4 1 S04-03
365 Khe Hepatocellular tissue uptake rate 0.133676 mL/sec/cm3 0.000000 4 1 S04-03
366 kbh Biliary excretion rate 0.004673 mL/sec/cm3 0.000000 4 1 S04-03
367 E Liver extraction fraction 0.582692 0.000000 4 1 S04-03
368 Ktrans Hepatic plasma clearance 0.012830 mL/sec/cm3 0.000000 4 1 S04-03
369 H Hematocrit 0.418000 0.000000 4 2 S04-03
370 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-03
371 khe Hepatocellular uptake rate 0.032307 mL/sec/cm3 0.002462 4 2 S04-03
372 Th Hepatocellular mean transit time 199.347152 sec 15.884694 4 2 S04-03
373 Kbh Biliary tissue excretion rate 0.005016 mL/sec/cm3 0.000000 4 2 S04-03
374 Khe Hepatocellular tissue uptake rate 0.140467 mL/sec/cm3 0.000000 4 2 S04-03
375 kbh Biliary excretion rate 0.003863 mL/sec/cm3 0.000000 4 2 S04-03
376 E Liver extraction fraction 0.594691 0.000000 4 2 S04-03
377 Ktrans Hepatic plasma clearance 0.013095 mL/sec/cm3 0.000000 4 2 S04-03
378 H Hematocrit 0.418000 0.000000 4 1 S04-04
379 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-04
380 khe Hepatocellular uptake rate 0.025308 mL/sec/cm3 0.001942 4 1 S04-04
381 Th Hepatocellular mean transit time 212.831818 sec 17.383364 4 1 S04-04
382 Kbh Biliary tissue excretion rate 0.004699 mL/sec/cm3 0.000000 4 1 S04-04
383 Khe Hepatocellular tissue uptake rate 0.110034 mL/sec/cm3 0.000000 4 1 S04-04
384 kbh Biliary excretion rate 0.003618 mL/sec/cm3 0.000000 4 1 S04-04
385 E Liver extraction fraction 0.534747 0.000000 4 1 S04-04
386 Ktrans Hepatic plasma clearance 0.011775 mL/sec/cm3 0.000000 4 1 S04-04
387 H Hematocrit 0.418000 0.000000 4 2 S04-04
388 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-04
389 khe Hepatocellular uptake rate 0.032058 mL/sec/cm3 0.001538 4 2 S04-04
390 Th Hepatocellular mean transit time 219.238595 sec 11.046538 4 2 S04-04
391 Kbh Biliary tissue excretion rate 0.004561 mL/sec/cm3 0.000000 4 2 S04-04
392 Khe Hepatocellular tissue uptake rate 0.139382 mL/sec/cm3 0.000000 4 2 S04-04
393 kbh Biliary excretion rate 0.003512 mL/sec/cm3 0.000000 4 2 S04-04
394 E Liver extraction fraction 0.592820 0.000000 4 2 S04-04
395 Ktrans Hepatic plasma clearance 0.013053 mL/sec/cm3 0.000000 4 2 S04-04
396 H Hematocrit 0.418000 0.000000 4 1 S04-05
397 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-05
398 khe Hepatocellular uptake rate 0.023628 mL/sec/cm3 0.001367 4 1 S04-05
399 Th Hepatocellular mean transit time 315.200292 sec 20.265161 4 1 S04-05
400 Kbh Biliary tissue excretion rate 0.003173 mL/sec/cm3 0.000000 4 1 S04-05
401 Khe Hepatocellular tissue uptake rate 0.102733 mL/sec/cm3 0.000000 4 1 S04-05
402 kbh Biliary excretion rate 0.002443 mL/sec/cm3 0.000000 4 1 S04-05
403 E Liver extraction fraction 0.517630 0.000000 4 1 S04-05
404 Ktrans Hepatic plasma clearance 0.011398 mL/sec/cm3 0.000000 4 1 S04-05
405 H Hematocrit 0.418000 0.000000 4 2 S04-05
406 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-05
407 khe Hepatocellular uptake rate 0.006623 mL/sec/cm3 0.000644 4 2 S04-05
408 Th Hepatocellular mean transit time 805.977488 sec 131.120090 4 2 S04-05
409 Kbh Biliary tissue excretion rate 0.001241 mL/sec/cm3 0.000000 4 2 S04-05
410 Khe Hepatocellular tissue uptake rate 0.028797 mL/sec/cm3 0.000000 4 2 S04-05
411 kbh Biliary excretion rate 0.000955 mL/sec/cm3 0.000000 4 2 S04-05
412 E Liver extraction fraction 0.231241 0.000000 4 2 S04-05
413 Ktrans Hepatic plasma clearance 0.005092 mL/sec/cm3 0.000000 4 2 S04-05
414 H Hematocrit 0.418000 0.000000 4 1 S04-06
415 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-06
416 khe Hepatocellular uptake rate 0.026667 mL/sec/cm3 0.001716 4 1 S04-06
417 Th Hepatocellular mean transit time 199.571416 sec 13.588116 4 1 S04-06
418 Kbh Biliary tissue excretion rate 0.005011 mL/sec/cm3 0.000000 4 1 S04-06
419 Khe Hepatocellular tissue uptake rate 0.115942 mL/sec/cm3 0.000000 4 1 S04-06
420 kbh Biliary excretion rate 0.003858 mL/sec/cm3 0.000000 4 1 S04-06
421 E Liver extraction fraction 0.547731 0.000000 4 1 S04-06
422 Ktrans Hepatic plasma clearance 0.012060 mL/sec/cm3 0.000000 4 1 S04-06
423 H Hematocrit 0.418000 0.000000 4 2 S04-06
424 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-06
425 khe Hepatocellular uptake rate 0.005094 mL/sec/cm3 0.000428 4 2 S04-06
426 Th Hepatocellular mean transit time 577.583373 sec 68.126327 4 2 S04-06
427 Kbh Biliary tissue excretion rate 0.001731 mL/sec/cm3 0.000000 4 2 S04-06
428 Khe Hepatocellular tissue uptake rate 0.022147 mL/sec/cm3 0.000000 4 2 S04-06
429 kbh Biliary excretion rate 0.001333 mL/sec/cm3 0.000000 4 2 S04-06
430 E Liver extraction fraction 0.187878 0.000000 4 2 S04-06
431 Ktrans Hepatic plasma clearance 0.004137 mL/sec/cm3 0.000000 4 2 S04-06
432 H Hematocrit 0.418000 0.000000 4 1 S04-07
433 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-07
434 khe Hepatocellular uptake rate 0.029360 mL/sec/cm3 0.001784 4 1 S04-07
435 Th Hepatocellular mean transit time 197.235571 sec 12.603995 4 1 S04-07
436 Kbh Biliary tissue excretion rate 0.005070 mL/sec/cm3 0.000000 4 1 S04-07
437 Khe Hepatocellular tissue uptake rate 0.127652 mL/sec/cm3 0.000000 4 1 S04-07
438 kbh Biliary excretion rate 0.003904 mL/sec/cm3 0.000000 4 1 S04-07
439 E Liver extraction fraction 0.571440 0.000000 4 1 S04-07
440 Ktrans Hepatic plasma clearance 0.012583 mL/sec/cm3 0.000000 4 1 S04-07
441 H Hematocrit 0.418000 0.000000 4 2 S04-07
442 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-07
443 khe Hepatocellular uptake rate 0.006850 mL/sec/cm3 0.000602 4 2 S04-07
444 Th Hepatocellular mean transit time 579.373538 sec 71.310385 4 2 S04-07
445 Kbh Biliary tissue excretion rate 0.001726 mL/sec/cm3 0.000000 4 2 S04-07
446 Khe Hepatocellular tissue uptake rate 0.029783 mL/sec/cm3 0.000000 4 2 S04-07
447 kbh Biliary excretion rate 0.001329 mL/sec/cm3 0.000000 4 2 S04-07
448 E Liver extraction fraction 0.237280 0.000000 4 2 S04-07
449 Ktrans Hepatic plasma clearance 0.005225 mL/sec/cm3 0.000000 4 2 S04-07
450 H Hematocrit 0.418000 0.000000 4 1 S04-08
451 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-08
452 khe Hepatocellular uptake rate 0.022104 mL/sec/cm3 0.001318 4 1 S04-08
453 Th Hepatocellular mean transit time 210.515733 sec 13.455461 4 1 S04-08
454 Kbh Biliary tissue excretion rate 0.004750 mL/sec/cm3 0.000000 4 1 S04-08
455 Khe Hepatocellular tissue uptake rate 0.096104 mL/sec/cm3 0.000000 4 1 S04-08
456 kbh Biliary excretion rate 0.003658 mL/sec/cm3 0.000000 4 1 S04-08
457 E Liver extraction fraction 0.500962 0.000000 4 1 S04-08
458 Ktrans Hepatic plasma clearance 0.011031 mL/sec/cm3 0.000000 4 1 S04-08
459 H Hematocrit 0.418000 0.000000 4 2 S04-08
460 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-08
461 khe Hepatocellular uptake rate 0.006882 mL/sec/cm3 0.000653 4 2 S04-08
462 Th Hepatocellular mean transit time 640.608373 sec 89.393651 4 2 S04-08
463 Kbh Biliary tissue excretion rate 0.001561 mL/sec/cm3 0.000000 4 2 S04-08
464 Khe Hepatocellular tissue uptake rate 0.029924 mL/sec/cm3 0.000000 4 2 S04-08
465 kbh Biliary excretion rate 0.001202 mL/sec/cm3 0.000000 4 2 S04-08
466 E Liver extraction fraction 0.238136 0.000000 4 2 S04-08
467 Ktrans Hepatic plasma clearance 0.005244 mL/sec/cm3 0.000000 4 2 S04-08
468 H Hematocrit 0.418000 0.000000 5 1 S05-01
469 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-01
470 khe Hepatocellular uptake rate 0.027315 mL/sec/cm3 0.001681 5 1 S05-01
471 Th Hepatocellular mean transit time 247.264899 sec 16.488928 5 1 S05-01
472 Kbh Biliary tissue excretion rate 0.004044 mL/sec/cm3 0.000000 5 1 S05-01
473 Khe Hepatocellular tissue uptake rate 0.118762 mL/sec/cm3 0.000000 5 1 S05-01
474 kbh Biliary excretion rate 0.003114 mL/sec/cm3 0.000000 5 1 S05-01
475 E Liver extraction fraction 0.553676 0.000000 5 1 S05-01
476 Ktrans Hepatic plasma clearance 0.012191 mL/sec/cm3 0.000000 5 1 S05-01
477 H Hematocrit 0.418000 0.000000 5 1 S05-02
478 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-02
479 khe Hepatocellular uptake rate 0.029071 mL/sec/cm3 0.000697 5 1 S05-02
480 Th Hepatocellular mean transit time 192.680543 sec 4.917299 5 1 S05-02
481 Kbh Biliary tissue excretion rate 0.005190 mL/sec/cm3 0.000000 5 1 S05-02
482 Khe Hepatocellular tissue uptake rate 0.126397 mL/sec/cm3 0.000000 5 1 S05-02
483 kbh Biliary excretion rate 0.003996 mL/sec/cm3 0.000000 5 1 S05-02
484 E Liver extraction fraction 0.569017 0.000000 5 1 S05-02
485 Ktrans Hepatic plasma clearance 0.012529 mL/sec/cm3 0.000000 5 1 S05-02
486 H Hematocrit 0.418000 0.000000 5 1 S05-03
487 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-03
488 khe Hepatocellular uptake rate 0.022983 mL/sec/cm3 0.002276 5 1 S05-03
489 Th Hepatocellular mean transit time 154.949009 sec 16.413168 5 1 S05-03
490 Kbh Biliary tissue excretion rate 0.006454 mL/sec/cm3 0.000000 5 1 S05-03
491 Khe Hepatocellular tissue uptake rate 0.099925 mL/sec/cm3 0.000000 5 1 S05-03
492 kbh Biliary excretion rate 0.004969 mL/sec/cm3 0.000000 5 1 S05-03
493 E Liver extraction fraction 0.510709 0.000000 5 1 S05-03
494 Ktrans Hepatic plasma clearance 0.011245 mL/sec/cm3 0.000000 5 1 S05-03
495 H Hematocrit 0.418000 0.000000 5 1 S05-04
496 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-04
497 khe Hepatocellular uptake rate 0.017759 mL/sec/cm3 0.000795 5 1 S05-04
498 Th Hepatocellular mean transit time 185.964864 sec 9.040065 5 1 S05-04
499 Kbh Biliary tissue excretion rate 0.005377 mL/sec/cm3 0.000000 5 1 S05-04
500 Khe Hepatocellular tissue uptake rate 0.077215 mL/sec/cm3 0.000000 5 1 S05-04
501 kbh Biliary excretion rate 0.004141 mL/sec/cm3 0.000000 5 1 S05-04
502 E Liver extraction fraction 0.446459 0.000000 5 1 S05-04
503 Ktrans Hepatic plasma clearance 0.009831 mL/sec/cm3 0.000000 5 1 S05-04
504 H Hematocrit 0.418000 0.000000 5 1 S05-05
505 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-05
506 khe Hepatocellular uptake rate 0.015636 mL/sec/cm3 0.001193 5 1 S05-05
507 Th Hepatocellular mean transit time 195.399387 sec 16.291207 5 1 S05-05
508 Kbh Biliary tissue excretion rate 0.005118 mL/sec/cm3 0.000000 5 1 S05-05
509 Khe Hepatocellular tissue uptake rate 0.067983 mL/sec/cm3 0.000000 5 1 S05-05
510 kbh Biliary excretion rate 0.003941 mL/sec/cm3 0.000000 5 1 S05-05
511 E Liver extraction fraction 0.415244 0.000000 5 1 S05-05
512 Ktrans Hepatic plasma clearance 0.009143 mL/sec/cm3 0.000000 5 1 S05-05
513 H Hematocrit 0.418000 0.000000 5 1 S05-06
514 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-06
515 khe Hepatocellular uptake rate 0.017560 mL/sec/cm3 0.001343 5 1 S05-06
516 Th Hepatocellular mean transit time 172.510596 sec 14.285767 5 1 S05-06
517 Kbh Biliary tissue excretion rate 0.005797 mL/sec/cm3 0.000000 5 1 S05-06
518 Khe Hepatocellular tissue uptake rate 0.076347 mL/sec/cm3 0.000000 5 1 S05-06
519 kbh Biliary excretion rate 0.004463 mL/sec/cm3 0.000000 5 1 S05-06
520 E Liver extraction fraction 0.443667 0.000000 5 1 S05-06
521 Ktrans Hepatic plasma clearance 0.009769 mL/sec/cm3 0.000000 5 1 S05-06
522 H Hematocrit 0.418000 0.000000 6 1 S06-01
523 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-01
524 khe Hepatocellular uptake rate 0.022970 mL/sec/cm3 0.001936 6 1 S06-01
525 Th Hepatocellular mean transit time 180.613765 sec 16.350347 6 1 S06-01
526 Kbh Biliary tissue excretion rate 0.005537 mL/sec/cm3 0.000000 6 1 S06-01
527 Khe Hepatocellular tissue uptake rate 0.099870 mL/sec/cm3 0.000000 6 1 S06-01
528 kbh Biliary excretion rate 0.004263 mL/sec/cm3 0.000000 6 1 S06-01
529 E Liver extraction fraction 0.510571 0.000000 6 1 S06-01
530 Ktrans Hepatic plasma clearance 0.011242 mL/sec/cm3 0.000000 6 1 S06-01
531 H Hematocrit 0.418000 0.000000 6 1 S06-02
532 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-02
533 khe Hepatocellular uptake rate 0.029583 mL/sec/cm3 0.001750 6 1 S06-02
534 Th Hepatocellular mean transit time 210.951954 sec 13.326347 6 1 S06-02
535 Kbh Biliary tissue excretion rate 0.004740 mL/sec/cm3 0.000000 6 1 S06-02
536 Khe Hepatocellular tissue uptake rate 0.128623 mL/sec/cm3 0.000000 6 1 S06-02
537 kbh Biliary excretion rate 0.003650 mL/sec/cm3 0.000000 6 1 S06-02
538 E Liver extraction fraction 0.573294 0.000000 6 1 S06-02
539 Ktrans Hepatic plasma clearance 0.012623 mL/sec/cm3 0.000000 6 1 S06-02
540 H Hematocrit 0.418000 0.000000 6 1 S06-03
541 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-03
542 khe Hepatocellular uptake rate 0.025256 mL/sec/cm3 0.002817 6 1 S06-03
543 Th Hepatocellular mean transit time 163.355164 sec 19.432571 6 1 S06-03
544 Kbh Biliary tissue excretion rate 0.006122 mL/sec/cm3 0.000000 6 1 S06-03
545 Khe Hepatocellular tissue uptake rate 0.109808 mL/sec/cm3 0.000000 6 1 S06-03
546 kbh Biliary excretion rate 0.004714 mL/sec/cm3 0.000000 6 1 S06-03
547 E Liver extraction fraction 0.534234 0.000000 6 1 S06-03
548 Ktrans Hepatic plasma clearance 0.011763 mL/sec/cm3 0.000000 6 1 S06-03
549 H Hematocrit 0.418000 0.000000 6 1 S06-04
550 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-04
551 khe Hepatocellular uptake rate 0.020520 mL/sec/cm3 0.001436 6 1 S06-04
552 Th Hepatocellular mean transit time 173.964985 sec 13.119590 6 1 S06-04
553 Kbh Biliary tissue excretion rate 0.005748 mL/sec/cm3 0.000000 6 1 S06-04
554 Khe Hepatocellular tissue uptake rate 0.089218 mL/sec/cm3 0.000000 6 1 S06-04
555 kbh Biliary excretion rate 0.004426 mL/sec/cm3 0.000000 6 1 S06-04
556 E Liver extraction fraction 0.482383 0.000000 6 1 S06-04
557 Ktrans Hepatic plasma clearance 0.010622 mL/sec/cm3 0.000000 6 1 S06-04
558 H Hematocrit 0.418000 0.000000 6 1 S06-05
559 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-05
560 khe Hepatocellular uptake rate 0.019660 mL/sec/cm3 0.001497 6 1 S06-05
561 Th Hepatocellular mean transit time 171.315280 sec 14.074132 6 1 S06-05
562 Kbh Biliary tissue excretion rate 0.005837 mL/sec/cm3 0.000000 6 1 S06-05
563 Khe Hepatocellular tissue uptake rate 0.085477 mL/sec/cm3 0.000000 6 1 S06-05
564 kbh Biliary excretion rate 0.004495 mL/sec/cm3 0.000000 6 1 S06-05
565 E Liver extraction fraction 0.471696 0.000000 6 1 S06-05
566 Ktrans Hepatic plasma clearance 0.010386 mL/sec/cm3 0.000000 6 1 S06-05
567 H Hematocrit 0.418000 0.000000 6 1 S06-06
568 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-06
569 khe Hepatocellular uptake rate 0.020711 mL/sec/cm3 0.001520 6 1 S06-06
570 Th Hepatocellular mean transit time 232.382529 sec 18.636306 6 1 S06-06
571 Kbh Biliary tissue excretion rate 0.004303 mL/sec/cm3 0.000000 6 1 S06-06
572 Khe Hepatocellular tissue uptake rate 0.090047 mL/sec/cm3 0.000000 6 1 S06-06
573 kbh Biliary excretion rate 0.003314 mL/sec/cm3 0.000000 6 1 S06-06
574 E Liver extraction fraction 0.484692 0.000000 6 1 S06-06
575 Ktrans Hepatic plasma clearance 0.010672 mL/sec/cm3 0.000000 6 1 S06-06
576 H Hematocrit 0.418000 0.000000 7 1 S07-01
577 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-01
578 khe Hepatocellular uptake rate 0.012683 mL/sec/cm3 0.000605 7 1 S07-01
579 Th Hepatocellular mean transit time 280.818444 sec 15.086203 7 1 S07-01
580 Kbh Biliary tissue excretion rate 0.003561 mL/sec/cm3 0.000000 7 1 S07-01
581 Khe Hepatocellular tissue uptake rate 0.055144 mL/sec/cm3 0.000000 7 1 S07-01
582 kbh Biliary excretion rate 0.002742 mL/sec/cm3 0.000000 7 1 S07-01
583 E Liver extraction fraction 0.365485 0.000000 7 1 S07-01
584 Ktrans Hepatic plasma clearance 0.008048 mL/sec/cm3 0.000000 7 1 S07-01
585 H Hematocrit 0.418000 0.000000 7 1 S07-02
586 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-02
587 khe Hepatocellular uptake rate 0.022498 mL/sec/cm3 0.002039 7 1 S07-02
588 Th Hepatocellular mean transit time 289.856768 sec 28.949742 7 1 S07-02
589 Kbh Biliary tissue excretion rate 0.003450 mL/sec/cm3 0.000000 7 1 S07-02
590 Khe Hepatocellular tissue uptake rate 0.097817 mL/sec/cm3 0.000000 7 1 S07-02
591 kbh Biliary excretion rate 0.002656 mL/sec/cm3 0.000000 7 1 S07-02
592 E Liver extraction fraction 0.505379 0.000000 7 1 S07-02
593 Ktrans Hepatic plasma clearance 0.011128 mL/sec/cm3 0.000000 7 1 S07-02
594 H Hematocrit 0.418000 0.000000 7 1 S07-03
595 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-03
596 khe Hepatocellular uptake rate 0.021004 mL/sec/cm3 0.002048 7 1 S07-03
597 Th Hepatocellular mean transit time 278.527976 sec 29.888574 7 1 S07-03
598 Kbh Biliary tissue excretion rate 0.003590 mL/sec/cm3 0.000000 7 1 S07-03
599 Khe Hepatocellular tissue uptake rate 0.091322 mL/sec/cm3 0.000000 7 1 S07-03
600 kbh Biliary excretion rate 0.002765 mL/sec/cm3 0.000000 7 1 S07-03
601 E Liver extraction fraction 0.488205 0.000000 7 1 S07-03
602 Ktrans Hepatic plasma clearance 0.010750 mL/sec/cm3 0.000000 7 1 S07-03
603 H Hematocrit 0.418000 0.000000 7 1 S07-04
604 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-04
605 khe Hepatocellular uptake rate 0.013532 mL/sec/cm3 0.000956 7 1 S07-04
606 Th Hepatocellular mean transit time 292.655037 sec 23.359213 7 1 S07-04
607 Kbh Biliary tissue excretion rate 0.003417 mL/sec/cm3 0.000000 7 1 S07-04
608 Khe Hepatocellular tissue uptake rate 0.058834 mL/sec/cm3 0.000000 7 1 S07-04
609 kbh Biliary excretion rate 0.002631 mL/sec/cm3 0.000000 7 1 S07-04
610 E Liver extraction fraction 0.380634 0.000000 7 1 S07-04
611 Ktrans Hepatic plasma clearance 0.008381 mL/sec/cm3 0.000000 7 1 S07-04
612 H Hematocrit 0.418000 0.000000 7 1 S07-05
613 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-05
614 khe Hepatocellular uptake rate 0.021344 mL/sec/cm3 0.002382 7 1 S07-05
615 Th Hepatocellular mean transit time 214.314612 sec 25.739821 7 1 S07-05
616 Kbh Biliary tissue excretion rate 0.004666 mL/sec/cm3 0.000000 7 1 S07-05
617 Khe Hepatocellular tissue uptake rate 0.092802 mL/sec/cm3 0.000000 7 1 S07-05
618 kbh Biliary excretion rate 0.003593 mL/sec/cm3 0.000000 7 1 S07-05
619 E Liver extraction fraction 0.492223 0.000000 7 1 S07-05
620 Ktrans Hepatic plasma clearance 0.010838 mL/sec/cm3 0.000000 7 1 S07-05
621 H Hematocrit 0.418000 0.000000 7 1 S07-06
622 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-06
623 khe Hepatocellular uptake rate 0.023153 mL/sec/cm3 0.002535 7 1 S07-06
624 Th Hepatocellular mean transit time 254.391468 sec 30.205870 7 1 S07-06
625 Kbh Biliary tissue excretion rate 0.003931 mL/sec/cm3 0.000000 7 1 S07-06
626 Khe Hepatocellular tissue uptake rate 0.100663 mL/sec/cm3 0.000000 7 1 S07-06
627 kbh Biliary excretion rate 0.003027 mL/sec/cm3 0.000000 7 1 S07-06
628 E Liver extraction fraction 0.512547 0.000000 7 1 S07-06
629 Ktrans Hepatic plasma clearance 0.011286 mL/sec/cm3 0.000000 7 1 S07-06
630 H Hematocrit 0.418000 0.000000 8 1 S08-01
631 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-01
632 khe Hepatocellular uptake rate 0.029672 mL/sec/cm3 0.001981 8 1 S08-01
633 Th Hepatocellular mean transit time 405.004251 sec 31.330233 8 1 S08-01
634 Kbh Biliary tissue excretion rate 0.002469 mL/sec/cm3 0.000000 8 1 S08-01
635 Khe Hepatocellular tissue uptake rate 0.129007 mL/sec/cm3 0.000000 8 1 S08-01
636 kbh Biliary excretion rate 0.001901 mL/sec/cm3 0.000000 8 1 S08-01
637 E Liver extraction fraction 0.574023 0.000000 8 1 S08-01
638 Ktrans Hepatic plasma clearance 0.012639 mL/sec/cm3 0.000000 8 1 S08-01
639 H Hematocrit 0.418000 0.000000 8 1 S08-02
640 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-02
641 khe Hepatocellular uptake rate 0.028285 mL/sec/cm3 0.002532 8 1 S08-02
642 Th Hepatocellular mean transit time 266.518224 sec 25.642295 8 1 S08-02
643 Kbh Biliary tissue excretion rate 0.003752 mL/sec/cm3 0.000000 8 1 S08-02
644 Khe Hepatocellular tissue uptake rate 0.122977 mL/sec/cm3 0.000000 8 1 S08-02
645 kbh Biliary excretion rate 0.002889 mL/sec/cm3 0.000000 8 1 S08-02
646 E Liver extraction fraction 0.562279 0.000000 8 1 S08-02
647 Ktrans Hepatic plasma clearance 0.012381 mL/sec/cm3 0.000000 8 1 S08-02
648 H Hematocrit 0.418000 0.000000 8 1 S08-03
649 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-03
650 khe Hepatocellular uptake rate 0.020065 mL/sec/cm3 0.001380 8 1 S08-03
651 Th Hepatocellular mean transit time 379.280945 sec 30.381067 8 1 S08-03
652 Kbh Biliary tissue excretion rate 0.002637 mL/sec/cm3 0.000000 8 1 S08-03
653 Khe Hepatocellular tissue uptake rate 0.087241 mL/sec/cm3 0.000000 8 1 S08-03
654 kbh Biliary excretion rate 0.002030 mL/sec/cm3 0.000000 8 1 S08-03
655 E Liver extraction fraction 0.476791 0.000000 8 1 S08-03
656 Ktrans Hepatic plasma clearance 0.010498 mL/sec/cm3 0.000000 8 1 S08-03
657 H Hematocrit 0.418000 0.000000 8 1 S08-04
658 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-04
659 khe Hepatocellular uptake rate 0.019140 mL/sec/cm3 0.001184 8 1 S08-04
660 Th Hepatocellular mean transit time 430.119180 sec 32.192971 8 1 S08-04
661 Kbh Biliary tissue excretion rate 0.002325 mL/sec/cm3 0.000000 8 1 S08-04
662 Khe Hepatocellular tissue uptake rate 0.083217 mL/sec/cm3 0.000000 8 1 S08-04
663 kbh Biliary excretion rate 0.001790 mL/sec/cm3 0.000000 8 1 S08-04
664 E Liver extraction fraction 0.465024 0.000000 8 1 S08-04
665 Ktrans Hepatic plasma clearance 0.010239 mL/sec/cm3 0.000000 8 1 S08-04
666 H Hematocrit 0.418000 0.000000 8 1 S08-05
667 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-05
668 khe Hepatocellular uptake rate 0.026410 mL/sec/cm3 0.002126 8 1 S08-05
669 Th Hepatocellular mean transit time 259.353153 sec 22.470592 8 1 S08-05
670 Kbh Biliary tissue excretion rate 0.003856 mL/sec/cm3 0.000000 8 1 S08-05
671 Khe Hepatocellular tissue uptake rate 0.114828 mL/sec/cm3 0.000000 8 1 S08-05
672 kbh Biliary excretion rate 0.002969 mL/sec/cm3 0.000000 8 1 S08-05
673 E Liver extraction fraction 0.545338 0.000000 8 1 S08-05
674 Ktrans Hepatic plasma clearance 0.012008 mL/sec/cm3 0.000000 8 1 S08-05
675 H Hematocrit 0.418000 0.000000 8 1 S08-06
676 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-06
677 khe Hepatocellular uptake rate 0.025848 mL/sec/cm3 0.002068 8 1 S08-06
678 Th Hepatocellular mean transit time 292.292001 sec 25.549667 8 1 S08-06
679 Kbh Biliary tissue excretion rate 0.003421 mL/sec/cm3 0.000000 8 1 S08-06
680 Khe Hepatocellular tissue uptake rate 0.112383 mL/sec/cm3 0.000000 8 1 S08-06
681 kbh Biliary excretion rate 0.002634 mL/sec/cm3 0.000000 8 1 S08-06
682 E Liver extraction fraction 0.539997 0.000000 8 1 S08-06
683 Ktrans Hepatic plasma clearance 0.011890 mL/sec/cm3 0.000000 8 1 S08-06
684 H Hematocrit 0.418000 0.000000 9 1 S09-01
685 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-01
686 khe Hepatocellular uptake rate 0.019960 mL/sec/cm3 0.000712 9 1 S09-01
687 Th Hepatocellular mean transit time 374.868102 sec 15.694085 9 1 S09-01
688 Kbh Biliary tissue excretion rate 0.002668 mL/sec/cm3 0.000000 9 1 S09-01
689 Khe Hepatocellular tissue uptake rate 0.086781 mL/sec/cm3 0.000000 9 1 S09-01
690 kbh Biliary excretion rate 0.002054 mL/sec/cm3 0.000000 9 1 S09-01
691 E Liver extraction fraction 0.475470 0.000000 9 1 S09-01
692 Ktrans Hepatic plasma clearance 0.010469 mL/sec/cm3 0.000000 9 1 S09-01
693 H Hematocrit 0.418000 0.000000 9 1 S09-02
694 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-02
695 khe Hepatocellular uptake rate 0.017014 mL/sec/cm3 0.001283 9 1 S09-02
696 Th Hepatocellular mean transit time 232.394677 sec 19.287626 9 1 S09-02
697 Kbh Biliary tissue excretion rate 0.004303 mL/sec/cm3 0.000000 9 1 S09-02
698 Khe Hepatocellular tissue uptake rate 0.073975 mL/sec/cm3 0.000000 9 1 S09-02
699 kbh Biliary excretion rate 0.003313 mL/sec/cm3 0.000000 9 1 S09-02
700 E Liver extraction fraction 0.435892 0.000000 9 1 S09-02
701 Ktrans Hepatic plasma clearance 0.009598 mL/sec/cm3 0.000000 9 1 S09-02
702 H Hematocrit 0.418000 0.000000 9 1 S09-03
703 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-03
704 khe Hepatocellular uptake rate 0.028221 mL/sec/cm3 0.002239 9 1 S09-03
705 Th Hepatocellular mean transit time 298.016000 sec 26.121908 9 1 S09-03
706 Kbh Biliary tissue excretion rate 0.003356 mL/sec/cm3 0.000000 9 1 S09-03
707 Khe Hepatocellular tissue uptake rate 0.122699 mL/sec/cm3 0.000000 9 1 S09-03
708 kbh Biliary excretion rate 0.002584 mL/sec/cm3 0.000000 9 1 S09-03
709 E Liver extraction fraction 0.561721 0.000000 9 1 S09-03
710 Ktrans Hepatic plasma clearance 0.012369 mL/sec/cm3 0.000000 9 1 S09-03
711 H Hematocrit 0.418000 0.000000 9 1 S09-04
712 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-04
713 khe Hepatocellular uptake rate 0.031739 mL/sec/cm3 0.002274 9 1 S09-04
714 Th Hepatocellular mean transit time 277.181483 sec 21.584015 9 1 S09-04
715 Kbh Biliary tissue excretion rate 0.003608 mL/sec/cm3 0.000000 9 1 S09-04
716 Khe Hepatocellular tissue uptake rate 0.137997 mL/sec/cm3 0.000000 9 1 S09-04
717 kbh Biliary excretion rate 0.002778 mL/sec/cm3 0.000000 9 1 S09-04
718 E Liver extraction fraction 0.590408 0.000000 9 1 S09-04
719 Ktrans Hepatic plasma clearance 0.013000 mL/sec/cm3 0.000000 9 1 S09-04
720 H Hematocrit 0.418000 0.000000 10 1 S10-01
721 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-01
722 khe Hepatocellular uptake rate 0.032535 mL/sec/cm3 0.002453 10 1 S10-01
723 Th Hepatocellular mean transit time 204.527816 sec 16.360118 10 1 S10-01
724 Kbh Biliary tissue excretion rate 0.004889 mL/sec/cm3 0.000000 10 1 S10-01
725 Khe Hepatocellular tissue uptake rate 0.141456 mL/sec/cm3 0.000000 10 1 S10-01
726 kbh Biliary excretion rate 0.003765 mL/sec/cm3 0.000000 10 1 S10-01
727 E Liver extraction fraction 0.596381 0.000000 10 1 S10-01
728 Ktrans Hepatic plasma clearance 0.013132 mL/sec/cm3 0.000000 10 1 S10-01
729 H Hematocrit 0.418000 0.000000 10 1 S10-02
730 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-02
731 khe Hepatocellular uptake rate 0.025874 mL/sec/cm3 0.001773 10 1 S10-02
732 Th Hepatocellular mean transit time 261.575446 sec 19.579156 10 1 S10-02
733 Kbh Biliary tissue excretion rate 0.003823 mL/sec/cm3 0.000000 10 1 S10-02
734 Khe Hepatocellular tissue uptake rate 0.112497 mL/sec/cm3 0.000000 10 1 S10-02
735 kbh Biliary excretion rate 0.002944 mL/sec/cm3 0.000000 10 1 S10-02
736 E Liver extraction fraction 0.540249 0.000000 10 1 S10-02
737 Ktrans Hepatic plasma clearance 0.011896 mL/sec/cm3 0.000000 10 1 S10-02
738 H Hematocrit 0.418000 0.000000 10 1 S10-03
739 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-03
740 khe Hepatocellular uptake rate 0.036652 mL/sec/cm3 0.002989 10 1 S10-03
741 Th Hepatocellular mean transit time 192.444917 sec 16.496094 10 1 S10-03
742 Kbh Biliary tissue excretion rate 0.005196 mL/sec/cm3 0.000000 10 1 S10-03
743 Khe Hepatocellular tissue uptake rate 0.159357 mL/sec/cm3 0.000000 10 1 S10-03
744 kbh Biliary excretion rate 0.004001 mL/sec/cm3 0.000000 10 1 S10-03
745 E Liver extraction fraction 0.624705 0.000000 10 1 S10-03
746 Ktrans Hepatic plasma clearance 0.013755 mL/sec/cm3 0.000000 10 1 S10-03
747 H Hematocrit 0.418000 0.000000 10 1 S10-04
748 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-04
749 khe Hepatocellular uptake rate 0.034455 mL/sec/cm3 0.003410 10 1 S10-04
750 Th Hepatocellular mean transit time 221.622695 sec 23.277153 10 1 S10-04
751 Kbh Biliary tissue excretion rate 0.004512 mL/sec/cm3 0.000000 10 1 S10-04
752 Khe Hepatocellular tissue uptake rate 0.149806 mL/sec/cm3 0.000000 10 1 S10-04
753 kbh Biliary excretion rate 0.003474 mL/sec/cm3 0.000000 10 1 S10-04
754 E Liver extraction fraction 0.610107 0.000000 10 1 S10-04
755 Ktrans Hepatic plasma clearance 0.013434 mL/sec/cm3 0.000000 10 1 S10-04
756 H Hematocrit 0.418000 0.000000 10 1 S10-05
757 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-05
758 khe Hepatocellular uptake rate 0.032610 mL/sec/cm3 0.002460 10 1 S10-05
759 Th Hepatocellular mean transit time 203.726712 sec 16.301197 10 1 S10-05
760 Kbh Biliary tissue excretion rate 0.004909 mL/sec/cm3 0.000000 10 1 S10-05
761 Khe Hepatocellular tissue uptake rate 0.141781 mL/sec/cm3 0.000000 10 1 S10-05
762 kbh Biliary excretion rate 0.003780 mL/sec/cm3 0.000000 10 1 S10-05
763 E Liver extraction fraction 0.596933 0.000000 10 1 S10-05
764 Ktrans Hepatic plasma clearance 0.013144 mL/sec/cm3 0.000000 10 1 S10-05
765 H Hematocrit 0.418000 0.000000 10 1 S10-06
766 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-06
767 khe Hepatocellular uptake rate 0.039860 mL/sec/cm3 0.002835 10 1 S10-06
768 Th Hepatocellular mean transit time 225.726632 sec 16.897259 10 1 S10-06
769 Kbh Biliary tissue excretion rate 0.004430 mL/sec/cm3 0.000000 10 1 S10-06
770 Khe Hepatocellular tissue uptake rate 0.173305 mL/sec/cm3 0.000000 10 1 S10-06
771 kbh Biliary excretion rate 0.003411 mL/sec/cm3 0.000000 10 1 S10-06
772 E Liver extraction fraction 0.644162 0.000000 10 1 S10-06
773 Ktrans Hepatic plasma clearance 0.014184 mL/sec/cm3 0.000000 10 1 S10-06
774 H Hematocrit 0.418000 0.000000 11 1 S11-01
775 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-01
776 khe Hepatocellular uptake rate 0.013910 mL/sec/cm3 0.000883 11 1 S11-01
777 Th Hepatocellular mean transit time 228.002321 sec 16.022045 11 1 S11-01
778 Kbh Biliary tissue excretion rate 0.004386 mL/sec/cm3 0.000000 11 1 S11-01
779 Khe Hepatocellular tissue uptake rate 0.060480 mL/sec/cm3 0.000000 11 1 S11-01
780 kbh Biliary excretion rate 0.003377 mL/sec/cm3 0.000000 11 1 S11-01
781 E Liver extraction fraction 0.387160 0.000000 11 1 S11-01
782 Ktrans Hepatic plasma clearance 0.008525 mL/sec/cm3 0.000000 11 1 S11-01
783 H Hematocrit 0.418000 0.000000 11 1 S11-02
784 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-02
785 khe Hepatocellular uptake rate 0.028271 mL/sec/cm3 0.001964 11 1 S11-02
786 Th Hepatocellular mean transit time 269.927474 sec 20.456646 11 1 S11-02
787 Kbh Biliary tissue excretion rate 0.003705 mL/sec/cm3 0.000000 11 1 S11-02
788 Khe Hepatocellular tissue uptake rate 0.122916 mL/sec/cm3 0.000000 11 1 S11-02
789 kbh Biliary excretion rate 0.002853 mL/sec/cm3 0.000000 11 1 S11-02
790 E Liver extraction fraction 0.562157 0.000000 11 1 S11-02
791 Ktrans Hepatic plasma clearance 0.012378 mL/sec/cm3 0.000000 11 1 S11-02
792 H Hematocrit 0.418000 0.000000 11 1 S11-03
793 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-03
794 khe Hepatocellular uptake rate 0.029927 mL/sec/cm3 0.002653 11 1 S11-03
795 Th Hepatocellular mean transit time 219.983453 sec 20.856391 11 1 S11-03
796 Kbh Biliary tissue excretion rate 0.004546 mL/sec/cm3 0.000000 11 1 S11-03
797 Khe Hepatocellular tissue uptake rate 0.130119 mL/sec/cm3 0.000000 11 1 S11-03
798 kbh Biliary excretion rate 0.003500 mL/sec/cm3 0.000000 11 1 S11-03
799 E Liver extraction fraction 0.576120 0.000000 11 1 S11-03
800 Ktrans Hepatic plasma clearance 0.012686 mL/sec/cm3 0.000000 11 1 S11-03
801 H Hematocrit 0.418000 0.000000 11 1 S11-04
802 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-04
803 khe Hepatocellular uptake rate 0.028979 mL/sec/cm3 0.002284 11 1 S11-04
804 Th Hepatocellular mean transit time 235.280521 sec 19.953238 11 1 S11-04
805 Kbh Biliary tissue excretion rate 0.004250 mL/sec/cm3 0.000000 11 1 S11-04
806 Khe Hepatocellular tissue uptake rate 0.125996 mL/sec/cm3 0.000000 11 1 S11-04
807 kbh Biliary excretion rate 0.003273 mL/sec/cm3 0.000000 11 1 S11-04
808 E Liver extraction fraction 0.568238 0.000000 11 1 S11-04
809 Ktrans Hepatic plasma clearance 0.012512 mL/sec/cm3 0.000000 11 1 S11-04
810 H Hematocrit 0.418000 0.000000 11 1 S11-05
811 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-05
812 khe Hepatocellular uptake rate 0.023743 mL/sec/cm3 0.001678 11 1 S11-05
813 Th Hepatocellular mean transit time 314.105499 sec 24.947777 11 1 S11-05
814 Kbh Biliary tissue excretion rate 0.003184 mL/sec/cm3 0.000000 11 1 S11-05
815 Khe Hepatocellular tissue uptake rate 0.103230 mL/sec/cm3 0.000000 11 1 S11-05
816 kbh Biliary excretion rate 0.002451 mL/sec/cm3 0.000000 11 1 S11-05
817 E Liver extraction fraction 0.518835 0.000000 11 1 S11-05
818 Ktrans Hepatic plasma clearance 0.011424 mL/sec/cm3 0.000000 11 1 S11-05
819 H Hematocrit 0.418000 0.000000 11 1 S11-06
820 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-06
821 khe Hepatocellular uptake rate 0.029244 mL/sec/cm3 0.002005 11 1 S11-06
822 Th Hepatocellular mean transit time 265.109625 sec 19.750232 11 1 S11-06
823 Kbh Biliary tissue excretion rate 0.003772 mL/sec/cm3 0.000000 11 1 S11-06
824 Khe Hepatocellular tissue uptake rate 0.127146 mL/sec/cm3 0.000000 11 1 S11-06
825 kbh Biliary excretion rate 0.002904 mL/sec/cm3 0.000000 11 1 S11-06
826 E Liver extraction fraction 0.570467 0.000000 11 1 S11-06
827 Ktrans Hepatic plasma clearance 0.012561 mL/sec/cm3 0.000000 11 1 S11-06
828 H Hematocrit 0.418000 0.000000 12 1 S12-01
829 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-01
830 khe Hepatocellular uptake rate 0.030382 mL/sec/cm3 0.001993 12 1 S12-01
831 Th Hepatocellular mean transit time 323.452982 sec 23.292382 12 1 S12-01
832 Kbh Biliary tissue excretion rate 0.003092 mL/sec/cm3 0.000000 12 1 S12-01
833 Khe Hepatocellular tissue uptake rate 0.132094 mL/sec/cm3 0.000000 12 1 S12-01
834 kbh Biliary excretion rate 0.002381 mL/sec/cm3 0.000000 12 1 S12-01
835 E Liver extraction fraction 0.579795 0.000000 12 1 S12-01
836 Ktrans Hepatic plasma clearance 0.012766 mL/sec/cm3 0.000000 12 1 S12-01
837 H Hematocrit 0.418000 0.000000 12 1 S12-02
838 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-02
839 khe Hepatocellular uptake rate 0.027904 mL/sec/cm3 0.001966 12 1 S12-02
840 Th Hepatocellular mean transit time 259.614962 sec 19.620797 12 1 S12-02
841 Kbh Biliary tissue excretion rate 0.003852 mL/sec/cm3 0.000000 12 1 S12-02
842 Khe Hepatocellular tissue uptake rate 0.121321 mL/sec/cm3 0.000000 12 1 S12-02
843 kbh Biliary excretion rate 0.002966 mL/sec/cm3 0.000000 12 1 S12-02
844 E Liver extraction fraction 0.558940 0.000000 12 1 S12-02
845 Ktrans Hepatic plasma clearance 0.012307 mL/sec/cm3 0.000000 12 1 S12-02
846 H Hematocrit 0.418000 0.000000 12 1 S12-03
847 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-03
848 khe Hepatocellular uptake rate 0.031209 mL/sec/cm3 0.002123 12 1 S12-03
849 Th Hepatocellular mean transit time 259.228305 sec 18.775624 12 1 S12-03
850 Kbh Biliary tissue excretion rate 0.003858 mL/sec/cm3 0.000000 12 1 S12-03
851 Khe Hepatocellular tissue uptake rate 0.135692 mL/sec/cm3 0.000000 12 1 S12-03
852 kbh Biliary excretion rate 0.002970 mL/sec/cm3 0.000000 12 1 S12-03
853 E Liver extraction fraction 0.586328 0.000000 12 1 S12-03
854 Ktrans Hepatic plasma clearance 0.012910 mL/sec/cm3 0.000000 12 1 S12-03
855 H Hematocrit 0.418000 0.000000 12 1 S12-04
856 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-04
857 khe Hepatocellular uptake rate 0.028901 mL/sec/cm3 0.001864 12 1 S12-04
858 Th Hepatocellular mean transit time 267.022788 sec 18.488555 12 1 S12-04
859 Kbh Biliary tissue excretion rate 0.003745 mL/sec/cm3 0.000000 12 1 S12-04
860 Khe Hepatocellular tissue uptake rate 0.125658 mL/sec/cm3 0.000000 12 1 S12-04
861 kbh Biliary excretion rate 0.002884 mL/sec/cm3 0.000000 12 1 S12-04
862 E Liver extraction fraction 0.567579 0.000000 12 1 S12-04
863 Ktrans Hepatic plasma clearance 0.012498 mL/sec/cm3 0.000000 12 1 S12-04
864 H Hematocrit 0.418000 0.000000 13 1 S13-01
865 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-01
866 khe Hepatocellular uptake rate 0.019700 mL/sec/cm3 0.002472 13 1 S13-01
867 Th Hepatocellular mean transit time 153.711636 sec 20.567217 13 1 S13-01
868 Kbh Biliary tissue excretion rate 0.006506 mL/sec/cm3 0.000000 13 1 S13-01
869 Khe Hepatocellular tissue uptake rate 0.085651 mL/sec/cm3 0.000000 13 1 S13-01
870 kbh Biliary excretion rate 0.005009 mL/sec/cm3 0.000000 13 1 S13-01
871 E Liver extraction fraction 0.472203 0.000000 13 1 S13-01
872 Ktrans Hepatic plasma clearance 0.010397 mL/sec/cm3 0.000000 13 1 S13-01
873 H Hematocrit 0.418000 0.000000 13 2 S13-01
874 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-01
875 khe Hepatocellular uptake rate 0.024712 mL/sec/cm3 0.001605 13 2 S13-01
876 Th Hepatocellular mean transit time 245.211257 sec 17.339565 13 2 S13-01
877 Kbh Biliary tissue excretion rate 0.004078 mL/sec/cm3 0.000000 13 2 S13-01
878 Khe Hepatocellular tissue uptake rate 0.107443 mL/sec/cm3 0.000000 13 2 S13-01
879 kbh Biliary excretion rate 0.003140 mL/sec/cm3 0.000000 13 2 S13-01
880 E Liver extraction fraction 0.528812 0.000000 13 2 S13-01
881 Ktrans Hepatic plasma clearance 0.011644 mL/sec/cm3 0.000000 13 2 S13-01
882 H Hematocrit 0.418000 0.000000 13 1 S13-02
883 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-02
884 khe Hepatocellular uptake rate 0.027132 mL/sec/cm3 0.002481 13 1 S13-02
885 Th Hepatocellular mean transit time 185.363576 sec 17.873643 13 1 S13-02
886 Kbh Biliary tissue excretion rate 0.005395 mL/sec/cm3 0.000000 13 1 S13-02
887 Khe Hepatocellular tissue uptake rate 0.117966 mL/sec/cm3 0.000000 13 1 S13-02
888 kbh Biliary excretion rate 0.004154 mL/sec/cm3 0.000000 13 1 S13-02
889 E Liver extraction fraction 0.552014 0.000000 13 1 S13-02
890 Ktrans Hepatic plasma clearance 0.012155 mL/sec/cm3 0.000000 13 1 S13-02
891 H Hematocrit 0.418000 0.000000 13 2 S13-02
892 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-02
893 khe Hepatocellular uptake rate 0.027491 mL/sec/cm3 0.001954 13 2 S13-02
894 Th Hepatocellular mean transit time 238.054894 sec 18.275959 13 2 S13-02
895 Kbh Biliary tissue excretion rate 0.004201 mL/sec/cm3 0.000000 13 2 S13-02
896 Khe Hepatocellular tissue uptake rate 0.119526 mL/sec/cm3 0.000000 13 2 S13-02
897 kbh Biliary excretion rate 0.003235 mL/sec/cm3 0.000000 13 2 S13-02
898 E Liver extraction fraction 0.555262 0.000000 13 2 S13-02
899 Ktrans Hepatic plasma clearance 0.012226 mL/sec/cm3 0.000000 13 2 S13-02
900 H Hematocrit 0.418000 0.000000 13 1 S13-03
901 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-03
902 khe Hepatocellular uptake rate 0.024895 mL/sec/cm3 0.002588 13 1 S13-03
903 Th Hepatocellular mean transit time 212.113469 sec 23.485823 13 1 S13-03
904 Kbh Biliary tissue excretion rate 0.004714 mL/sec/cm3 0.000000 13 1 S13-03
905 Khe Hepatocellular tissue uptake rate 0.108241 mL/sec/cm3 0.000000 13 1 S13-03
906 kbh Biliary excretion rate 0.003630 mL/sec/cm3 0.000000 13 1 S13-03
907 E Liver extraction fraction 0.530656 0.000000 13 1 S13-03
908 Ktrans Hepatic plasma clearance 0.011685 mL/sec/cm3 0.000000 13 1 S13-03
909 H Hematocrit 0.418000 0.000000 13 2 S13-03
910 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-03
911 khe Hepatocellular uptake rate 0.022076 mL/sec/cm3 0.001822 13 2 S13-03
912 Th Hepatocellular mean transit time 227.337667 sec 20.418991 13 2 S13-03
913 Kbh Biliary tissue excretion rate 0.004399 mL/sec/cm3 0.000000 13 2 S13-03
914 Khe Hepatocellular tissue uptake rate 0.095981 mL/sec/cm3 0.000000 13 2 S13-03
915 kbh Biliary excretion rate 0.003387 mL/sec/cm3 0.000000 13 2 S13-03
916 E Liver extraction fraction 0.500643 0.000000 13 2 S13-03
917 Ktrans Hepatic plasma clearance 0.011024 mL/sec/cm3 0.000000 13 2 S13-03
918 H Hematocrit 0.418000 0.000000 13 1 S13-04
919 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-04
920 khe Hepatocellular uptake rate 0.037487 mL/sec/cm3 0.002924 13 1 S13-04
921 Th Hepatocellular mean transit time 254.710084 sec 21.177787 13 1 S13-04
922 Kbh Biliary tissue excretion rate 0.003926 mL/sec/cm3 0.000000 13 1 S13-04
923 Khe Hepatocellular tissue uptake rate 0.162987 mL/sec/cm3 0.000000 13 1 S13-04
924 kbh Biliary excretion rate 0.003023 mL/sec/cm3 0.000000 13 1 S13-04
925 E Liver extraction fraction 0.629970 0.000000 13 1 S13-04
926 Ktrans Hepatic plasma clearance 0.013871 mL/sec/cm3 0.000000 13 1 S13-04
927 H Hematocrit 0.418000 0.000000 13 2 S13-04
928 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-04
929 khe Hepatocellular uptake rate 0.032979 mL/sec/cm3 0.003123 13 2 S13-04
930 Th Hepatocellular mean transit time 238.990758 sec 23.840564 13 2 S13-04
931 Kbh Biliary tissue excretion rate 0.004184 mL/sec/cm3 0.000000 13 2 S13-04
932 Khe Hepatocellular tissue uptake rate 0.143387 mL/sec/cm3 0.000000 13 2 S13-04
933 kbh Biliary excretion rate 0.003222 mL/sec/cm3 0.000000 13 2 S13-04
934 E Liver extraction fraction 0.599639 0.000000 13 2 S13-04
935 Ktrans Hepatic plasma clearance 0.013203 mL/sec/cm3 0.000000 13 2 S13-04
936 H Hematocrit 0.418000 0.000000 13 1 S13-05
937 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-05
938 khe Hepatocellular uptake rate 0.039701 mL/sec/cm3 0.004912 13 1 S13-05
939 Th Hepatocellular mean transit time 189.604715 sec 24.516975 13 1 S13-05
940 Kbh Biliary tissue excretion rate 0.005274 mL/sec/cm3 0.000000 13 1 S13-05
941 Khe Hepatocellular tissue uptake rate 0.172615 mL/sec/cm3 0.000000 13 1 S13-05
942 kbh Biliary excretion rate 0.004061 mL/sec/cm3 0.000000 13 1 S13-05
943 E Liver extraction fraction 0.643246 0.000000 13 1 S13-05
944 Ktrans Hepatic plasma clearance 0.014164 mL/sec/cm3 0.000000 13 1 S13-05
945 H Hematocrit 0.418000 0.000000 13 2 S13-05
946 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-05
947 khe Hepatocellular uptake rate 0.029427 mL/sec/cm3 0.003025 13 2 S13-05
948 Th Hepatocellular mean transit time 178.498551 sec 19.238985 13 2 S13-05
949 Kbh Biliary tissue excretion rate 0.005602 mL/sec/cm3 0.000000 13 2 S13-05
950 Khe Hepatocellular tissue uptake rate 0.127945 mL/sec/cm3 0.000000 13 2 S13-05
951 kbh Biliary excretion rate 0.004314 mL/sec/cm3 0.000000 13 2 S13-05
952 E Liver extraction fraction 0.572002 0.000000 13 2 S13-05
953 Ktrans Hepatic plasma clearance 0.012595 mL/sec/cm3 0.000000 13 2 S13-05
954 H Hematocrit 0.418000 0.000000 13 1 S13-06
955 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-06
956 khe Hepatocellular uptake rate 0.037005 mL/sec/cm3 0.003320 13 1 S13-06
957 Th Hepatocellular mean transit time 204.412021 sec 19.303916 13 1 S13-06
958 Kbh Biliary tissue excretion rate 0.004892 mL/sec/cm3 0.000000 13 1 S13-06
959 Khe Hepatocellular tissue uptake rate 0.160893 mL/sec/cm3 0.000000 13 1 S13-06
960 kbh Biliary excretion rate 0.003767 mL/sec/cm3 0.000000 13 1 S13-06
961 E Liver extraction fraction 0.626951 0.000000 13 1 S13-06
962 Ktrans Hepatic plasma clearance 0.013805 mL/sec/cm3 0.000000 13 1 S13-06
963 H Hematocrit 0.418000 0.000000 13 2 S13-06
964 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-06
965 khe Hepatocellular uptake rate 0.027897 mL/sec/cm3 0.001381 13 2 S13-06
966 Th Hepatocellular mean transit time 210.157352 sec 11.006029 13 2 S13-06
967 Kbh Biliary tissue excretion rate 0.004758 mL/sec/cm3 0.000000 13 2 S13-06
968 Khe Hepatocellular tissue uptake rate 0.121293 mL/sec/cm3 0.000000 13 2 S13-06
969 kbh Biliary excretion rate 0.003664 mL/sec/cm3 0.000000 13 2 S13-06
970 E Liver extraction fraction 0.558882 0.000000 13 2 S13-06
971 Ktrans Hepatic plasma clearance 0.012306 mL/sec/cm3 0.000000 13 2 S13-06
Plot individual results#
Now let’s calculate the average biomarker values per substudy for saline data only. For this exercise, let’s specify khe and kbh as the biomarker parameters that we are interested in. For each biomarker, we can plot the avergae biomarker values along with their 95% confidence intervals for each study group. We can also calculate an average ‘benchmark’ value across all study groups for each biomarker, and overlay these on the graphs to see whether the observed values lie within these ranges. red lines indicate the average benchmark value, while blue represents the upper and lower limits of the 95% confidence intervals (CIs) associated with these benchmarks.
# Customise plot settings
plt.rcParams['savefig.dpi'] = 300
plt.rcParams["axes.labelsize"] = 50
plt.rcParams["axes.titlesize"] = 50
plt.rcParams["axes.labelweight"] = 'bold'
plt.rcParams["axes.titleweight"] = 'bold'
plt.rcParams["font.weight"] = 'bold'
plt.rc('axes', linewidth=2)
plt.rc('xtick', labelsize=40)
plt.rc('ytick', labelsize=40)
plt.rcParams["lines.linewidth"] = 4
plt.rcParams['lines.markersize'] = 12
# Create list of biomarkers (parameters) of interest
params = ['khe', 'kbh']
# Extract data of interest, i.e., visit 1 data for parameters of interest
visitOneData = results.query('parameter in @params and visit==1')
# Get statistical summaries per parameter and study group
stat_summary = (visitOneData
.groupby(['parameter', 'study'])['value']
.agg(['mean']))
# Calculate benchmark values per parameter by averaging all study group averages
benchmarks = (stat_summary
.groupby(['parameter'])['mean']
.agg(['mean', 'sem']))
# Calculate the 95% confidence intervals for each parameter benchmark
benchmarks['CI95'] = (benchmarks['sem'].mul(1.96))
# Sort dataframes
visitOneData_sorted = visitOneData.sort_values(['parameter'], ascending=[False])
benchmarks_sorted = benchmarks.sort_values(['parameter'], ascending=[False])
# Plot distributions across all study groups per biomarker of interest
g = sns.catplot(data=visitOneData_sorted,
x='study',
y='value',
col='parameter',
kind='point',
capsize=0.2,
sharey=False,
linestyle='none',
height=14,
aspect=1.2,
color='k',
errorbar=('ci', 95))
g.set_titles("") # set custom subplot titles
# Set limits for y-axes
g.axes[0, 0].set(ylim=([0, 0.05]))
g.axes[0, 1].set(ylim=([0, 0.006]))
ylabels = ['$k_{he}$', '$k_{bh}$'] # define labels for y-axis
# Assign values from benchmarks dataframe to be
# used as horizontal lines to overlay on plots
means = benchmarks_sorted['mean']
lower_cis = means - benchmarks_sorted['CI95']
upper_cis = means + benchmarks_sorted['CI95']
# iterate through subplots to overlay y-labels and axis lines
for i in range(len(ylabels)):
g.axes[0, i].set_ylabel(f"{ylabels[i]} [mL/sec/cm3]")
g.axes[0, i].axhline(means.iloc[i], color='blue', ls=':')
g.axes[0, i].axhline(lower_cis.iloc[i], color='red', ls='--')
g.axes[0, i].axhline(upper_cis.iloc[i], color='red', ls='--')
plt.tight_layout()
plt.show()
# Choose the last image as a thumbnail for the gallery
# sphinx_gallery_thumbnail_number = -1
Total running time of the script: (0 minutes 27.947 seconds)