Note
Go to the end to download the full example code.
Preclinical - reproducibility of hepatocellular function#
This example illustrates the use of Liver for fitting of signals
measured in liver. The use case is provided by the liver work package of the
TRISTAN project which develops imaging
biomarkers for drug safety assessment. The data and analysis were first
published in Gunwhy et al. (2024).
The specific objective of the study was to to identify the main sources of variability in DCE-MRI biomarkers of hepatocellular function in rats. This was done by comparing data measured at different centres and field strengths, at different days in the same subjects, and over the course of several months in the same centre.
The study presented here measured gadoxetate uptake and excretion in healthy rats either scanned once with vehicle or twice with either vehicle or 10 mg/kg of rifampicin at follow-up. Studies were performed in preclinical MRI scanners at 3 different centers and 2 different field strengths. Results demonstrated significant differences between substudies for uptake and excretion. Within-subject differences were substantially smaller for excretion but less so for uptake. Rifampicin-induced inhibition was safely above the detection limits for both uptake and excretion. Most of the variability in individual data was accounted for by between-subject and between-centre variability, substantially more than the between-day variation. Significant differences in excretion were observed between field strengths at the same centre, between centres at the same field strength, and between repeat experiments over 2 months apart in the same centre.
Reference
Gunwhy ER, Hines CDG, Green C, Laitinen I, Tadimalla S, Hockings PD, Schütz G, Kenna JG, Sourbron S, Waterton JC. Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study. MAGMA. 2024 Aug;37(4):697-708. [DOI]
Setup#
Model definition#
In order to avoid some repetition in this script, we define a function that returns a trained model for a single dataset.
The model uses a standardized, population-average input function and fits for only 2 parameters, fixing all other free parameters to typical values for this rat model:
def tristan_rat(roi, par, **kwargs):
# High-resolution time points for prediction
t = np.arange(0, np.amax(roi['time'])+0.5, 0.5)
# Standard input function
ca = dc.aif_tristan_rat(t, BAT=par['BAT'], duration=par['duration'])
# Liver model with population input function
model = dc.Liver(
# Input parameters
t = t,
ca = ca,
# Acquisition parameters
field_strength = par['field_strength'],
TR = par['TR'],
FA = par['FA'],
n0 = par['n0'],
# Configure as in the TRISTAN-rat study
config = 'TRISTAN-rat',
)
return model.train(roi['time'], roi['liver'], **kwargs)
Check model fit#
Before running the full analysis on all cases, lets illustrate the results by fitting the baseline visit for the first subject. We use maximum verbosity to get some feedback about the iterations:
Iteration Total nfev Cost Cost reduction Step norm Optimality
0 1 1.1223e+02 2.78e+04
1 3 5.7756e+01 5.45e+01 4.50e+02 4.47e+03
2 5 4.8000e+01 9.76e+00 3.37e+02 2.26e+03
3 6 3.6639e+01 1.14e+01 5.84e+02 7.38e+03
4 7 1.8168e+01 1.85e+01 3.67e+01 7.55e+02
5 8 1.5501e+01 2.67e+00 1.23e+02 1.51e+03
6 9 1.3877e+01 1.62e+00 1.55e+00 2.54e+01
7 10 1.3876e+01 4.86e-04 1.43e-02 1.95e-02
`xtol` termination condition is satisfied.
Function evaluations 10, initial cost 1.1223e+02, final cost 1.3876e+01, first-order optimality 1.95e-02.
Plot the results to check that the model has fitted the data:
Print the measured model parameters and any derived parameters and check that standard deviations of measured parameters are small relative to the value, indicating that the parameters are measured reliably:
model.print_params(round_to=3)
--------------------------------
Free parameters with their stdev
--------------------------------
Hepatocellular uptake rate (khe): 0.023 (0.003) mL/sec/cm3
Hepatocellular mean transit time (Th): 266.901 (33.958) sec
----------------------------
Fixed and derived parameters
----------------------------
Hematocrit (H): 0.418
Liver extracellular volume fraction (ve): 0.23 mL/cm3
Biliary tissue excretion rate (Kbh): 0.004 mL/sec/cm3
Hepatocellular tissue uptake rate (Khe): 0.099 mL/sec/cm3
Biliary excretion rate (kbh): 0.003 mL/sec/cm3
Liver extraction fraction (E): 0.508
Hepatic plasma clearance (Ktrans): 0.011 mL/sec/cm3
Fit all data#
Now that we have illustrated an individual result in some detail, we proceed with fitting all the data. Results are stored in a dataframe in long format:
results = []
# Loop over all datasets
for subj in rois.keys():
for visit in rois[subj].keys():
roi = rois[subj][visit]
par = pars[subj][visit]
# Generate a trained model
model = tristan_rat(roi, par, xtol=1e-3)
# Export fitted parameters as lists
rows = model.export_params(type='list')
# Add study, visit and subject info
rows = [row + [par['study'], par['visit'], subj] for row in rows]
# Add to the list of all results
results += rows
# Combine all results into a single dataframe.
cols = ['parameter', 'name', 'value', 'unit', 'stdev', 'study',
'visit', 'subject']
results = pd.DataFrame(results, columns=cols)
# Print all results
print(results.to_string())
parameter name value unit stdev study visit subject
0 H Hematocrit 0.418000 0.000000 1 1 S01-01
1 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-01
2 khe Hepatocellular uptake rate 0.022701 mL/sec/cm3 0.002651 1 1 S01-01
3 Th Hepatocellular mean transit time 266.901064 sec 33.957856 1 1 S01-01
4 Kbh Biliary tissue excretion rate 0.003747 mL/sec/cm3 0.000000 1 1 S01-01
5 Khe Hepatocellular tissue uptake rate 0.098699 mL/sec/cm3 0.000000 1 1 S01-01
6 kbh Biliary excretion rate 0.002885 mL/sec/cm3 0.000000 1 1 S01-01
7 E Liver extraction fraction 0.507622 0.000000 1 1 S01-01
8 Ktrans Hepatic plasma clearance 0.011177 mL/sec/cm3 0.000000 1 1 S01-01
9 H Hematocrit 0.418000 0.000000 1 2 S01-01
10 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-01
11 khe Hepatocellular uptake rate 0.020918 mL/sec/cm3 0.003735 1 2 S01-01
12 Th Hepatocellular mean transit time 243.879773 sec 47.254760 1 2 S01-01
13 Kbh Biliary tissue excretion rate 0.004100 mL/sec/cm3 0.000000 1 2 S01-01
14 Khe Hepatocellular tissue uptake rate 0.090949 mL/sec/cm3 0.000000 1 2 S01-01
15 kbh Biliary excretion rate 0.003157 mL/sec/cm3 0.000000 1 2 S01-01
16 E Liver extraction fraction 0.487183 0.000000 1 2 S01-01
17 Ktrans Hepatic plasma clearance 0.010727 mL/sec/cm3 0.000000 1 2 S01-01
18 H Hematocrit 0.418000 0.000000 1 1 S01-02
19 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-02
20 khe Hepatocellular uptake rate 0.023369 mL/sec/cm3 0.002335 1 1 S01-02
21 Th Hepatocellular mean transit time 260.154158 sec 28.196566 1 1 S01-02
22 Kbh Biliary tissue excretion rate 0.003844 mL/sec/cm3 0.000000 1 1 S01-02
23 Khe Hepatocellular tissue uptake rate 0.101603 mL/sec/cm3 0.000000 1 1 S01-02
24 kbh Biliary excretion rate 0.002960 mL/sec/cm3 0.000000 1 1 S01-02
25 E Liver extraction fraction 0.514869 0.000000 1 1 S01-02
26 Ktrans Hepatic plasma clearance 0.011337 mL/sec/cm3 0.000000 1 1 S01-02
27 H Hematocrit 0.418000 0.000000 1 2 S01-02
28 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-02
29 khe Hepatocellular uptake rate 0.022508 mL/sec/cm3 0.002475 1 2 S01-02
30 Th Hepatocellular mean transit time 261.093933 sec 31.218844 1 2 S01-02
31 Kbh Biliary tissue excretion rate 0.003830 mL/sec/cm3 0.000000 1 2 S01-02
32 Khe Hepatocellular tissue uptake rate 0.097860 mL/sec/cm3 0.000000 1 2 S01-02
33 kbh Biliary excretion rate 0.002949 mL/sec/cm3 0.000000 1 2 S01-02
34 E Liver extraction fraction 0.505490 0.000000 1 2 S01-02
35 Ktrans Hepatic plasma clearance 0.011130 mL/sec/cm3 0.000000 1 2 S01-02
36 H Hematocrit 0.418000 0.000000 1 1 S01-03
37 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-03
38 khe Hepatocellular uptake rate 0.020732 mL/sec/cm3 0.001915 1 1 S01-03
39 Th Hepatocellular mean transit time 255.544433 sec 25.731754 1 1 S01-03
40 Kbh Biliary tissue excretion rate 0.003913 mL/sec/cm3 0.000000 1 1 S01-03
41 Khe Hepatocellular tissue uptake rate 0.090140 mL/sec/cm3 0.000000 1 1 S01-03
42 kbh Biliary excretion rate 0.003013 mL/sec/cm3 0.000000 1 1 S01-03
43 E Liver extraction fraction 0.484950 0.000000 1 1 S01-03
44 Ktrans Hepatic plasma clearance 0.010678 mL/sec/cm3 0.000000 1 1 S01-03
45 H Hematocrit 0.418000 0.000000 1 2 S01-03
46 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-03
47 khe Hepatocellular uptake rate 0.017791 mL/sec/cm3 0.000773 1 2 S01-03
48 Th Hepatocellular mean transit time 392.098904 sec 20.157139 1 2 S01-03
49 Kbh Biliary tissue excretion rate 0.002550 mL/sec/cm3 0.000000 1 2 S01-03
50 Khe Hepatocellular tissue uptake rate 0.077352 mL/sec/cm3 0.000000 1 2 S01-03
51 kbh Biliary excretion rate 0.001964 mL/sec/cm3 0.000000 1 2 S01-03
52 E Liver extraction fraction 0.446896 0.000000 1 2 S01-03
53 Ktrans Hepatic plasma clearance 0.009840 mL/sec/cm3 0.000000 1 2 S01-03
54 H Hematocrit 0.418000 0.000000 1 1 S01-04
55 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-04
56 khe Hepatocellular uptake rate 0.011437 mL/sec/cm3 0.001050 1 1 S01-04
57 Th Hepatocellular mean transit time 409.157248 sec 45.720199 1 1 S01-04
58 Kbh Biliary tissue excretion rate 0.002444 mL/sec/cm3 0.000000 1 1 S01-04
59 Khe Hepatocellular tissue uptake rate 0.049726 mL/sec/cm3 0.000000 1 1 S01-04
60 kbh Biliary excretion rate 0.001882 mL/sec/cm3 0.000000 1 1 S01-04
61 E Liver extraction fraction 0.341853 0.000000 1 1 S01-04
62 Ktrans Hepatic plasma clearance 0.007527 mL/sec/cm3 0.000000 1 1 S01-04
63 H Hematocrit 0.418000 0.000000 1 2 S01-04
64 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-04
65 khe Hepatocellular uptake rate 0.006051 mL/sec/cm3 0.000481 1 2 S01-04
66 Th Hepatocellular mean transit time 712.406726 sec 88.350553 1 2 S01-04
67 Kbh Biliary tissue excretion rate 0.001404 mL/sec/cm3 0.000000 1 2 S01-04
68 Khe Hepatocellular tissue uptake rate 0.026308 mL/sec/cm3 0.000000 1 2 S01-04
69 kbh Biliary excretion rate 0.001081 mL/sec/cm3 0.000000 1 2 S01-04
70 E Liver extraction fraction 0.215562 0.000000 1 2 S01-04
71 Ktrans Hepatic plasma clearance 0.004746 mL/sec/cm3 0.000000 1 2 S01-04
72 H Hematocrit 0.418000 0.000000 1 1 S01-05
73 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-05
74 khe Hepatocellular uptake rate 0.024691 mL/sec/cm3 0.003274 1 1 S01-05
75 Th Hepatocellular mean transit time 207.612963 sec 29.316346 1 1 S01-05
76 Kbh Biliary tissue excretion rate 0.004817 mL/sec/cm3 0.000000 1 1 S01-05
77 Khe Hepatocellular tissue uptake rate 0.107352 mL/sec/cm3 0.000000 1 1 S01-05
78 kbh Biliary excretion rate 0.003709 mL/sec/cm3 0.000000 1 1 S01-05
79 E Liver extraction fraction 0.528601 0.000000 1 1 S01-05
80 Ktrans Hepatic plasma clearance 0.011639 mL/sec/cm3 0.000000 1 1 S01-05
81 H Hematocrit 0.418000 0.000000 1 2 S01-05
82 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-05
83 khe Hepatocellular uptake rate 0.002797 mL/sec/cm3 0.000424 1 2 S01-05
84 Th Hepatocellular mean transit time 737.024993 sec 178.889125 1 2 S01-05
85 Kbh Biliary tissue excretion rate 0.001357 mL/sec/cm3 0.000000 1 2 S01-05
86 Khe Hepatocellular tissue uptake rate 0.012161 mL/sec/cm3 0.000000 1 2 S01-05
87 kbh Biliary excretion rate 0.001045 mL/sec/cm3 0.000000 1 2 S01-05
88 E Liver extraction fraction 0.112714 0.000000 1 2 S01-05
89 Ktrans Hepatic plasma clearance 0.002482 mL/sec/cm3 0.000000 1 2 S01-05
90 H Hematocrit 0.418000 0.000000 1 1 S01-06
91 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-06
92 khe Hepatocellular uptake rate 0.020065 mL/sec/cm3 0.002657 1 1 S01-06
93 Th Hepatocellular mean transit time 235.655481 sec 33.845440 1 1 S01-06
94 Kbh Biliary tissue excretion rate 0.004243 mL/sec/cm3 0.000000 1 1 S01-06
95 Khe Hepatocellular tissue uptake rate 0.087239 mL/sec/cm3 0.000000 1 1 S01-06
96 kbh Biliary excretion rate 0.003267 mL/sec/cm3 0.000000 1 1 S01-06
97 E Liver extraction fraction 0.476784 0.000000 1 1 S01-06
98 Ktrans Hepatic plasma clearance 0.010498 mL/sec/cm3 0.000000 1 1 S01-06
99 H Hematocrit 0.418000 0.000000 1 2 S01-06
100 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-06
101 khe Hepatocellular uptake rate 0.004232 mL/sec/cm3 0.000535 1 2 S01-06
102 Th Hepatocellular mean transit time 570.914481 sec 101.110539 1 2 S01-06
103 Kbh Biliary tissue excretion rate 0.001752 mL/sec/cm3 0.000000 1 2 S01-06
104 Khe Hepatocellular tissue uptake rate 0.018401 mL/sec/cm3 0.000000 1 2 S01-06
105 kbh Biliary excretion rate 0.001349 mL/sec/cm3 0.000000 1 2 S01-06
106 E Liver extraction fraction 0.161218 0.000000 1 2 S01-06
107 Ktrans Hepatic plasma clearance 0.003550 mL/sec/cm3 0.000000 1 2 S01-06
108 H Hematocrit 0.418000 0.000000 2 1 S02-01
109 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-01
110 khe Hepatocellular uptake rate 0.037553 mL/sec/cm3 0.002281 2 1 S02-01
111 Th Hepatocellular mean transit time 262.914010 sec 17.072280 2 1 S02-01
112 Kbh Biliary tissue excretion rate 0.003804 mL/sec/cm3 0.000000 2 1 S02-01
113 Khe Hepatocellular tissue uptake rate 0.163274 mL/sec/cm3 0.000000 2 1 S02-01
114 kbh Biliary excretion rate 0.002929 mL/sec/cm3 0.000000 2 1 S02-01
115 E Liver extraction fraction 0.630380 0.000000 2 1 S02-01
116 Ktrans Hepatic plasma clearance 0.013880 mL/sec/cm3 0.000000 2 1 S02-01
117 H Hematocrit 0.418000 0.000000 2 2 S02-01
118 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-01
119 khe Hepatocellular uptake rate 0.009112 mL/sec/cm3 0.000716 2 2 S02-01
120 Th Hepatocellular mean transit time 272.981659 sec 24.397678 2 2 S02-01
121 Kbh Biliary tissue excretion rate 0.003663 mL/sec/cm3 0.000000 2 2 S02-01
122 Khe Hepatocellular tissue uptake rate 0.039617 mL/sec/cm3 0.000000 2 2 S02-01
123 kbh Biliary excretion rate 0.002821 mL/sec/cm3 0.000000 2 2 S02-01
124 E Liver extraction fraction 0.292696 0.000000 2 2 S02-01
125 Ktrans Hepatic plasma clearance 0.006445 mL/sec/cm3 0.000000 2 2 S02-01
126 H Hematocrit 0.418000 0.000000 2 1 S02-02
127 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-02
128 khe Hepatocellular uptake rate 0.046339 mL/sec/cm3 0.006089 2 1 S02-02
129 Th Hepatocellular mean transit time 144.489242 sec 19.573871 2 1 S02-02
130 Kbh Biliary tissue excretion rate 0.006921 mL/sec/cm3 0.000000 2 1 S02-02
131 Khe Hepatocellular tissue uptake rate 0.201472 mL/sec/cm3 0.000000 2 1 S02-02
132 kbh Biliary excretion rate 0.005329 mL/sec/cm3 0.000000 2 1 S02-02
133 E Liver extraction fraction 0.677885 0.000000 2 1 S02-02
134 Ktrans Hepatic plasma clearance 0.014926 mL/sec/cm3 0.000000 2 1 S02-02
135 H Hematocrit 0.418000 0.000000 2 2 S02-02
136 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-02
137 khe Hepatocellular uptake rate 0.026788 mL/sec/cm3 0.001283 2 2 S02-02
138 Th Hepatocellular mean transit time 268.125043 sec 14.044691 2 2 S02-02
139 Kbh Biliary tissue excretion rate 0.003730 mL/sec/cm3 0.000000 2 2 S02-02
140 Khe Hepatocellular tissue uptake rate 0.116470 mL/sec/cm3 0.000000 2 2 S02-02
141 kbh Biliary excretion rate 0.002872 mL/sec/cm3 0.000000 2 2 S02-02
142 E Liver extraction fraction 0.548856 0.000000 2 2 S02-02
143 Ktrans Hepatic plasma clearance 0.012085 mL/sec/cm3 0.000000 2 2 S02-02
144 H Hematocrit 0.418000 0.000000 2 1 S02-03
145 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-03
146 khe Hepatocellular uptake rate 0.042612 mL/sec/cm3 0.003651 2 1 S02-03
147 Th Hepatocellular mean transit time 155.287619 sec 13.798939 2 1 S02-03
148 Kbh Biliary tissue excretion rate 0.006440 mL/sec/cm3 0.000000 2 1 S02-03
149 Khe Hepatocellular tissue uptake rate 0.185268 mL/sec/cm3 0.000000 2 1 S02-03
150 kbh Biliary excretion rate 0.004959 mL/sec/cm3 0.000000 2 1 S02-03
151 E Liver extraction fraction 0.659310 0.000000 2 1 S02-03
152 Ktrans Hepatic plasma clearance 0.014517 mL/sec/cm3 0.000000 2 1 S02-03
153 H Hematocrit 0.418000 0.000000 2 2 S02-03
154 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-03
155 khe Hepatocellular uptake rate 0.029486 mL/sec/cm3 0.002314 2 2 S02-03
156 Th Hepatocellular mean transit time 166.931971 sec 13.883798 2 2 S02-03
157 Kbh Biliary tissue excretion rate 0.005990 mL/sec/cm3 0.000000 2 2 S02-03
158 Khe Hepatocellular tissue uptake rate 0.128199 mL/sec/cm3 0.000000 2 2 S02-03
159 kbh Biliary excretion rate 0.004613 mL/sec/cm3 0.000000 2 2 S02-03
160 E Liver extraction fraction 0.572485 0.000000 2 2 S02-03
161 Ktrans Hepatic plasma clearance 0.012606 mL/sec/cm3 0.000000 2 2 S02-03
162 H Hematocrit 0.418000 0.000000 2 1 S02-04
163 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-04
164 khe Hepatocellular uptake rate 0.024529 mL/sec/cm3 0.001685 2 1 S02-04
165 Th Hepatocellular mean transit time 176.772736 sec 12.998496 2 1 S02-04
166 Kbh Biliary tissue excretion rate 0.005657 mL/sec/cm3 0.000000 2 1 S02-04
167 Khe Hepatocellular tissue uptake rate 0.106649 mL/sec/cm3 0.000000 2 1 S02-04
168 kbh Biliary excretion rate 0.004356 mL/sec/cm3 0.000000 2 1 S02-04
169 E Liver extraction fraction 0.526963 0.000000 2 1 S02-04
170 Ktrans Hepatic plasma clearance 0.011603 mL/sec/cm3 0.000000 2 1 S02-04
171 H Hematocrit 0.418000 0.000000 2 2 S02-04
172 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-04
173 khe Hepatocellular uptake rate 0.002012 mL/sec/cm3 0.000273 2 2 S02-04
174 Th Hepatocellular mean transit time 665.775347 sec 137.384826 2 2 S02-04
175 Kbh Biliary tissue excretion rate 0.001502 mL/sec/cm3 0.000000 2 2 S02-04
176 Khe Hepatocellular tissue uptake rate 0.008747 mL/sec/cm3 0.000000 2 2 S02-04
177 kbh Biliary excretion rate 0.001157 mL/sec/cm3 0.000000 2 2 S02-04
178 E Liver extraction fraction 0.083720 0.000000 2 2 S02-04
179 Ktrans Hepatic plasma clearance 0.001843 mL/sec/cm3 0.000000 2 2 S02-04
180 H Hematocrit 0.418000 0.000000 2 1 S02-05
181 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-05
182 khe Hepatocellular uptake rate 0.015487 mL/sec/cm3 0.001692 2 1 S02-05
183 Th Hepatocellular mean transit time 137.937824 sec 16.288495 2 1 S02-05
184 Kbh Biliary tissue excretion rate 0.007250 mL/sec/cm3 0.000000 2 1 S02-05
185 Khe Hepatocellular tissue uptake rate 0.067334 mL/sec/cm3 0.000000 2 1 S02-05
186 kbh Biliary excretion rate 0.005582 mL/sec/cm3 0.000000 2 1 S02-05
187 E Liver extraction fraction 0.412917 0.000000 2 1 S02-05
188 Ktrans Hepatic plasma clearance 0.009092 mL/sec/cm3 0.000000 2 1 S02-05
189 H Hematocrit 0.418000 0.000000 2 2 S02-05
190 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-05
191 khe Hepatocellular uptake rate 0.005127 mL/sec/cm3 0.000557 2 2 S02-05
192 Th Hepatocellular mean transit time 446.263349 sec 61.828233 2 2 S02-05
193 Kbh Biliary tissue excretion rate 0.002241 mL/sec/cm3 0.000000 2 2 S02-05
194 Khe Hepatocellular tissue uptake rate 0.022292 mL/sec/cm3 0.000000 2 2 S02-05
195 kbh Biliary excretion rate 0.001725 mL/sec/cm3 0.000000 2 2 S02-05
196 E Liver extraction fraction 0.188871 0.000000 2 2 S02-05
197 Ktrans Hepatic plasma clearance 0.004159 mL/sec/cm3 0.000000 2 2 S02-05
198 H Hematocrit 0.418000 0.000000 2 1 S02-06
199 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-06
200 khe Hepatocellular uptake rate 0.024838 mL/sec/cm3 0.001156 2 1 S02-06
201 Th Hepatocellular mean transit time 273.362928 sec 13.997410 2 1 S02-06
202 Kbh Biliary tissue excretion rate 0.003658 mL/sec/cm3 0.000000 2 1 S02-06
203 Khe Hepatocellular tissue uptake rate 0.107989 mL/sec/cm3 0.000000 2 1 S02-06
204 kbh Biliary excretion rate 0.002817 mL/sec/cm3 0.000000 2 1 S02-06
205 E Liver extraction fraction 0.530077 0.000000 2 1 S02-06
206 Ktrans Hepatic plasma clearance 0.011672 mL/sec/cm3 0.000000 2 1 S02-06
207 H Hematocrit 0.418000 0.000000 2 2 S02-06
208 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-06
209 khe Hepatocellular uptake rate 0.005436 mL/sec/cm3 0.000346 2 2 S02-06
210 Th Hepatocellular mean transit time 521.114358 sec 44.688732 2 2 S02-06
211 Kbh Biliary tissue excretion rate 0.001919 mL/sec/cm3 0.000000 2 2 S02-06
212 Khe Hepatocellular tissue uptake rate 0.023633 mL/sec/cm3 0.000000 2 2 S02-06
213 kbh Biliary excretion rate 0.001478 mL/sec/cm3 0.000000 2 2 S02-06
214 E Liver extraction fraction 0.197984 0.000000 2 2 S02-06
215 Ktrans Hepatic plasma clearance 0.004359 mL/sec/cm3 0.000000 2 2 S02-06
216 H Hematocrit 0.418000 0.000000 3 1 S03-01
217 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-01
218 khe Hepatocellular uptake rate 0.024023 mL/sec/cm3 0.001109 3 1 S03-01
219 Th Hepatocellular mean transit time 312.195533 sec 16.179354 3 1 S03-01
220 Kbh Biliary tissue excretion rate 0.003203 mL/sec/cm3 0.000000 3 1 S03-01
221 Khe Hepatocellular tissue uptake rate 0.104449 mL/sec/cm3 0.000000 3 1 S03-01
222 kbh Biliary excretion rate 0.002466 mL/sec/cm3 0.000000 3 1 S03-01
223 E Liver extraction fraction 0.521766 0.000000 3 1 S03-01
224 Ktrans Hepatic plasma clearance 0.011489 mL/sec/cm3 0.000000 3 1 S03-01
225 H Hematocrit 0.418000 0.000000 3 2 S03-01
226 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-01
227 khe Hepatocellular uptake rate 0.034071 mL/sec/cm3 0.002178 3 2 S03-01
228 Th Hepatocellular mean transit time 229.896375 sec 15.643979 3 2 S03-01
229 Kbh Biliary tissue excretion rate 0.004350 mL/sec/cm3 0.000000 3 2 S03-01
230 Khe Hepatocellular tissue uptake rate 0.148137 mL/sec/cm3 0.000000 3 2 S03-01
231 kbh Biliary excretion rate 0.003349 mL/sec/cm3 0.000000 3 2 S03-01
232 E Liver extraction fraction 0.607438 0.000000 3 2 S03-01
233 Ktrans Hepatic plasma clearance 0.013375 mL/sec/cm3 0.000000 3 2 S03-01
234 H Hematocrit 0.418000 0.000000 3 1 S03-02
235 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-02
236 khe Hepatocellular uptake rate 0.027256 mL/sec/cm3 0.001718 3 1 S03-02
237 Th Hepatocellular mean transit time 320.467865 sec 22.611328 3 1 S03-02
238 Kbh Biliary tissue excretion rate 0.003120 mL/sec/cm3 0.000000 3 1 S03-02
239 Khe Hepatocellular tissue uptake rate 0.118505 mL/sec/cm3 0.000000 3 1 S03-02
240 kbh Biliary excretion rate 0.002403 mL/sec/cm3 0.000000 3 1 S03-02
241 E Liver extraction fraction 0.553141 0.000000 3 1 S03-02
242 Ktrans Hepatic plasma clearance 0.012180 mL/sec/cm3 0.000000 3 1 S03-02
243 H Hematocrit 0.418000 0.000000 3 2 S03-02
244 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-02
245 khe Hepatocellular uptake rate 0.018993 mL/sec/cm3 0.002042 3 2 S03-02
246 Th Hepatocellular mean transit time 383.292674 sec 48.765401 3 2 S03-02
247 Kbh Biliary tissue excretion rate 0.002609 mL/sec/cm3 0.000000 3 2 S03-02
248 Khe Hepatocellular tissue uptake rate 0.082578 mL/sec/cm3 0.000000 3 2 S03-02
249 kbh Biliary excretion rate 0.002009 mL/sec/cm3 0.000000 3 2 S03-02
250 E Liver extraction fraction 0.463107 0.000000 3 2 S03-02
251 Ktrans Hepatic plasma clearance 0.010197 mL/sec/cm3 0.000000 3 2 S03-02
252 H Hematocrit 0.418000 0.000000 3 1 S03-03
253 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-03
254 khe Hepatocellular uptake rate 0.021736 mL/sec/cm3 0.000685 3 1 S03-03
255 Th Hepatocellular mean transit time 320.805579 sec 11.449094 3 1 S03-03
256 Kbh Biliary tissue excretion rate 0.003117 mL/sec/cm3 0.000000 3 1 S03-03
257 Khe Hepatocellular tissue uptake rate 0.094503 mL/sec/cm3 0.000000 3 1 S03-03
258 kbh Biliary excretion rate 0.002400 mL/sec/cm3 0.000000 3 1 S03-03
259 E Liver extraction fraction 0.496764 0.000000 3 1 S03-03
260 Ktrans Hepatic plasma clearance 0.010938 mL/sec/cm3 0.000000 3 1 S03-03
261 H Hematocrit 0.418000 0.000000 3 2 S03-03
262 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-03
263 khe Hepatocellular uptake rate 0.017769 mL/sec/cm3 0.001324 3 2 S03-03
264 Th Hepatocellular mean transit time 276.567242 sec 23.043210 3 2 S03-03
265 Kbh Biliary tissue excretion rate 0.003616 mL/sec/cm3 0.000000 3 2 S03-03
266 Khe Hepatocellular tissue uptake rate 0.077258 mL/sec/cm3 0.000000 3 2 S03-03
267 kbh Biliary excretion rate 0.002784 mL/sec/cm3 0.000000 3 2 S03-03
268 E Liver extraction fraction 0.446596 0.000000 3 2 S03-03
269 Ktrans Hepatic plasma clearance 0.009834 mL/sec/cm3 0.000000 3 2 S03-03
270 H Hematocrit 0.418000 0.000000 3 1 S03-04
271 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-04
272 khe Hepatocellular uptake rate 0.034191 mL/sec/cm3 0.002869 3 1 S03-04
273 Th Hepatocellular mean transit time 281.281632 sec 25.575679 3 1 S03-04
274 Kbh Biliary tissue excretion rate 0.003555 mL/sec/cm3 0.000000 3 1 S03-04
275 Khe Hepatocellular tissue uptake rate 0.148656 mL/sec/cm3 0.000000 3 1 S03-04
276 kbh Biliary excretion rate 0.002737 mL/sec/cm3 0.000000 3 1 S03-04
277 E Liver extraction fraction 0.608271 0.000000 3 1 S03-04
278 Ktrans Hepatic plasma clearance 0.013394 mL/sec/cm3 0.000000 3 1 S03-04
279 H Hematocrit 0.418000 0.000000 3 2 S03-04
280 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-04
281 khe Hepatocellular uptake rate 0.000882 mL/sec/cm3 0.000113 3 2 S03-04
282 Th Hepatocellular mean transit time 65625.454312 sec 242620.440873 3 2 S03-04
283 Kbh Biliary tissue excretion rate 0.000015 mL/sec/cm3 0.000000 3 2 S03-04
284 Khe Hepatocellular tissue uptake rate 0.003837 mL/sec/cm3 0.000000 3 2 S03-04
285 kbh Biliary excretion rate 0.000012 mL/sec/cm3 0.000000 3 2 S03-04
286 E Liver extraction fraction 0.038533 0.000000 3 2 S03-04
287 Ktrans Hepatic plasma clearance 0.000848 mL/sec/cm3 0.000000 3 2 S03-04
288 H Hematocrit 0.418000 0.000000 3 1 S03-05
289 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-05
290 khe Hepatocellular uptake rate 0.019442 mL/sec/cm3 0.001310 3 1 S03-05
291 Th Hepatocellular mean transit time 273.275488 sec 20.847519 3 1 S03-05
292 Kbh Biliary tissue excretion rate 0.003659 mL/sec/cm3 0.000000 3 1 S03-05
293 Khe Hepatocellular tissue uptake rate 0.084532 mL/sec/cm3 0.000000 3 1 S03-05
294 kbh Biliary excretion rate 0.002818 mL/sec/cm3 0.000000 3 1 S03-05
295 E Liver extraction fraction 0.468929 0.000000 3 1 S03-05
296 Ktrans Hepatic plasma clearance 0.010325 mL/sec/cm3 0.000000 3 1 S03-05
297 H Hematocrit 0.418000 0.000000 3 2 S03-05
298 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-05
299 khe Hepatocellular uptake rate 0.002662 mL/sec/cm3 0.000265 3 2 S03-05
300 Th Hepatocellular mean transit time 2096.750917 sec 748.034858 3 2 S03-05
301 Kbh Biliary tissue excretion rate 0.000477 mL/sec/cm3 0.000000 3 2 S03-05
302 Khe Hepatocellular tissue uptake rate 0.011575 mL/sec/cm3 0.000000 3 2 S03-05
303 kbh Biliary excretion rate 0.000367 mL/sec/cm3 0.000000 3 2 S03-05
304 E Liver extraction fraction 0.107865 0.000000 3 2 S03-05
305 Ktrans Hepatic plasma clearance 0.002375 mL/sec/cm3 0.000000 3 2 S03-05
306 H Hematocrit 0.418000 0.000000 3 1 S03-06
307 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-06
308 khe Hepatocellular uptake rate 0.018851 mL/sec/cm3 0.001438 3 1 S03-06
309 Th Hepatocellular mean transit time 361.106760 sec 33.865350 3 1 S03-06
310 Kbh Biliary tissue excretion rate 0.002769 mL/sec/cm3 0.000000 3 1 S03-06
311 Khe Hepatocellular tissue uptake rate 0.081959 mL/sec/cm3 0.000000 3 1 S03-06
312 kbh Biliary excretion rate 0.002132 mL/sec/cm3 0.000000 3 1 S03-06
313 E Liver extraction fraction 0.461238 0.000000 3 1 S03-06
314 Ktrans Hepatic plasma clearance 0.010156 mL/sec/cm3 0.000000 3 1 S03-06
315 H Hematocrit 0.418000 0.000000 3 2 S03-06
316 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-06
317 khe Hepatocellular uptake rate 0.002589 mL/sec/cm3 0.000266 3 2 S03-06
318 Th Hepatocellular mean transit time 1829.494917 sec 578.840780 3 2 S03-06
319 Kbh Biliary tissue excretion rate 0.000547 mL/sec/cm3 0.000000 3 2 S03-06
320 Khe Hepatocellular tissue uptake rate 0.011257 mL/sec/cm3 0.000000 3 2 S03-06
321 kbh Biliary excretion rate 0.000421 mL/sec/cm3 0.000000 3 2 S03-06
322 E Liver extraction fraction 0.105215 0.000000 3 2 S03-06
323 Ktrans Hepatic plasma clearance 0.002317 mL/sec/cm3 0.000000 3 2 S03-06
324 H Hematocrit 0.418000 0.000000 4 1 S04-01
325 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-01
326 khe Hepatocellular uptake rate 0.020679 mL/sec/cm3 0.001289 4 1 S04-01
327 Th Hepatocellular mean transit time 301.166410 sec 20.836217 4 1 S04-01
328 Kbh Biliary tissue excretion rate 0.003320 mL/sec/cm3 0.000000 4 1 S04-01
329 Khe Hepatocellular tissue uptake rate 0.089909 mL/sec/cm3 0.000000 4 1 S04-01
330 kbh Biliary excretion rate 0.002557 mL/sec/cm3 0.000000 4 1 S04-01
331 E Liver extraction fraction 0.484309 0.000000 4 1 S04-01
332 Ktrans Hepatic plasma clearance 0.010664 mL/sec/cm3 0.000000 4 1 S04-01
333 H Hematocrit 0.418000 0.000000 4 2 S04-01
334 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-01
335 khe Hepatocellular uptake rate 0.025041 mL/sec/cm3 0.001390 4 2 S04-01
336 Th Hepatocellular mean transit time 395.811923 sec 25.537122 4 2 S04-01
337 Kbh Biliary tissue excretion rate 0.002526 mL/sec/cm3 0.000000 4 2 S04-01
338 Khe Hepatocellular tissue uptake rate 0.108874 mL/sec/cm3 0.000000 4 2 S04-01
339 kbh Biliary excretion rate 0.001945 mL/sec/cm3 0.000000 4 2 S04-01
340 E Liver extraction fraction 0.532108 0.000000 4 2 S04-01
341 Ktrans Hepatic plasma clearance 0.011716 mL/sec/cm3 0.000000 4 2 S04-01
342 H Hematocrit 0.418000 0.000000 4 1 S04-02
343 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-02
344 khe Hepatocellular uptake rate 0.018306 mL/sec/cm3 0.001540 4 1 S04-02
345 Th Hepatocellular mean transit time 274.999596 sec 25.530787 4 1 S04-02
346 Kbh Biliary tissue excretion rate 0.003636 mL/sec/cm3 0.000000 4 1 S04-02
347 Khe Hepatocellular tissue uptake rate 0.079591 mL/sec/cm3 0.000000 4 1 S04-02
348 kbh Biliary excretion rate 0.002800 mL/sec/cm3 0.000000 4 1 S04-02
349 E Liver extraction fraction 0.453961 0.000000 4 1 S04-02
350 Ktrans Hepatic plasma clearance 0.009996 mL/sec/cm3 0.000000 4 1 S04-02
351 H Hematocrit 0.418000 0.000000 4 2 S04-02
352 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-02
353 khe Hepatocellular uptake rate 0.025679 mL/sec/cm3 0.001795 4 2 S04-02
354 Th Hepatocellular mean transit time 215.892033 sec 16.038397 4 2 S04-02
355 Kbh Biliary tissue excretion rate 0.004632 mL/sec/cm3 0.000000 4 2 S04-02
356 Khe Hepatocellular tissue uptake rate 0.111647 mL/sec/cm3 0.000000 4 2 S04-02
357 kbh Biliary excretion rate 0.003567 mL/sec/cm3 0.000000 4 2 S04-02
358 E Liver extraction fraction 0.538365 0.000000 4 2 S04-02
359 Ktrans Hepatic plasma clearance 0.011854 mL/sec/cm3 0.000000 4 2 S04-02
360 H Hematocrit 0.418000 0.000000 4 1 S04-03
361 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-03
362 khe Hepatocellular uptake rate 0.030104 mL/sec/cm3 0.002602 4 1 S04-03
363 Th Hepatocellular mean transit time 166.642085 sec 15.038239 4 1 S04-03
364 Kbh Biliary tissue excretion rate 0.006001 mL/sec/cm3 0.000000 4 1 S04-03
365 Khe Hepatocellular tissue uptake rate 0.130887 mL/sec/cm3 0.000000 4 1 S04-03
366 kbh Biliary excretion rate 0.004621 mL/sec/cm3 0.000000 4 1 S04-03
367 E Liver extraction fraction 0.577556 0.000000 4 1 S04-03
368 Ktrans Hepatic plasma clearance 0.012717 mL/sec/cm3 0.000000 4 1 S04-03
369 H Hematocrit 0.418000 0.000000 4 2 S04-03
370 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-03
371 khe Hepatocellular uptake rate 0.031763 mL/sec/cm3 0.002446 4 2 S04-03
372 Th Hepatocellular mean transit time 201.235422 sec 16.207187 4 2 S04-03
373 Kbh Biliary tissue excretion rate 0.004969 mL/sec/cm3 0.000000 4 2 S04-03
374 Khe Hepatocellular tissue uptake rate 0.138099 mL/sec/cm3 0.000000 4 2 S04-03
375 kbh Biliary excretion rate 0.003826 mL/sec/cm3 0.000000 4 2 S04-03
376 E Liver extraction fraction 0.590586 0.000000 4 2 S04-03
377 Ktrans Hepatic plasma clearance 0.013004 mL/sec/cm3 0.000000 4 2 S04-03
378 H Hematocrit 0.418000 0.000000 4 1 S04-04
379 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-04
380 khe Hepatocellular uptake rate 0.024781 mL/sec/cm3 0.001929 4 1 S04-04
381 Th Hepatocellular mean transit time 215.455531 sec 17.860634 4 1 S04-04
382 Kbh Biliary tissue excretion rate 0.004641 mL/sec/cm3 0.000000 4 1 S04-04
383 Khe Hepatocellular tissue uptake rate 0.107745 mL/sec/cm3 0.000000 4 1 S04-04
384 kbh Biliary excretion rate 0.003574 mL/sec/cm3 0.000000 4 1 S04-04
385 E Liver extraction fraction 0.529513 0.000000 4 1 S04-04
386 Ktrans Hepatic plasma clearance 0.011659 mL/sec/cm3 0.000000 4 1 S04-04
387 H Hematocrit 0.418000 0.000000 4 2 S04-04
388 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-04
389 khe Hepatocellular uptake rate 0.031542 mL/sec/cm3 0.001530 4 2 S04-04
390 Th Hepatocellular mean transit time 221.315703 sec 11.280667 4 2 S04-04
391 Kbh Biliary tissue excretion rate 0.004518 mL/sec/cm3 0.000000 4 2 S04-04
392 Khe Hepatocellular tissue uptake rate 0.137139 mL/sec/cm3 0.000000 4 2 S04-04
393 kbh Biliary excretion rate 0.003479 mL/sec/cm3 0.000000 4 2 S04-04
394 E Liver extraction fraction 0.588899 0.000000 4 2 S04-04
395 Ktrans Hepatic plasma clearance 0.012967 mL/sec/cm3 0.000000 4 2 S04-04
396 H Hematocrit 0.418000 0.000000 4 1 S04-05
397 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-05
398 khe Hepatocellular uptake rate 0.023245 mL/sec/cm3 0.001360 4 1 S04-05
399 Th Hepatocellular mean transit time 318.561744 sec 20.737505 4 1 S04-05
400 Kbh Biliary tissue excretion rate 0.003139 mL/sec/cm3 0.000000 4 1 S04-05
401 Khe Hepatocellular tissue uptake rate 0.101067 mL/sec/cm3 0.000000 4 1 S04-05
402 kbh Biliary excretion rate 0.002417 mL/sec/cm3 0.000000 4 1 S04-05
403 E Liver extraction fraction 0.513548 0.000000 4 1 S04-05
404 Ktrans Hepatic plasma clearance 0.011308 mL/sec/cm3 0.000000 4 1 S04-05
405 H Hematocrit 0.418000 0.000000 4 2 S04-05
406 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-05
407 khe Hepatocellular uptake rate 0.006419 mL/sec/cm3 0.000641 4 2 S04-05
408 Th Hepatocellular mean transit time 834.723557 sec 142.471249 4 2 S04-05
409 Kbh Biliary tissue excretion rate 0.001198 mL/sec/cm3 0.000000 4 2 S04-05
410 Khe Hepatocellular tissue uptake rate 0.027908 mL/sec/cm3 0.000000 4 2 S04-05
411 kbh Biliary excretion rate 0.000922 mL/sec/cm3 0.000000 4 2 S04-05
412 E Liver extraction fraction 0.225716 0.000000 4 2 S04-05
413 Ktrans Hepatic plasma clearance 0.004970 mL/sec/cm3 0.000000 4 2 S04-05
414 H Hematocrit 0.418000 0.000000 4 1 S04-06
415 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-06
416 khe Hepatocellular uptake rate 0.026134 mL/sec/cm3 0.001719 4 1 S04-06
417 Th Hepatocellular mean transit time 201.798523 sec 14.051229 4 1 S04-06
418 Kbh Biliary tissue excretion rate 0.004955 mL/sec/cm3 0.000000 4 1 S04-06
419 Khe Hepatocellular tissue uptake rate 0.113624 mL/sec/cm3 0.000000 4 1 S04-06
420 kbh Biliary excretion rate 0.003816 mL/sec/cm3 0.000000 4 1 S04-06
421 E Liver extraction fraction 0.542725 0.000000 4 1 S04-06
422 Ktrans Hepatic plasma clearance 0.011950 mL/sec/cm3 0.000000 4 1 S04-06
423 H Hematocrit 0.418000 0.000000 4 2 S04-06
424 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-06
425 khe Hepatocellular uptake rate 0.004853 mL/sec/cm3 0.000434 4 2 S04-06
426 Th Hepatocellular mean transit time 603.017578 sec 77.246780 4 2 S04-06
427 Kbh Biliary tissue excretion rate 0.001658 mL/sec/cm3 0.000000 4 2 S04-06
428 Khe Hepatocellular tissue uptake rate 0.021100 mL/sec/cm3 0.000000 4 2 S04-06
429 kbh Biliary excretion rate 0.001277 mL/sec/cm3 0.000000 4 2 S04-06
430 E Liver extraction fraction 0.180600 0.000000 4 2 S04-06
431 Ktrans Hepatic plasma clearance 0.003977 mL/sec/cm3 0.000000 4 2 S04-06
432 H Hematocrit 0.418000 0.000000 4 1 S04-07
433 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-07
434 khe Hepatocellular uptake rate 0.028803 mL/sec/cm3 0.001777 4 1 S04-07
435 Th Hepatocellular mean transit time 199.383467 sec 12.937531 4 1 S04-07
436 Kbh Biliary tissue excretion rate 0.005015 mL/sec/cm3 0.000000 4 1 S04-07
437 Khe Hepatocellular tissue uptake rate 0.125230 mL/sec/cm3 0.000000 4 1 S04-07
438 kbh Biliary excretion rate 0.003862 mL/sec/cm3 0.000000 4 1 S04-07
439 E Liver extraction fraction 0.566742 0.000000 4 1 S04-07
440 Ktrans Hepatic plasma clearance 0.012479 mL/sec/cm3 0.000000 4 1 S04-07
441 H Hematocrit 0.418000 0.000000 4 2 S04-07
442 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-07
443 khe Hepatocellular uptake rate 0.006605 mL/sec/cm3 0.000604 4 2 S04-07
444 Th Hepatocellular mean transit time 598.552559 sec 77.794632 4 2 S04-07
445 Kbh Biliary tissue excretion rate 0.001671 mL/sec/cm3 0.000000 4 2 S04-07
446 Khe Hepatocellular tissue uptake rate 0.028719 mL/sec/cm3 0.000000 4 2 S04-07
447 kbh Biliary excretion rate 0.001286 mL/sec/cm3 0.000000 4 2 S04-07
448 E Liver extraction fraction 0.230758 0.000000 4 2 S04-07
449 Ktrans Hepatic plasma clearance 0.005081 mL/sec/cm3 0.000000 4 2 S04-07
450 H Hematocrit 0.418000 0.000000 4 1 S04-08
451 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 1 S04-08
452 khe Hepatocellular uptake rate 0.021571 mL/sec/cm3 0.001307 4 1 S04-08
453 Th Hepatocellular mean transit time 213.542713 sec 13.877482 4 1 S04-08
454 Kbh Biliary tissue excretion rate 0.004683 mL/sec/cm3 0.000000 4 1 S04-08
455 Khe Hepatocellular tissue uptake rate 0.093788 mL/sec/cm3 0.000000 4 1 S04-08
456 kbh Biliary excretion rate 0.003606 mL/sec/cm3 0.000000 4 1 S04-08
457 E Liver extraction fraction 0.494865 0.000000 4 1 S04-08
458 Ktrans Hepatic plasma clearance 0.010896 mL/sec/cm3 0.000000 4 1 S04-08
459 H Hematocrit 0.418000 0.000000 4 2 S04-08
460 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 4 2 S04-08
461 khe Hepatocellular uptake rate 0.006650 mL/sec/cm3 0.000648 4 2 S04-08
462 Th Hepatocellular mean transit time 661.958695 sec 96.443350 4 2 S04-08
463 Kbh Biliary tissue excretion rate 0.001511 mL/sec/cm3 0.000000 4 2 S04-08
464 Khe Hepatocellular tissue uptake rate 0.028915 mL/sec/cm3 0.000000 4 2 S04-08
465 kbh Biliary excretion rate 0.001163 mL/sec/cm3 0.000000 4 2 S04-08
466 E Liver extraction fraction 0.231968 0.000000 4 2 S04-08
467 Ktrans Hepatic plasma clearance 0.005108 mL/sec/cm3 0.000000 4 2 S04-08
468 H Hematocrit 0.418000 0.000000 5 1 S05-01
469 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-01
470 khe Hepatocellular uptake rate 0.027413 mL/sec/cm3 0.001682 5 1 S05-01
471 Th Hepatocellular mean transit time 246.731319 sec 16.406922 5 1 S05-01
472 Kbh Biliary tissue excretion rate 0.004053 mL/sec/cm3 0.000000 5 1 S05-01
473 Khe Hepatocellular tissue uptake rate 0.119189 mL/sec/cm3 0.000000 5 1 S05-01
474 kbh Biliary excretion rate 0.003121 mL/sec/cm3 0.000000 5 1 S05-01
475 E Liver extraction fraction 0.554563 0.000000 5 1 S05-01
476 Ktrans Hepatic plasma clearance 0.012211 mL/sec/cm3 0.000000 5 1 S05-01
477 H Hematocrit 0.418000 0.000000 5 1 S05-02
478 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-02
479 khe Hepatocellular uptake rate 0.029190 mL/sec/cm3 0.000690 5 1 S05-02
480 Th Hepatocellular mean transit time 192.246433 sec 4.836834 5 1 S05-02
481 Kbh Biliary tissue excretion rate 0.005202 mL/sec/cm3 0.000000 5 1 S05-02
482 Khe Hepatocellular tissue uptake rate 0.126911 mL/sec/cm3 0.000000 5 1 S05-02
483 kbh Biliary excretion rate 0.004005 mL/sec/cm3 0.000000 5 1 S05-02
484 E Liver extraction fraction 0.570014 0.000000 5 1 S05-02
485 Ktrans Hepatic plasma clearance 0.012551 mL/sec/cm3 0.000000 5 1 S05-02
486 H Hematocrit 0.418000 0.000000 5 1 S05-03
487 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-03
488 khe Hepatocellular uptake rate 0.023123 mL/sec/cm3 0.002281 5 1 S05-03
489 Th Hepatocellular mean transit time 154.454455 sec 16.290498 5 1 S05-03
490 Kbh Biliary tissue excretion rate 0.006474 mL/sec/cm3 0.000000 5 1 S05-03
491 Khe Hepatocellular tissue uptake rate 0.100536 mL/sec/cm3 0.000000 5 1 S05-03
492 kbh Biliary excretion rate 0.004985 mL/sec/cm3 0.000000 5 1 S05-03
493 E Liver extraction fraction 0.512232 0.000000 5 1 S05-03
494 Ktrans Hepatic plasma clearance 0.011279 mL/sec/cm3 0.000000 5 1 S05-03
495 H Hematocrit 0.418000 0.000000 5 1 S05-04
496 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-04
497 khe Hepatocellular uptake rate 0.017874 mL/sec/cm3 0.000788 5 1 S05-04
498 Th Hepatocellular mean transit time 185.344175 sec 8.871480 5 1 S05-04
499 Kbh Biliary tissue excretion rate 0.005395 mL/sec/cm3 0.000000 5 1 S05-04
500 Khe Hepatocellular tissue uptake rate 0.077715 mL/sec/cm3 0.000000 5 1 S05-04
501 kbh Biliary excretion rate 0.004154 mL/sec/cm3 0.000000 5 1 S05-04
502 E Liver extraction fraction 0.448054 0.000000 5 1 S05-04
503 Ktrans Hepatic plasma clearance 0.009866 mL/sec/cm3 0.000000 5 1 S05-04
504 H Hematocrit 0.418000 0.000000 5 1 S05-05
505 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-05
506 khe Hepatocellular uptake rate 0.015750 mL/sec/cm3 0.001193 5 1 S05-05
507 Th Hepatocellular mean transit time 194.627433 sec 16.106847 5 1 S05-05
508 Kbh Biliary tissue excretion rate 0.005138 mL/sec/cm3 0.000000 5 1 S05-05
509 Khe Hepatocellular tissue uptake rate 0.068477 mL/sec/cm3 0.000000 5 1 S05-05
510 kbh Biliary excretion rate 0.003956 mL/sec/cm3 0.000000 5 1 S05-05
511 E Liver extraction fraction 0.417006 0.000000 5 1 S05-05
512 Ktrans Hepatic plasma clearance 0.009182 mL/sec/cm3 0.000000 5 1 S05-05
513 H Hematocrit 0.418000 0.000000 5 1 S05-06
514 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 5 1 S05-06
515 khe Hepatocellular uptake rate 0.017684 mL/sec/cm3 0.001342 5 1 S05-06
516 Th Hepatocellular mean transit time 171.878130 sec 14.125022 5 1 S05-06
517 Kbh Biliary tissue excretion rate 0.005818 mL/sec/cm3 0.000000 5 1 S05-06
518 Khe Hepatocellular tissue uptake rate 0.076888 mL/sec/cm3 0.000000 5 1 S05-06
519 kbh Biliary excretion rate 0.004480 mL/sec/cm3 0.000000 5 1 S05-06
520 E Liver extraction fraction 0.445411 0.000000 5 1 S05-06
521 Ktrans Hepatic plasma clearance 0.009808 mL/sec/cm3 0.000000 5 1 S05-06
522 H Hematocrit 0.418000 0.000000 6 1 S06-01
523 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-01
524 khe Hepatocellular uptake rate 0.023093 mL/sec/cm3 0.001939 6 1 S06-01
525 Th Hepatocellular mean transit time 180.090839 sec 16.235359 6 1 S06-01
526 Kbh Biliary tissue excretion rate 0.005553 mL/sec/cm3 0.000000 6 1 S06-01
527 Khe Hepatocellular tissue uptake rate 0.100406 mL/sec/cm3 0.000000 6 1 S06-01
528 kbh Biliary excretion rate 0.004276 mL/sec/cm3 0.000000 6 1 S06-01
529 E Liver extraction fraction 0.511909 0.000000 6 1 S06-01
530 Ktrans Hepatic plasma clearance 0.011272 mL/sec/cm3 0.000000 6 1 S06-01
531 H Hematocrit 0.418000 0.000000 6 1 S06-02
532 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-02
533 khe Hepatocellular uptake rate 0.029692 mL/sec/cm3 0.001751 6 1 S06-02
534 Th Hepatocellular mean transit time 210.523275 sec 13.254362 6 1 S06-02
535 Kbh Biliary tissue excretion rate 0.004750 mL/sec/cm3 0.000000 6 1 S06-02
536 Khe Hepatocellular tissue uptake rate 0.129094 mL/sec/cm3 0.000000 6 1 S06-02
537 kbh Biliary excretion rate 0.003658 mL/sec/cm3 0.000000 6 1 S06-02
538 E Liver extraction fraction 0.574188 0.000000 6 1 S06-02
539 Ktrans Hepatic plasma clearance 0.012643 mL/sec/cm3 0.000000 6 1 S06-02
540 H Hematocrit 0.418000 0.000000 6 1 S06-03
541 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-03
542 khe Hepatocellular uptake rate 0.025392 mL/sec/cm3 0.002823 6 1 S06-03
543 Th Hepatocellular mean transit time 162.886138 sec 19.312284 6 1 S06-03
544 Kbh Biliary tissue excretion rate 0.006139 mL/sec/cm3 0.000000 6 1 S06-03
545 Khe Hepatocellular tissue uptake rate 0.110399 mL/sec/cm3 0.000000 6 1 S06-03
546 kbh Biliary excretion rate 0.004727 mL/sec/cm3 0.000000 6 1 S06-03
547 E Liver extraction fraction 0.535569 0.000000 6 1 S06-03
548 Ktrans Hepatic plasma clearance 0.011793 mL/sec/cm3 0.000000 6 1 S06-03
549 H Hematocrit 0.418000 0.000000 6 1 S06-04
550 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-04
551 khe Hepatocellular uptake rate 0.020645 mL/sec/cm3 0.001435 6 1 S06-04
552 Th Hepatocellular mean transit time 173.413608 sec 12.984491 6 1 S06-04
553 Kbh Biliary tissue excretion rate 0.005767 mL/sec/cm3 0.000000 6 1 S06-04
554 Khe Hepatocellular tissue uptake rate 0.089759 mL/sec/cm3 0.000000 6 1 S06-04
555 kbh Biliary excretion rate 0.004440 mL/sec/cm3 0.000000 6 1 S06-04
556 E Liver extraction fraction 0.483893 0.000000 6 1 S06-04
557 Ktrans Hepatic plasma clearance 0.010655 mL/sec/cm3 0.000000 6 1 S06-04
558 H Hematocrit 0.418000 0.000000 6 1 S06-05
559 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-05
560 khe Hepatocellular uptake rate 0.019787 mL/sec/cm3 0.001499 6 1 S06-05
561 Th Hepatocellular mean transit time 170.731411 sec 13.947304 6 1 S06-05
562 Kbh Biliary tissue excretion rate 0.005857 mL/sec/cm3 0.000000 6 1 S06-05
563 Khe Hepatocellular tissue uptake rate 0.086031 mL/sec/cm3 0.000000 6 1 S06-05
564 kbh Biliary excretion rate 0.004510 mL/sec/cm3 0.000000 6 1 S06-05
565 E Liver extraction fraction 0.473306 0.000000 6 1 S06-05
566 Ktrans Hepatic plasma clearance 0.010422 mL/sec/cm3 0.000000 6 1 S06-05
567 H Hematocrit 0.418000 0.000000 6 1 S06-06
568 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 6 1 S06-06
569 khe Hepatocellular uptake rate 0.020815 mL/sec/cm3 0.001524 6 1 S06-06
570 Th Hepatocellular mean transit time 231.684464 sec 18.526224 6 1 S06-06
571 Kbh Biliary tissue excretion rate 0.004316 mL/sec/cm3 0.000000 6 1 S06-06
572 Khe Hepatocellular tissue uptake rate 0.090499 mL/sec/cm3 0.000000 6 1 S06-06
573 kbh Biliary excretion rate 0.003323 mL/sec/cm3 0.000000 6 1 S06-06
574 E Liver extraction fraction 0.485944 0.000000 6 1 S06-06
575 Ktrans Hepatic plasma clearance 0.010700 mL/sec/cm3 0.000000 6 1 S06-06
576 H Hematocrit 0.418000 0.000000 7 1 S07-01
577 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-01
578 khe Hepatocellular uptake rate 0.012259 mL/sec/cm3 0.000615 7 1 S07-01
579 Th Hepatocellular mean transit time 287.051267 sec 16.264662 7 1 S07-01
580 Kbh Biliary tissue excretion rate 0.003484 mL/sec/cm3 0.000000 7 1 S07-01
581 Khe Hepatocellular tissue uptake rate 0.053298 mL/sec/cm3 0.000000 7 1 S07-01
582 kbh Biliary excretion rate 0.002682 mL/sec/cm3 0.000000 7 1 S07-01
583 E Liver extraction fraction 0.357627 0.000000 7 1 S07-01
584 Ktrans Hepatic plasma clearance 0.007875 mL/sec/cm3 0.000000 7 1 S07-01
585 H Hematocrit 0.418000 0.000000 7 1 S07-02
586 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-02
587 khe Hepatocellular uptake rate 0.022070 mL/sec/cm3 0.002018 7 1 S07-02
588 Th Hepatocellular mean transit time 293.503375 sec 29.624750 7 1 S07-02
589 Kbh Biliary tissue excretion rate 0.003407 mL/sec/cm3 0.000000 7 1 S07-02
590 Khe Hepatocellular tissue uptake rate 0.095958 mL/sec/cm3 0.000000 7 1 S07-02
591 kbh Biliary excretion rate 0.002623 mL/sec/cm3 0.000000 7 1 S07-02
592 E Liver extraction fraction 0.500582 0.000000 7 1 S07-02
593 Ktrans Hepatic plasma clearance 0.011022 mL/sec/cm3 0.000000 7 1 S07-02
594 H Hematocrit 0.418000 0.000000 7 1 S07-03
595 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-03
596 khe Hepatocellular uptake rate 0.020564 mL/sec/cm3 0.002026 7 1 S07-03
597 Th Hepatocellular mean transit time 282.354635 sec 30.659355 7 1 S07-03
598 Kbh Biliary tissue excretion rate 0.003542 mL/sec/cm3 0.000000 7 1 S07-03
599 Khe Hepatocellular tissue uptake rate 0.089409 mL/sec/cm3 0.000000 7 1 S07-03
600 kbh Biliary excretion rate 0.002727 mL/sec/cm3 0.000000 7 1 S07-03
601 E Liver extraction fraction 0.482917 0.000000 7 1 S07-03
602 Ktrans Hepatic plasma clearance 0.010633 mL/sec/cm3 0.000000 7 1 S07-03
603 H Hematocrit 0.418000 0.000000 7 1 S07-04
604 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-04
605 khe Hepatocellular uptake rate 0.013127 mL/sec/cm3 0.000953 7 1 S07-04
606 Th Hepatocellular mean transit time 298.416370 sec 24.534799 7 1 S07-04
607 Kbh Biliary tissue excretion rate 0.003351 mL/sec/cm3 0.000000 7 1 S07-04
608 Khe Hepatocellular tissue uptake rate 0.057074 mL/sec/cm3 0.000000 7 1 S07-04
609 kbh Biliary excretion rate 0.002580 mL/sec/cm3 0.000000 7 1 S07-04
610 E Liver extraction fraction 0.373498 0.000000 7 1 S07-04
611 Ktrans Hepatic plasma clearance 0.008224 mL/sec/cm3 0.000000 7 1 S07-04
612 H Hematocrit 0.418000 0.000000 7 1 S07-05
613 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-05
614 khe Hepatocellular uptake rate 0.020795 mL/sec/cm3 0.002349 7 1 S07-05
615 Th Hepatocellular mean transit time 217.745080 sec 26.492837 7 1 S07-05
616 Kbh Biliary tissue excretion rate 0.004593 mL/sec/cm3 0.000000 7 1 S07-05
617 Khe Hepatocellular tissue uptake rate 0.090411 mL/sec/cm3 0.000000 7 1 S07-05
618 kbh Biliary excretion rate 0.003536 mL/sec/cm3 0.000000 7 1 S07-05
619 E Liver extraction fraction 0.485700 0.000000 7 1 S07-05
620 Ktrans Hepatic plasma clearance 0.010695 mL/sec/cm3 0.000000 7 1 S07-05
621 H Hematocrit 0.418000 0.000000 7 1 S07-06
622 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 7 1 S07-06
623 khe Hepatocellular uptake rate 0.022667 mL/sec/cm3 0.002503 7 1 S07-06
624 Th Hepatocellular mean transit time 257.860271 sec 30.914503 7 1 S07-06
625 Kbh Biliary tissue excretion rate 0.003878 mL/sec/cm3 0.000000 7 1 S07-06
626 Khe Hepatocellular tissue uptake rate 0.098553 mL/sec/cm3 0.000000 7 1 S07-06
627 kbh Biliary excretion rate 0.002986 mL/sec/cm3 0.000000 7 1 S07-06
628 E Liver extraction fraction 0.507254 0.000000 7 1 S07-06
629 Ktrans Hepatic plasma clearance 0.011169 mL/sec/cm3 0.000000 7 1 S07-06
630 H Hematocrit 0.418000 0.000000 8 1 S08-01
631 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-01
632 khe Hepatocellular uptake rate 0.029344 mL/sec/cm3 0.001970 8 1 S08-01
633 Th Hepatocellular mean transit time 408.262045 sec 31.838820 8 1 S08-01
634 Kbh Biliary tissue excretion rate 0.002449 mL/sec/cm3 0.000000 8 1 S08-01
635 Khe Hepatocellular tissue uptake rate 0.127585 mL/sec/cm3 0.000000 8 1 S08-01
636 kbh Biliary excretion rate 0.001886 mL/sec/cm3 0.000000 8 1 S08-01
637 E Liver extraction fraction 0.571310 0.000000 8 1 S08-01
638 Ktrans Hepatic plasma clearance 0.012580 mL/sec/cm3 0.000000 8 1 S08-01
639 H Hematocrit 0.418000 0.000000 8 1 S08-02
640 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-02
641 khe Hepatocellular uptake rate 0.027849 mL/sec/cm3 0.002515 8 1 S08-02
642 Th Hepatocellular mean transit time 269.048876 sec 26.131604 8 1 S08-02
643 Kbh Biliary tissue excretion rate 0.003717 mL/sec/cm3 0.000000 8 1 S08-02
644 Khe Hepatocellular tissue uptake rate 0.121082 mL/sec/cm3 0.000000 8 1 S08-02
645 kbh Biliary excretion rate 0.002862 mL/sec/cm3 0.000000 8 1 S08-02
646 E Liver extraction fraction 0.558453 0.000000 8 1 S08-02
647 Ktrans Hepatic plasma clearance 0.012297 mL/sec/cm3 0.000000 8 1 S08-02
648 H Hematocrit 0.418000 0.000000 8 1 S08-03
649 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-03
650 khe Hepatocellular uptake rate 0.019728 mL/sec/cm3 0.001371 8 1 S08-03
651 Th Hepatocellular mean transit time 383.872404 sec 31.160715 8 1 S08-03
652 Kbh Biliary tissue excretion rate 0.002605 mL/sec/cm3 0.000000 8 1 S08-03
653 Khe Hepatocellular tissue uptake rate 0.085774 mL/sec/cm3 0.000000 8 1 S08-03
654 kbh Biliary excretion rate 0.002006 mL/sec/cm3 0.000000 8 1 S08-03
655 E Liver extraction fraction 0.472562 0.000000 8 1 S08-03
656 Ktrans Hepatic plasma clearance 0.010405 mL/sec/cm3 0.000000 8 1 S08-03
657 H Hematocrit 0.418000 0.000000 8 1 S08-04
658 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-04
659 khe Hepatocellular uptake rate 0.018832 mL/sec/cm3 0.001177 8 1 S08-04
660 Th Hepatocellular mean transit time 435.387822 sec 33.054295 8 1 S08-04
661 Kbh Biliary tissue excretion rate 0.002297 mL/sec/cm3 0.000000 8 1 S08-04
662 Khe Hepatocellular tissue uptake rate 0.081878 mL/sec/cm3 0.000000 8 1 S08-04
663 kbh Biliary excretion rate 0.001769 mL/sec/cm3 0.000000 8 1 S08-04
664 E Liver extraction fraction 0.460991 0.000000 8 1 S08-04
665 Ktrans Hepatic plasma clearance 0.010151 mL/sec/cm3 0.000000 8 1 S08-04
666 H Hematocrit 0.418000 0.000000 8 1 S08-05
667 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-05
668 khe Hepatocellular uptake rate 0.025961 mL/sec/cm3 0.002111 8 1 S08-05
669 Th Hepatocellular mean transit time 262.092578 sec 22.959490 8 1 S08-05
670 Kbh Biliary tissue excretion rate 0.003815 mL/sec/cm3 0.000000 8 1 S08-05
671 Khe Hepatocellular tissue uptake rate 0.112874 mL/sec/cm3 0.000000 8 1 S08-05
672 kbh Biliary excretion rate 0.002938 mL/sec/cm3 0.000000 8 1 S08-05
673 E Liver extraction fraction 0.541079 0.000000 8 1 S08-05
674 Ktrans Hepatic plasma clearance 0.011914 mL/sec/cm3 0.000000 8 1 S08-05
675 H Hematocrit 0.418000 0.000000 8 1 S08-06
676 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 8 1 S08-06
677 khe Hepatocellular uptake rate 0.025441 mL/sec/cm3 0.002053 8 1 S08-06
678 Th Hepatocellular mean transit time 295.237391 sec 26.068654 8 1 S08-06
679 Kbh Biliary tissue excretion rate 0.003387 mL/sec/cm3 0.000000 8 1 S08-06
680 Khe Hepatocellular tissue uptake rate 0.110613 mL/sec/cm3 0.000000 8 1 S08-06
681 kbh Biliary excretion rate 0.002608 mL/sec/cm3 0.000000 8 1 S08-06
682 E Liver extraction fraction 0.536050 0.000000 8 1 S08-06
683 Ktrans Hepatic plasma clearance 0.011803 mL/sec/cm3 0.000000 8 1 S08-06
684 H Hematocrit 0.418000 0.000000 9 1 S09-01
685 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-01
686 khe Hepatocellular uptake rate 0.020030 mL/sec/cm3 0.000709 9 1 S09-01
687 Th Hepatocellular mean transit time 373.947283 sec 15.530816 9 1 S09-01
688 Kbh Biliary tissue excretion rate 0.002674 mL/sec/cm3 0.000000 9 1 S09-01
689 Khe Hepatocellular tissue uptake rate 0.087087 mL/sec/cm3 0.000000 9 1 S09-01
690 kbh Biliary excretion rate 0.002059 mL/sec/cm3 0.000000 9 1 S09-01
691 E Liver extraction fraction 0.476350 0.000000 9 1 S09-01
692 Ktrans Hepatic plasma clearance 0.010489 mL/sec/cm3 0.000000 9 1 S09-01
693 H Hematocrit 0.418000 0.000000 9 1 S09-02
694 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-02
695 khe Hepatocellular uptake rate 0.017119 mL/sec/cm3 0.001287 9 1 S09-02
696 Th Hepatocellular mean transit time 231.522778 sec 19.151147 9 1 S09-02
697 Kbh Biliary tissue excretion rate 0.004319 mL/sec/cm3 0.000000 9 1 S09-02
698 Khe Hepatocellular tissue uptake rate 0.074433 mL/sec/cm3 0.000000 9 1 S09-02
699 kbh Biliary excretion rate 0.003326 mL/sec/cm3 0.000000 9 1 S09-02
700 E Liver extraction fraction 0.437408 0.000000 9 1 S09-02
701 Ktrans Hepatic plasma clearance 0.009631 mL/sec/cm3 0.000000 9 1 S09-02
702 H Hematocrit 0.418000 0.000000 9 1 S09-03
703 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-03
704 khe Hepatocellular uptake rate 0.028307 mL/sec/cm3 0.002243 9 1 S09-03
705 Th Hepatocellular mean transit time 297.434220 sec 26.028315 9 1 S09-03
706 Kbh Biliary tissue excretion rate 0.003362 mL/sec/cm3 0.000000 9 1 S09-03
707 Khe Hepatocellular tissue uptake rate 0.123073 mL/sec/cm3 0.000000 9 1 S09-03
708 kbh Biliary excretion rate 0.002589 mL/sec/cm3 0.000000 9 1 S09-03
709 E Liver extraction fraction 0.562470 0.000000 9 1 S09-03
710 Ktrans Hepatic plasma clearance 0.012385 mL/sec/cm3 0.000000 9 1 S09-03
711 H Hematocrit 0.418000 0.000000 9 1 S09-04
712 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 9 1 S09-04
713 khe Hepatocellular uptake rate 0.031829 mL/sec/cm3 0.002277 9 1 S09-04
714 Th Hepatocellular mean transit time 276.696420 sec 21.511310 9 1 S09-04
715 Kbh Biliary tissue excretion rate 0.003614 mL/sec/cm3 0.000000 9 1 S09-04
716 Khe Hepatocellular tissue uptake rate 0.138388 mL/sec/cm3 0.000000 9 1 S09-04
717 kbh Biliary excretion rate 0.002783 mL/sec/cm3 0.000000 9 1 S09-04
718 E Liver extraction fraction 0.591092 0.000000 9 1 S09-04
719 Ktrans Hepatic plasma clearance 0.013015 mL/sec/cm3 0.000000 9 1 S09-04
720 H Hematocrit 0.418000 0.000000 10 1 S10-01
721 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-01
722 khe Hepatocellular uptake rate 0.032653 mL/sec/cm3 0.002459 10 1 S10-01
723 Th Hepatocellular mean transit time 204.095965 sec 16.306195 10 1 S10-01
724 Kbh Biliary tissue excretion rate 0.004900 mL/sec/cm3 0.000000 10 1 S10-01
725 Khe Hepatocellular tissue uptake rate 0.141969 mL/sec/cm3 0.000000 10 1 S10-01
726 kbh Biliary excretion rate 0.003773 mL/sec/cm3 0.000000 10 1 S10-01
727 E Liver extraction fraction 0.597252 0.000000 10 1 S10-01
728 Ktrans Hepatic plasma clearance 0.013151 mL/sec/cm3 0.000000 10 1 S10-01
729 H Hematocrit 0.418000 0.000000 10 1 S10-02
730 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-02
731 khe Hepatocellular uptake rate 0.025971 mL/sec/cm3 0.001777 10 1 S10-02
732 Th Hepatocellular mean transit time 260.964310 sec 19.500936 10 1 S10-02
733 Kbh Biliary tissue excretion rate 0.003832 mL/sec/cm3 0.000000 10 1 S10-02
734 Khe Hepatocellular tissue uptake rate 0.112917 mL/sec/cm3 0.000000 10 1 S10-02
735 kbh Biliary excretion rate 0.002951 mL/sec/cm3 0.000000 10 1 S10-02
736 E Liver extraction fraction 0.541175 0.000000 10 1 S10-02
737 Ktrans Hepatic plasma clearance 0.011916 mL/sec/cm3 0.000000 10 1 S10-02
738 H Hematocrit 0.418000 0.000000 10 1 S10-03
739 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-03
740 khe Hepatocellular uptake rate 0.036772 mL/sec/cm3 0.002993 10 1 S10-03
741 Th Hepatocellular mean transit time 192.094645 sec 16.432004 10 1 S10-03
742 Kbh Biliary tissue excretion rate 0.005206 mL/sec/cm3 0.000000 10 1 S10-03
743 Khe Hepatocellular tissue uptake rate 0.159880 mL/sec/cm3 0.000000 10 1 S10-03
744 kbh Biliary excretion rate 0.004008 mL/sec/cm3 0.000000 10 1 S10-03
745 E Liver extraction fraction 0.625472 0.000000 10 1 S10-03
746 Ktrans Hepatic plasma clearance 0.013772 mL/sec/cm3 0.000000 10 1 S10-03
747 H Hematocrit 0.418000 0.000000 10 1 S10-04
748 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-04
749 khe Hepatocellular uptake rate 0.034563 mL/sec/cm3 0.003415 10 1 S10-04
750 Th Hepatocellular mean transit time 221.220680 sec 23.197005 10 1 S10-04
751 Kbh Biliary tissue excretion rate 0.004520 mL/sec/cm3 0.000000 10 1 S10-04
752 Khe Hepatocellular tissue uptake rate 0.150275 mL/sec/cm3 0.000000 10 1 S10-04
753 kbh Biliary excretion rate 0.003481 mL/sec/cm3 0.000000 10 1 S10-04
754 E Liver extraction fraction 0.610850 0.000000 10 1 S10-04
755 Ktrans Hepatic plasma clearance 0.013450 mL/sec/cm3 0.000000 10 1 S10-04
756 H Hematocrit 0.418000 0.000000 10 1 S10-05
757 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-05
758 khe Hepatocellular uptake rate 0.032724 mL/sec/cm3 0.002464 10 1 S10-05
759 Th Hepatocellular mean transit time 203.321189 sec 16.233566 10 1 S10-05
760 Kbh Biliary tissue excretion rate 0.004918 mL/sec/cm3 0.000000 10 1 S10-05
761 Khe Hepatocellular tissue uptake rate 0.142280 mL/sec/cm3 0.000000 10 1 S10-05
762 kbh Biliary excretion rate 0.003787 mL/sec/cm3 0.000000 10 1 S10-05
763 E Liver extraction fraction 0.597778 0.000000 10 1 S10-05
764 Ktrans Hepatic plasma clearance 0.013162 mL/sec/cm3 0.000000 10 1 S10-05
765 H Hematocrit 0.418000 0.000000 10 1 S10-06
766 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 10 1 S10-06
767 khe Hepatocellular uptake rate 0.039966 mL/sec/cm3 0.002838 10 1 S10-06
768 Th Hepatocellular mean transit time 225.378400 sec 16.843082 10 1 S10-06
769 Kbh Biliary tissue excretion rate 0.004437 mL/sec/cm3 0.000000 10 1 S10-06
770 Khe Hepatocellular tissue uptake rate 0.173767 mL/sec/cm3 0.000000 10 1 S10-06
771 kbh Biliary excretion rate 0.003416 mL/sec/cm3 0.000000 10 1 S10-06
772 E Liver extraction fraction 0.644771 0.000000 10 1 S10-06
773 Ktrans Hepatic plasma clearance 0.014197 mL/sec/cm3 0.000000 10 1 S10-06
774 H Hematocrit 0.418000 0.000000 11 1 S11-01
775 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-01
776 khe Hepatocellular uptake rate 0.014012 mL/sec/cm3 0.000881 11 1 S11-01
777 Th Hepatocellular mean transit time 227.051874 sec 15.786653 11 1 S11-01
778 Kbh Biliary tissue excretion rate 0.004404 mL/sec/cm3 0.000000 11 1 S11-01
779 Khe Hepatocellular tissue uptake rate 0.060920 mL/sec/cm3 0.000000 11 1 S11-01
780 kbh Biliary excretion rate 0.003391 mL/sec/cm3 0.000000 11 1 S11-01
781 E Liver extraction fraction 0.388880 0.000000 11 1 S11-01
782 Ktrans Hepatic plasma clearance 0.008563 mL/sec/cm3 0.000000 11 1 S11-01
783 H Hematocrit 0.418000 0.000000 11 1 S11-02
784 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-02
785 khe Hepatocellular uptake rate 0.028364 mL/sec/cm3 0.001967 11 1 S11-02
786 Th Hepatocellular mean transit time 269.369316 sec 20.372041 11 1 S11-02
787 Kbh Biliary tissue excretion rate 0.003712 mL/sec/cm3 0.000000 11 1 S11-02
788 Khe Hepatocellular tissue uptake rate 0.123322 mL/sec/cm3 0.000000 11 1 S11-02
789 kbh Biliary excretion rate 0.002859 mL/sec/cm3 0.000000 11 1 S11-02
790 E Liver extraction fraction 0.562969 0.000000 11 1 S11-02
791 Ktrans Hepatic plasma clearance 0.012396 mL/sec/cm3 0.000000 11 1 S11-02
792 H Hematocrit 0.418000 0.000000 11 1 S11-03
793 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-03
794 khe Hepatocellular uptake rate 0.030036 mL/sec/cm3 0.002657 11 1 S11-03
795 Th Hepatocellular mean transit time 219.517315 sec 20.772082 11 1 S11-03
796 Kbh Biliary tissue excretion rate 0.004555 mL/sec/cm3 0.000000 11 1 S11-03
797 Khe Hepatocellular tissue uptake rate 0.130592 mL/sec/cm3 0.000000 11 1 S11-03
798 kbh Biliary excretion rate 0.003508 mL/sec/cm3 0.000000 11 1 S11-03
799 E Liver extraction fraction 0.577006 0.000000 11 1 S11-03
800 Ktrans Hepatic plasma clearance 0.012705 mL/sec/cm3 0.000000 11 1 S11-03
801 H Hematocrit 0.418000 0.000000 11 1 S11-04
802 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-04
803 khe Hepatocellular uptake rate 0.029084 mL/sec/cm3 0.002288 11 1 S11-04
804 Th Hepatocellular mean transit time 234.766701 sec 19.873939 11 1 S11-04
805 Kbh Biliary tissue excretion rate 0.004260 mL/sec/cm3 0.000000 11 1 S11-04
806 Khe Hepatocellular tissue uptake rate 0.126451 mL/sec/cm3 0.000000 11 1 S11-04
807 kbh Biliary excretion rate 0.003280 mL/sec/cm3 0.000000 11 1 S11-04
808 E Liver extraction fraction 0.569124 0.000000 11 1 S11-04
809 Ktrans Hepatic plasma clearance 0.012532 mL/sec/cm3 0.000000 11 1 S11-04
810 H Hematocrit 0.418000 0.000000 11 1 S11-05
811 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-05
812 khe Hepatocellular uptake rate 0.023826 mL/sec/cm3 0.001681 11 1 S11-05
813 Th Hepatocellular mean transit time 313.385810 sec 24.843092 11 1 S11-05
814 Kbh Biliary tissue excretion rate 0.003191 mL/sec/cm3 0.000000 11 1 S11-05
815 Khe Hepatocellular tissue uptake rate 0.103590 mL/sec/cm3 0.000000 11 1 S11-05
816 kbh Biliary excretion rate 0.002457 mL/sec/cm3 0.000000 11 1 S11-05
817 E Liver extraction fraction 0.519703 0.000000 11 1 S11-05
818 Ktrans Hepatic plasma clearance 0.011443 mL/sec/cm3 0.000000 11 1 S11-05
819 H Hematocrit 0.418000 0.000000 11 1 S11-06
820 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 11 1 S11-06
821 khe Hepatocellular uptake rate 0.029338 mL/sec/cm3 0.002007 11 1 S11-06
822 Th Hepatocellular mean transit time 264.579427 sec 19.666217 11 1 S11-06
823 Kbh Biliary tissue excretion rate 0.003780 mL/sec/cm3 0.000000 11 1 S11-06
824 Khe Hepatocellular tissue uptake rate 0.127557 mL/sec/cm3 0.000000 11 1 S11-06
825 kbh Biliary excretion rate 0.002910 mL/sec/cm3 0.000000 11 1 S11-06
826 E Liver extraction fraction 0.571256 0.000000 11 1 S11-06
827 Ktrans Hepatic plasma clearance 0.012578 mL/sec/cm3 0.000000 11 1 S11-06
828 H Hematocrit 0.418000 0.000000 12 1 S12-01
829 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-01
830 khe Hepatocellular uptake rate 0.030000 mL/sec/cm3 0.001981 12 1 S12-01
831 Th Hepatocellular mean transit time 326.139621 sec 23.676019 12 1 S12-01
832 Kbh Biliary tissue excretion rate 0.003066 mL/sec/cm3 0.000000 12 1 S12-01
833 Khe Hepatocellular tissue uptake rate 0.130435 mL/sec/cm3 0.000000 12 1 S12-01
834 kbh Biliary excretion rate 0.002361 mL/sec/cm3 0.000000 12 1 S12-01
835 E Liver extraction fraction 0.576713 0.000000 12 1 S12-01
836 Ktrans Hepatic plasma clearance 0.012699 mL/sec/cm3 0.000000 12 1 S12-01
837 H Hematocrit 0.418000 0.000000 12 1 S12-02
838 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-02
839 khe Hepatocellular uptake rate 0.027448 mL/sec/cm3 0.001948 12 1 S12-02
840 Th Hepatocellular mean transit time 262.269019 sec 19.984344 12 1 S12-02
841 Kbh Biliary tissue excretion rate 0.003813 mL/sec/cm3 0.000000 12 1 S12-02
842 Khe Hepatocellular tissue uptake rate 0.119340 mL/sec/cm3 0.000000 12 1 S12-02
843 kbh Biliary excretion rate 0.002936 mL/sec/cm3 0.000000 12 1 S12-02
844 E Liver extraction fraction 0.554877 0.000000 12 1 S12-02
845 Ktrans Hepatic plasma clearance 0.012218 mL/sec/cm3 0.000000 12 1 S12-02
846 H Hematocrit 0.418000 0.000000 12 1 S12-03
847 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-03
848 khe Hepatocellular uptake rate 0.030764 mL/sec/cm3 0.002113 12 1 S12-03
849 Th Hepatocellular mean transit time 261.478684 sec 19.132158 12 1 S12-03
850 Kbh Biliary tissue excretion rate 0.003824 mL/sec/cm3 0.000000 12 1 S12-03
851 Khe Hepatocellular tissue uptake rate 0.133755 mL/sec/cm3 0.000000 12 1 S12-03
852 kbh Biliary excretion rate 0.002945 mL/sec/cm3 0.000000 12 1 S12-03
853 E Liver extraction fraction 0.582837 0.000000 12 1 S12-03
854 Ktrans Hepatic plasma clearance 0.012833 mL/sec/cm3 0.000000 12 1 S12-03
855 H Hematocrit 0.418000 0.000000 12 1 S12-04
856 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 12 1 S12-04
857 khe Hepatocellular uptake rate 0.028471 mL/sec/cm3 0.001859 12 1 S12-04
858 Th Hepatocellular mean transit time 269.447999 sec 18.903053 12 1 S12-04
859 Kbh Biliary tissue excretion rate 0.003711 mL/sec/cm3 0.000000 12 1 S12-04
860 Khe Hepatocellular tissue uptake rate 0.123788 mL/sec/cm3 0.000000 12 1 S12-04
861 kbh Biliary excretion rate 0.002858 mL/sec/cm3 0.000000 12 1 S12-04
862 E Liver extraction fraction 0.563896 0.000000 12 1 S12-04
863 Ktrans Hepatic plasma clearance 0.012416 mL/sec/cm3 0.000000 12 1 S12-04
864 H Hematocrit 0.418000 0.000000 13 1 S13-01
865 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-01
866 khe Hepatocellular uptake rate 0.019085 mL/sec/cm3 0.002455 13 1 S13-01
867 Th Hepatocellular mean transit time 156.031562 sec 21.402089 13 1 S13-01
868 Kbh Biliary tissue excretion rate 0.006409 mL/sec/cm3 0.000000 13 1 S13-01
869 Khe Hepatocellular tissue uptake rate 0.082977 mL/sec/cm3 0.000000 13 1 S13-01
870 kbh Biliary excretion rate 0.004935 mL/sec/cm3 0.000000 13 1 S13-01
871 E Liver extraction fraction 0.464307 0.000000 13 1 S13-01
872 Ktrans Hepatic plasma clearance 0.010224 mL/sec/cm3 0.000000 13 1 S13-01
873 H Hematocrit 0.418000 0.000000 13 2 S13-01
874 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-01
875 khe Hepatocellular uptake rate 0.024808 mL/sec/cm3 0.001606 13 2 S13-01
876 Th Hepatocellular mean transit time 244.656111 sec 17.235264 13 2 S13-01
877 Kbh Biliary tissue excretion rate 0.004087 mL/sec/cm3 0.000000 13 2 S13-01
878 Khe Hepatocellular tissue uptake rate 0.107860 mL/sec/cm3 0.000000 13 2 S13-01
879 kbh Biliary excretion rate 0.003147 mL/sec/cm3 0.000000 13 2 S13-01
880 E Liver extraction fraction 0.529778 0.000000 13 2 S13-01
881 Ktrans Hepatic plasma clearance 0.011665 mL/sec/cm3 0.000000 13 2 S13-01
882 H Hematocrit 0.418000 0.000000 13 1 S13-02
883 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-02
884 khe Hepatocellular uptake rate 0.026554 mL/sec/cm3 0.002467 13 1 S13-02
885 Th Hepatocellular mean transit time 187.581317 sec 18.382557 13 1 S13-02
886 Kbh Biliary tissue excretion rate 0.005331 mL/sec/cm3 0.000000 13 1 S13-02
887 Khe Hepatocellular tissue uptake rate 0.115452 mL/sec/cm3 0.000000 13 1 S13-02
888 kbh Biliary excretion rate 0.004105 mL/sec/cm3 0.000000 13 1 S13-02
889 E Liver extraction fraction 0.546681 0.000000 13 1 S13-02
890 Ktrans Hepatic plasma clearance 0.012037 mL/sec/cm3 0.000000 13 1 S13-02
891 H Hematocrit 0.418000 0.000000 13 2 S13-02
892 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-02
893 khe Hepatocellular uptake rate 0.027595 mL/sec/cm3 0.001957 13 2 S13-02
894 Th Hepatocellular mean transit time 237.503247 sec 18.192700 13 2 S13-02
895 Kbh Biliary tissue excretion rate 0.004210 mL/sec/cm3 0.000000 13 2 S13-02
896 Khe Hepatocellular tissue uptake rate 0.119980 mL/sec/cm3 0.000000 13 2 S13-02
897 kbh Biliary excretion rate 0.003242 mL/sec/cm3 0.000000 13 2 S13-02
898 E Liver extraction fraction 0.556197 0.000000 13 2 S13-02
899 Ktrans Hepatic plasma clearance 0.012247 mL/sec/cm3 0.000000 13 2 S13-02
900 H Hematocrit 0.418000 0.000000 13 1 S13-03
901 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-03
902 khe Hepatocellular uptake rate 0.024377 mL/sec/cm3 0.002563 13 1 S13-03
903 Th Hepatocellular mean transit time 214.667832 sec 24.050896 13 1 S13-03
904 Kbh Biliary tissue excretion rate 0.004658 mL/sec/cm3 0.000000 13 1 S13-03
905 Khe Hepatocellular tissue uptake rate 0.105988 mL/sec/cm3 0.000000 13 1 S13-03
906 kbh Biliary excretion rate 0.003587 mL/sec/cm3 0.000000 13 1 S13-03
907 E Liver extraction fraction 0.525415 0.000000 13 1 S13-03
908 Ktrans Hepatic plasma clearance 0.011569 mL/sec/cm3 0.000000 13 1 S13-03
909 H Hematocrit 0.418000 0.000000 13 2 S13-03
910 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-03
911 khe Hepatocellular uptake rate 0.022180 mL/sec/cm3 0.001826 13 2 S13-03
912 Th Hepatocellular mean transit time 226.709014 sec 20.299682 13 2 S13-03
913 Kbh Biliary tissue excretion rate 0.004411 mL/sec/cm3 0.000000 13 2 S13-03
914 Khe Hepatocellular tissue uptake rate 0.096435 mL/sec/cm3 0.000000 13 2 S13-03
915 kbh Biliary excretion rate 0.003396 mL/sec/cm3 0.000000 13 2 S13-03
916 E Liver extraction fraction 0.501822 0.000000 13 2 S13-03
917 Ktrans Hepatic plasma clearance 0.011050 mL/sec/cm3 0.000000 13 2 S13-03
918 H Hematocrit 0.418000 0.000000 13 1 S13-04
919 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-04
920 khe Hepatocellular uptake rate 0.037584 mL/sec/cm3 0.002927 13 1 S13-04
921 Th Hepatocellular mean transit time 254.315529 sec 21.112256 13 1 S13-04
922 Kbh Biliary tissue excretion rate 0.003932 mL/sec/cm3 0.000000 13 1 S13-04
923 Khe Hepatocellular tissue uptake rate 0.163407 mL/sec/cm3 0.000000 13 1 S13-04
924 kbh Biliary excretion rate 0.003028 mL/sec/cm3 0.000000 13 1 S13-04
925 E Liver extraction fraction 0.630570 0.000000 13 1 S13-04
926 Ktrans Hepatic plasma clearance 0.013885 mL/sec/cm3 0.000000 13 1 S13-04
927 H Hematocrit 0.418000 0.000000 13 2 S13-04
928 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-04
929 khe Hepatocellular uptake rate 0.032488 mL/sec/cm3 0.003095 13 2 S13-04
930 Th Hepatocellular mean transit time 241.158572 sec 24.217476 13 2 S13-04
931 Kbh Biliary tissue excretion rate 0.004147 mL/sec/cm3 0.000000 13 2 S13-04
932 Khe Hepatocellular tissue uptake rate 0.141253 mL/sec/cm3 0.000000 13 2 S13-04
933 kbh Biliary excretion rate 0.003193 mL/sec/cm3 0.000000 13 2 S13-04
934 E Liver extraction fraction 0.596035 0.000000 13 2 S13-04
935 Ktrans Hepatic plasma clearance 0.013124 mL/sec/cm3 0.000000 13 2 S13-04
936 H Hematocrit 0.418000 0.000000 13 1 S13-05
937 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-05
938 khe Hepatocellular uptake rate 0.039824 mL/sec/cm3 0.004918 13 1 S13-05
939 Th Hepatocellular mean transit time 189.275595 sec 24.429376 13 1 S13-05
940 Kbh Biliary tissue excretion rate 0.005283 mL/sec/cm3 0.000000 13 1 S13-05
941 Khe Hepatocellular tissue uptake rate 0.173150 mL/sec/cm3 0.000000 13 1 S13-05
942 kbh Biliary excretion rate 0.004068 mL/sec/cm3 0.000000 13 1 S13-05
943 E Liver extraction fraction 0.643956 0.000000 13 1 S13-05
944 Ktrans Hepatic plasma clearance 0.014179 mL/sec/cm3 0.000000 13 1 S13-05
945 H Hematocrit 0.418000 0.000000 13 2 S13-05
946 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-05
947 khe Hepatocellular uptake rate 0.028822 mL/sec/cm3 0.002995 13 2 S13-05
948 Th Hepatocellular mean transit time 180.559714 sec 19.678171 13 2 S13-05
949 Kbh Biliary tissue excretion rate 0.005538 mL/sec/cm3 0.000000 13 2 S13-05
950 Khe Hepatocellular tissue uptake rate 0.125312 mL/sec/cm3 0.000000 13 2 S13-05
951 kbh Biliary excretion rate 0.004265 mL/sec/cm3 0.000000 13 2 S13-05
952 E Liver extraction fraction 0.566902 0.000000 13 2 S13-05
953 Ktrans Hepatic plasma clearance 0.012483 mL/sec/cm3 0.000000 13 2 S13-05
954 H Hematocrit 0.418000 0.000000 13 1 S13-06
955 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 1 S13-06
956 khe Hepatocellular uptake rate 0.037123 mL/sec/cm3 0.003325 13 1 S13-06
957 Th Hepatocellular mean transit time 204.034295 sec 19.236146 13 1 S13-06
958 Kbh Biliary tissue excretion rate 0.004901 mL/sec/cm3 0.000000 13 1 S13-06
959 Khe Hepatocellular tissue uptake rate 0.161406 mL/sec/cm3 0.000000 13 1 S13-06
960 kbh Biliary excretion rate 0.003774 mL/sec/cm3 0.000000 13 1 S13-06
961 E Liver extraction fraction 0.627695 0.000000 13 1 S13-06
962 Ktrans Hepatic plasma clearance 0.013821 mL/sec/cm3 0.000000 13 1 S13-06
963 H Hematocrit 0.418000 0.000000 13 2 S13-06
964 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 13 2 S13-06
965 khe Hepatocellular uptake rate 0.027368 mL/sec/cm3 0.001377 13 2 S13-06
966 Th Hepatocellular mean transit time 212.489355 sec 11.312341 13 2 S13-06
967 Kbh Biliary tissue excretion rate 0.004706 mL/sec/cm3 0.000000 13 2 S13-06
968 Khe Hepatocellular tissue uptake rate 0.118990 mL/sec/cm3 0.000000 13 2 S13-06
969 kbh Biliary excretion rate 0.003624 mL/sec/cm3 0.000000 13 2 S13-06
970 E Liver extraction fraction 0.554151 0.000000 13 2 S13-06
971 Ktrans Hepatic plasma clearance 0.012202 mL/sec/cm3 0.000000 13 2 S13-06
Plot individual results#
Now let’s calculate the average biomarker values per substudy for saline data only. For this exercise, let’s specify khe and kbh as the biomarker parameters that we are interested in. For each biomarker, we can plot the avergae biomarker values along with their 95% confidence intervals for each study group. We can also calculate an average ‘benchmark’ value across all study groups for each biomarker, and overlay these on the graphs to see whether the observed values lie within these ranges. red lines indicate the average benchmark value, while blue represents the upper and lower limits of the 95% confidence intervals (CIs) associated with these benchmarks.
# Customise plot settings
plt.rcParams['savefig.dpi'] = 300
plt.rcParams["axes.labelsize"] = 50
plt.rcParams["axes.titlesize"] = 50
plt.rcParams["axes.labelweight"] = 'bold'
plt.rcParams["axes.titleweight"] = 'bold'
plt.rcParams["font.weight"] = 'bold'
plt.rc('axes', linewidth=2)
plt.rc('xtick', labelsize=40)
plt.rc('ytick', labelsize=40)
plt.rcParams["lines.linewidth"] = 4
plt.rcParams['lines.markersize'] = 12
# Create list of biomarkers (parameters) of interest
params = ['khe', 'kbh']
# Extract data of interest, i.e., visit 1 data for parameters of interest
visitOneData = results.query('parameter in @params and visit==1')
# Get statistical summaries per parameter and study group
stat_summary = (visitOneData
.groupby(['parameter', 'study'])['value']
.agg(['mean']))
# Calculate benchmark values per parameter by averaging all study group averages
benchmarks = (stat_summary
.groupby(['parameter'])['mean']
.agg(['mean', 'sem']))
# Calculate the 95% confidence intervals for each parameter benchmark
benchmarks['CI95'] = (benchmarks['sem'].mul(1.96))
# Sort dataframes
visitOneData_sorted = visitOneData.sort_values(['parameter'], ascending=[False])
benchmarks_sorted = benchmarks.sort_values(['parameter'], ascending=[False])
# Plot distributions across all study groups per biomarker of interest
g = sns.catplot(data=visitOneData_sorted,
x='study',
y='value',
col='parameter',
kind='point',
capsize=0.2,
sharey=False,
linestyle='none',
height=14,
aspect=1.2,
color='k',
errorbar=('ci', 95))
g.set_titles("") # set custom subplot titles
# Set limits for y-axes
g.axes[0, 0].set(ylim=([0, 0.05]))
g.axes[0, 1].set(ylim=([0, 0.006]))
ylabels = ['$k_{he}$', '$k_{bh}$'] # define labels for y-axis
# Assign values from benchmarks dataframe to be
# used as horizontal lines to overlay on plots
means = benchmarks_sorted['mean']
lower_cis = means - benchmarks_sorted['CI95']
upper_cis = means + benchmarks_sorted['CI95']
# iterate through subplots to overlay y-labels and axis lines
for i in range(len(ylabels)):
g.axes[0, i].set_ylabel(f"{ylabels[i]} [mL/sec/cm3]")
g.axes[0, i].axhline(means.iloc[i], color='blue', ls=':')
g.axes[0, i].axhline(lower_cis.iloc[i], color='red', ls='--')
g.axes[0, i].axhline(upper_cis.iloc[i], color='red', ls='--')
plt.tight_layout()
plt.show()
# Choose the last image as a thumbnail for the gallery
# sphinx_gallery_thumbnail_number = -1
Total running time of the script: (0 minutes 24.502 seconds)