Note
Go to the end to download the full example code.
Preclinical - repeat dosing effects on liver function#
This example illustrates the use of Liver for fitting of signals
measured in liver. The use case is provided by the liver work package of the
TRISTAN project which develops imaging
biomarkers for drug safety assessment. The manuscript relating to this data
and analysis is currently in preparation.
The specific objective of the study was to investigate the potential of gadoxetate-enhanced DCE-MRI to study acute inhibition of hepatocyte transporters of drug-induced liver injury (DILI) causing drugs, and to study potential changes in transporter function after chronic dosing.
The study presented here measured gadoxetate uptake and excretion in healthy rats scanned after administration of vehicle and repetitive dosing regimes of either Rifampicin, Cyclosporine, or Bosentan. Studies were performed in preclinical MRI scanners at 3 different centers and 2 different field strengths.
Reference
Mikael Montelius, Steven Sourbron, Nicola Melillo, Daniel Scotcher, Aleksandra Galetin, Gunnar Schuetz, Claudia Green, Edvin Johansson, John C. Waterton, and Paul Hockings. Acute and chronic rifampicin effect on gadoxetate uptake in rats using gadoxetate DCE-MRI. Int Soc Mag Reson Med 2021; 2674.
Setup#
Model definition#
In order to avoid some repetition in this script, we define a function that returns a trained model for a single dataset.
The model uses a standardized, population-average input function and fits for only 2 parameters, fixing all other free parameters to typical values for this rat model:
def tristan_rat(roi, par, **kwargs):
# High-resolution time points for prediction
t = np.arange(0, np.amax(roi['time'])+0.5, 0.5)
# Standard input function
ca = dc.aif_tristan_rat(t, BAT=par['BAT'], duration=par['duration'])
# Liver model with population input function
model = dc.Liver(
# Input parameters
t = t,
ca = ca,
# Acquisition parameters
field_strength = par['field_strength'],
TR = par['TR'],
FA = par['FA'],
n0 = par['n0'],
# Configure as in the TRISTAN-rat study
config = 'TRISTAN-rat',
)
return model.train(roi['time'], roi['liver'], **kwargs)
Check model fit#
Before running the full analysis on all cases, lets illustrate the results by fitting the baseline visit for the first subject. We use maximum verbosity to get some feedback about the iterations:
Iteration Total nfev Cost Cost reduction Step norm Optimality
0 1 1.0128e+09 5.37e+10
1 3 8.9347e+08 1.19e+08 3.97e+02 6.21e+10
2 4 5.8888e+08 3.05e+08 7.01e+02 2.48e+11
3 5 4.1876e+08 1.70e+08 3.74e+01 1.80e+10
4 6 3.0475e+08 1.14e+08 3.64e+02 1.93e+11
5 7 4.3438e+07 2.61e+08 5.63e+01 3.92e+10
6 8 2.3882e+07 1.96e+07 1.63e+01 1.94e+07
7 9 2.3877e+07 4.84e+03 7.87e-01 3.92e+06
8 10 2.3877e+07 3.31e-01 4.72e-03 7.02e+02
`xtol` termination condition is satisfied.
Function evaluations 10, initial cost 1.0128e+09, final cost 2.3877e+07, first-order optimality 7.02e+02.
Plot the results to check that the model has fitted the data:
Print the measured model parameters and any derived parameters and check that standard deviations of measured parameters are small relative to the value, indicating that the parameters are measured reliably:
model.print_params(round_to=3)
--------------------------------
Free parameters with their stdev
--------------------------------
Hepatocellular uptake rate (khe): 0.011 (0.0) mL/sec/cm3
Hepatocellular mean transit time (Th): 260.882 (10.419) sec
----------------------------
Fixed and derived parameters
----------------------------
Hematocrit (H): 0.418
Liver extracellular volume fraction (ve): 0.23 mL/cm3
Biliary tissue excretion rate (Kbh): 0.004 mL/sec/cm3
Hepatocellular tissue uptake rate (Khe): 0.049 mL/sec/cm3
Biliary excretion rate (kbh): 0.003 mL/sec/cm3
Liver extraction fraction (E): 0.34
Hepatic plasma clearance (Ktrans): 0.007 mL/sec/cm3
Fit all data#
Now that we have illustrated an individual result in some detail, we proceed with fitting all the data. Results are stored in a dataframe in long format:
results = []
# Loop over all datasets
for subj in rois.keys():
for visit in rois[subj].keys():
roi = rois[subj][visit]
par = pars[subj][visit]
# Generate a trained model
model = tristan_rat(roi, par, xtol=1e-3)
# Export fitted parameters as lists
rows = model.export_params(type='list')
# Add study, visit and subject info
rows = [row + [par['study'], par['visit'], subj] for row in rows]
# Add to the list of all results
results += rows
# Combine all results into a single dataframe.
cols = ['parameter', 'name', 'value', 'unit', 'stdev', 'study',
'visit', 'subject']
results = pd.DataFrame(results, columns=cols)
# Print all results
print(results.to_string())
parameter name value unit stdev study visit subject
0 H Hematocrit 0.418000 0.000000 1 3 S01-10
1 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-10
2 khe Hepatocellular uptake rate 0.011360 mL/sec/cm3 0.000423 1 3 S01-10
3 Th Hepatocellular mean transit time 260.881888 sec 10.418663 1 3 S01-10
4 Kbh Biliary tissue excretion rate 0.003833 mL/sec/cm3 0.000000 1 3 S01-10
5 Khe Hepatocellular tissue uptake rate 0.049393 mL/sec/cm3 0.000000 1 3 S01-10
6 kbh Biliary excretion rate 0.002952 mL/sec/cm3 0.000000 1 3 S01-10
7 E Liver extraction fraction 0.340343 0.000000 1 3 S01-10
8 Ktrans Hepatic plasma clearance 0.007494 mL/sec/cm3 0.000000 1 3 S01-10
9 H Hematocrit 0.418000 0.000000 1 4 S01-10
10 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-10
11 khe Hepatocellular uptake rate 0.010694 mL/sec/cm3 0.000376 1 4 S01-10
12 Th Hepatocellular mean transit time 366.054509 sec 14.497231 1 4 S01-10
13 Kbh Biliary tissue excretion rate 0.002732 mL/sec/cm3 0.000000 1 4 S01-10
14 Khe Hepatocellular tissue uptake rate 0.046495 mL/sec/cm3 0.000000 1 4 S01-10
15 kbh Biliary excretion rate 0.002104 mL/sec/cm3 0.000000 1 4 S01-10
16 E Liver extraction fraction 0.326900 0.000000 1 4 S01-10
17 Ktrans Hepatic plasma clearance 0.007198 mL/sec/cm3 0.000000 1 4 S01-10
18 H Hematocrit 0.418000 0.000000 1 1 S01-11
19 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-11
20 khe Hepatocellular uptake rate 0.013929 mL/sec/cm3 0.000628 1 1 S01-11
21 Th Hepatocellular mean transit time 424.375002 sec 22.004551 1 1 S01-11
22 Kbh Biliary tissue excretion rate 0.002356 mL/sec/cm3 0.000000 1 1 S01-11
23 Khe Hepatocellular tissue uptake rate 0.060561 mL/sec/cm3 0.000000 1 1 S01-11
24 kbh Biliary excretion rate 0.001814 mL/sec/cm3 0.000000 1 1 S01-11
25 E Liver extraction fraction 0.387479 0.000000 1 1 S01-11
26 Ktrans Hepatic plasma clearance 0.008532 mL/sec/cm3 0.000000 1 1 S01-11
27 H Hematocrit 0.418000 0.000000 1 2 S01-11
28 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-11
29 khe Hepatocellular uptake rate 0.001648 mL/sec/cm3 0.000185 1 2 S01-11
30 Th Hepatocellular mean transit time 2487.727225 sec 1055.364828 1 2 S01-11
31 Kbh Biliary tissue excretion rate 0.000402 mL/sec/cm3 0.000000 1 2 S01-11
32 Khe Hepatocellular tissue uptake rate 0.007164 mL/sec/cm3 0.000000 1 2 S01-11
33 kbh Biliary excretion rate 0.000310 mL/sec/cm3 0.000000 1 2 S01-11
34 E Liver extraction fraction 0.069620 0.000000 1 2 S01-11
35 Ktrans Hepatic plasma clearance 0.001533 mL/sec/cm3 0.000000 1 2 S01-11
36 H Hematocrit 0.418000 0.000000 1 3 S01-11
37 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-11
38 khe Hepatocellular uptake rate 0.002163 mL/sec/cm3 0.000281 1 3 S01-11
39 Th Hepatocellular mean transit time 965.450684 sec 224.974883 1 3 S01-11
40 Kbh Biliary tissue excretion rate 0.001036 mL/sec/cm3 0.000000 1 3 S01-11
41 Khe Hepatocellular tissue uptake rate 0.009402 mL/sec/cm3 0.000000 1 3 S01-11
42 kbh Biliary excretion rate 0.000798 mL/sec/cm3 0.000000 1 3 S01-11
43 E Liver extraction fraction 0.089429 0.000000 1 3 S01-11
44 Ktrans Hepatic plasma clearance 0.001969 mL/sec/cm3 0.000000 1 3 S01-11
45 H Hematocrit 0.418000 0.000000 1 4 S01-11
46 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-11
47 khe Hepatocellular uptake rate 0.004936 mL/sec/cm3 0.000208 1 4 S01-11
48 Th Hepatocellular mean transit time 596.073557 sec 34.084226 1 4 S01-11
49 Kbh Biliary tissue excretion rate 0.001678 mL/sec/cm3 0.000000 1 4 S01-11
50 Khe Hepatocellular tissue uptake rate 0.021463 mL/sec/cm3 0.000000 1 4 S01-11
51 kbh Biliary excretion rate 0.001292 mL/sec/cm3 0.000000 1 4 S01-11
52 E Liver extraction fraction 0.183132 0.000000 1 4 S01-11
53 Ktrans Hepatic plasma clearance 0.004032 mL/sec/cm3 0.000000 1 4 S01-11
54 H Hematocrit 0.418000 0.000000 1 1 S01-12
55 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-12
56 khe Hepatocellular uptake rate 0.014488 mL/sec/cm3 0.000771 1 1 S01-12
57 Th Hepatocellular mean transit time 417.269572 sec 25.326947 1 1 S01-12
58 Kbh Biliary tissue excretion rate 0.002397 mL/sec/cm3 0.000000 1 1 S01-12
59 Khe Hepatocellular tissue uptake rate 0.062990 mL/sec/cm3 0.000000 1 1 S01-12
60 kbh Biliary excretion rate 0.001845 mL/sec/cm3 0.000000 1 1 S01-12
61 E Liver extraction fraction 0.396851 0.000000 1 1 S01-12
62 Ktrans Hepatic plasma clearance 0.008738 mL/sec/cm3 0.000000 1 1 S01-12
63 H Hematocrit 0.418000 0.000000 1 2 S01-12
64 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-12
65 khe Hepatocellular uptake rate 0.014446 mL/sec/cm3 0.000451 1 2 S01-12
66 Th Hepatocellular mean transit time 337.211463 sec 11.461603 1 2 S01-12
67 Kbh Biliary tissue excretion rate 0.002965 mL/sec/cm3 0.000000 1 2 S01-12
68 Khe Hepatocellular tissue uptake rate 0.062808 mL/sec/cm3 0.000000 1 2 S01-12
69 kbh Biliary excretion rate 0.002283 mL/sec/cm3 0.000000 1 2 S01-12
70 E Liver extraction fraction 0.396158 0.000000 1 2 S01-12
71 Ktrans Hepatic plasma clearance 0.008723 mL/sec/cm3 0.000000 1 2 S01-12
72 H Hematocrit 0.418000 0.000000 1 3 S01-12
73 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-12
74 khe Hepatocellular uptake rate 0.011003 mL/sec/cm3 0.000370 1 3 S01-12
75 Th Hepatocellular mean transit time 431.927755 sec 17.035747 1 3 S01-12
76 Kbh Biliary tissue excretion rate 0.002315 mL/sec/cm3 0.000000 1 3 S01-12
77 Khe Hepatocellular tissue uptake rate 0.047839 mL/sec/cm3 0.000000 1 3 S01-12
78 kbh Biliary excretion rate 0.001783 mL/sec/cm3 0.000000 1 3 S01-12
79 E Liver extraction fraction 0.333203 0.000000 1 3 S01-12
80 Ktrans Hepatic plasma clearance 0.007337 mL/sec/cm3 0.000000 1 3 S01-12
81 H Hematocrit 0.418000 0.000000 1 4 S01-12
82 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-12
83 khe Hepatocellular uptake rate 0.013862 mL/sec/cm3 0.000475 1 4 S01-12
84 Th Hepatocellular mean transit time 466.547133 sec 18.929658 1 4 S01-12
85 Kbh Biliary tissue excretion rate 0.002143 mL/sec/cm3 0.000000 1 4 S01-12
86 Khe Hepatocellular tissue uptake rate 0.060268 mL/sec/cm3 0.000000 1 4 S01-12
87 kbh Biliary excretion rate 0.001650 mL/sec/cm3 0.000000 1 4 S01-12
88 E Liver extraction fraction 0.386328 0.000000 1 4 S01-12
89 Ktrans Hepatic plasma clearance 0.008507 mL/sec/cm3 0.000000 1 4 S01-12
90 H Hematocrit 0.418000 0.000000 1 1 S01-01
91 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-01
92 khe Hepatocellular uptake rate 0.009421 mL/sec/cm3 0.000282 1 1 S01-01
93 Th Hepatocellular mean transit time 455.976198 sec 16.359730 1 1 S01-01
94 Kbh Biliary tissue excretion rate 0.002193 mL/sec/cm3 0.000000 1 1 S01-01
95 Khe Hepatocellular tissue uptake rate 0.040961 mL/sec/cm3 0.000000 1 1 S01-01
96 kbh Biliary excretion rate 0.001689 mL/sec/cm3 0.000000 1 1 S01-01
97 E Liver extraction fraction 0.299652 0.000000 1 1 S01-01
98 Ktrans Hepatic plasma clearance 0.006598 mL/sec/cm3 0.000000 1 1 S01-01
99 H Hematocrit 0.418000 0.000000 1 2 S01-01
100 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-01
101 khe Hepatocellular uptake rate 0.004239 mL/sec/cm3 0.000210 1 2 S01-01
102 Th Hepatocellular mean transit time 701.069187 sec 51.108464 1 2 S01-01
103 Kbh Biliary tissue excretion rate 0.001426 mL/sec/cm3 0.000000 1 2 S01-01
104 Khe Hepatocellular tissue uptake rate 0.018431 mL/sec/cm3 0.000000 1 2 S01-01
105 kbh Biliary excretion rate 0.001098 mL/sec/cm3 0.000000 1 2 S01-01
106 E Liver extraction fraction 0.161437 0.000000 1 2 S01-01
107 Ktrans Hepatic plasma clearance 0.003555 mL/sec/cm3 0.000000 1 2 S01-01
108 H Hematocrit 0.418000 0.000000 1 3 S01-01
109 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-01
110 khe Hepatocellular uptake rate 0.008431 mL/sec/cm3 0.000488 1 3 S01-01
111 Th Hepatocellular mean transit time 313.419030 sec 21.175651 1 3 S01-01
112 Kbh Biliary tissue excretion rate 0.003191 mL/sec/cm3 0.000000 1 3 S01-01
113 Khe Hepatocellular tissue uptake rate 0.036658 mL/sec/cm3 0.000000 1 3 S01-01
114 kbh Biliary excretion rate 0.002457 mL/sec/cm3 0.000000 1 3 S01-01
115 E Liver extraction fraction 0.276886 0.000000 1 3 S01-01
116 Ktrans Hepatic plasma clearance 0.006097 mL/sec/cm3 0.000000 1 3 S01-01
117 H Hematocrit 0.418000 0.000000 1 4 S01-01
118 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-01
119 khe Hepatocellular uptake rate 0.014041 mL/sec/cm3 0.000899 1 4 S01-01
120 Th Hepatocellular mean transit time 384.897687 sec 27.614715 1 4 S01-01
121 Kbh Biliary tissue excretion rate 0.002598 mL/sec/cm3 0.000000 1 4 S01-01
122 Khe Hepatocellular tissue uptake rate 0.061047 mL/sec/cm3 0.000000 1 4 S01-01
123 kbh Biliary excretion rate 0.002001 mL/sec/cm3 0.000000 1 4 S01-01
124 E Liver extraction fraction 0.389377 0.000000 1 4 S01-01
125 Ktrans Hepatic plasma clearance 0.008574 mL/sec/cm3 0.000000 1 4 S01-01
126 H Hematocrit 0.418000 0.000000 1 1 S01-02
127 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-02
128 khe Hepatocellular uptake rate 0.011729 mL/sec/cm3 0.000527 1 1 S01-02
129 Th Hepatocellular mean transit time 484.725752 sec 26.380592 1 1 S01-02
130 Kbh Biliary tissue excretion rate 0.002063 mL/sec/cm3 0.000000 1 1 S01-02
131 Khe Hepatocellular tissue uptake rate 0.050996 mL/sec/cm3 0.000000 1 1 S01-02
132 kbh Biliary excretion rate 0.001589 mL/sec/cm3 0.000000 1 1 S01-02
133 E Liver extraction fraction 0.347546 0.000000 1 1 S01-02
134 Ktrans Hepatic plasma clearance 0.007653 mL/sec/cm3 0.000000 1 1 S01-02
135 H Hematocrit 0.418000 0.000000 1 2 S01-02
136 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-02
137 khe Hepatocellular uptake rate 0.003668 mL/sec/cm3 0.000227 1 2 S01-02
138 Th Hepatocellular mean transit time 1054.167547 sec 124.051836 1 2 S01-02
139 Kbh Biliary tissue excretion rate 0.000949 mL/sec/cm3 0.000000 1 2 S01-02
140 Khe Hepatocellular tissue uptake rate 0.015949 mL/sec/cm3 0.000000 1 2 S01-02
141 kbh Biliary excretion rate 0.000730 mL/sec/cm3 0.000000 1 2 S01-02
142 E Liver extraction fraction 0.142806 0.000000 1 2 S01-02
143 Ktrans Hepatic plasma clearance 0.003144 mL/sec/cm3 0.000000 1 2 S01-02
144 H Hematocrit 0.418000 0.000000 1 3 S01-02
145 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-02
146 khe Hepatocellular uptake rate 0.004694 mL/sec/cm3 0.000381 1 3 S01-02
147 Th Hepatocellular mean transit time 697.642779 sec 83.085664 1 3 S01-02
148 Kbh Biliary tissue excretion rate 0.001433 mL/sec/cm3 0.000000 1 3 S01-02
149 Khe Hepatocellular tissue uptake rate 0.020409 mL/sec/cm3 0.000000 1 3 S01-02
150 kbh Biliary excretion rate 0.001104 mL/sec/cm3 0.000000 1 3 S01-02
151 E Liver extraction fraction 0.175724 0.000000 1 3 S01-02
152 Ktrans Hepatic plasma clearance 0.003869 mL/sec/cm3 0.000000 1 3 S01-02
153 H Hematocrit 0.418000 0.000000 1 4 S01-02
154 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-02
155 khe Hepatocellular uptake rate 0.015398 mL/sec/cm3 0.000560 1 4 S01-02
156 Th Hepatocellular mean transit time 315.509802 sec 12.316806 1 4 S01-02
157 Kbh Biliary tissue excretion rate 0.003169 mL/sec/cm3 0.000000 1 4 S01-02
158 Khe Hepatocellular tissue uptake rate 0.066947 mL/sec/cm3 0.000000 1 4 S01-02
159 kbh Biliary excretion rate 0.002440 mL/sec/cm3 0.000000 1 4 S01-02
160 E Liver extraction fraction 0.411520 0.000000 1 4 S01-02
161 Ktrans Hepatic plasma clearance 0.009061 mL/sec/cm3 0.000000 1 4 S01-02
162 H Hematocrit 0.418000 0.000000 1 1 S01-03
163 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-03
164 khe Hepatocellular uptake rate 0.019519 mL/sec/cm3 0.000883 1 1 S01-03
165 Th Hepatocellular mean transit time 312.731644 sec 14.896586 1 1 S01-03
166 Kbh Biliary tissue excretion rate 0.003198 mL/sec/cm3 0.000000 1 1 S01-03
167 Khe Hepatocellular tissue uptake rate 0.084863 mL/sec/cm3 0.000000 1 1 S01-03
168 kbh Biliary excretion rate 0.002462 mL/sec/cm3 0.000000 1 1 S01-03
169 E Liver extraction fraction 0.469901 0.000000 1 1 S01-03
170 Ktrans Hepatic plasma clearance 0.010347 mL/sec/cm3 0.000000 1 1 S01-03
171 H Hematocrit 0.418000 0.000000 1 2 S01-03
172 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-03
173 khe Hepatocellular uptake rate 0.015384 mL/sec/cm3 0.000736 1 2 S01-03
174 Th Hepatocellular mean transit time 327.292492 sec 16.897858 1 2 S01-03
175 Kbh Biliary tissue excretion rate 0.003055 mL/sec/cm3 0.000000 1 2 S01-03
176 Khe Hepatocellular tissue uptake rate 0.066885 mL/sec/cm3 0.000000 1 2 S01-03
177 kbh Biliary excretion rate 0.002353 mL/sec/cm3 0.000000 1 2 S01-03
178 E Liver extraction fraction 0.411299 0.000000 1 2 S01-03
179 Ktrans Hepatic plasma clearance 0.009056 mL/sec/cm3 0.000000 1 2 S01-03
180 H Hematocrit 0.418000 0.000000 1 3 S01-03
181 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-03
182 khe Hepatocellular uptake rate 0.012785 mL/sec/cm3 0.000771 1 3 S01-03
183 Th Hepatocellular mean transit time 395.362741 sec 27.063476 1 3 S01-03
184 Kbh Biliary tissue excretion rate 0.002529 mL/sec/cm3 0.000000 1 3 S01-03
185 Khe Hepatocellular tissue uptake rate 0.055588 mL/sec/cm3 0.000000 1 3 S01-03
186 kbh Biliary excretion rate 0.001948 mL/sec/cm3 0.000000 1 3 S01-03
187 E Liver extraction fraction 0.367347 0.000000 1 3 S01-03
188 Ktrans Hepatic plasma clearance 0.008089 mL/sec/cm3 0.000000 1 3 S01-03
189 H Hematocrit 0.418000 0.000000 1 4 S01-03
190 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-03
191 khe Hepatocellular uptake rate 0.015981 mL/sec/cm3 0.000860 1 4 S01-03
192 Th Hepatocellular mean transit time 348.756416 sec 20.418697 1 4 S01-03
193 Kbh Biliary tissue excretion rate 0.002867 mL/sec/cm3 0.000000 1 4 S01-03
194 Khe Hepatocellular tissue uptake rate 0.069483 mL/sec/cm3 0.000000 1 4 S01-03
195 kbh Biliary excretion rate 0.002208 mL/sec/cm3 0.000000 1 4 S01-03
196 E Liver extraction fraction 0.420553 0.000000 1 4 S01-03
197 Ktrans Hepatic plasma clearance 0.009260 mL/sec/cm3 0.000000 1 4 S01-03
198 H Hematocrit 0.418000 0.000000 1 1 S01-04
199 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-04
200 khe Hepatocellular uptake rate 0.002570 mL/sec/cm3 0.000264 1 1 S01-04
201 Th Hepatocellular mean transit time 427.138764 sec 53.709765 1 1 S01-04
202 Kbh Biliary tissue excretion rate 0.002341 mL/sec/cm3 0.000000 1 1 S01-04
203 Khe Hepatocellular tissue uptake rate 0.011172 mL/sec/cm3 0.000000 1 1 S01-04
204 kbh Biliary excretion rate 0.001803 mL/sec/cm3 0.000000 1 1 S01-04
205 E Liver extraction fraction 0.104504 0.000000 1 1 S01-04
206 Ktrans Hepatic plasma clearance 0.002301 mL/sec/cm3 0.000000 1 1 S01-04
207 H Hematocrit 0.418000 0.000000 1 2 S01-04
208 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-04
209 khe Hepatocellular uptake rate 0.004742 mL/sec/cm3 0.000301 1 2 S01-04
210 Th Hepatocellular mean transit time 510.073394 sec 41.386830 1 2 S01-04
211 Kbh Biliary tissue excretion rate 0.001961 mL/sec/cm3 0.000000 1 2 S01-04
212 Khe Hepatocellular tissue uptake rate 0.020618 mL/sec/cm3 0.000000 1 2 S01-04
213 kbh Biliary excretion rate 0.001510 mL/sec/cm3 0.000000 1 2 S01-04
214 E Liver extraction fraction 0.177206 0.000000 1 2 S01-04
215 Ktrans Hepatic plasma clearance 0.003902 mL/sec/cm3 0.000000 1 2 S01-04
216 H Hematocrit 0.418000 0.000000 1 3 S01-04
217 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-04
218 khe Hepatocellular uptake rate 0.014605 mL/sec/cm3 0.000652 1 3 S01-04
219 Th Hepatocellular mean transit time 280.643774 sec 13.311467 1 3 S01-04
220 Kbh Biliary tissue excretion rate 0.003563 mL/sec/cm3 0.000000 1 3 S01-04
221 Khe Hepatocellular tissue uptake rate 0.063501 mL/sec/cm3 0.000000 1 3 S01-04
222 kbh Biliary excretion rate 0.002744 mL/sec/cm3 0.000000 1 3 S01-04
223 E Liver extraction fraction 0.398786 0.000000 1 3 S01-04
224 Ktrans Hepatic plasma clearance 0.008781 mL/sec/cm3 0.000000 1 3 S01-04
225 H Hematocrit 0.418000 0.000000 1 4 S01-04
226 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-04
227 khe Hepatocellular uptake rate 0.004105 mL/sec/cm3 0.000335 1 4 S01-04
228 Th Hepatocellular mean transit time 389.894552 sec 37.662703 1 4 S01-04
229 Kbh Biliary tissue excretion rate 0.002565 mL/sec/cm3 0.000000 1 4 S01-04
230 Khe Hepatocellular tissue uptake rate 0.017849 mL/sec/cm3 0.000000 1 4 S01-04
231 kbh Biliary excretion rate 0.001975 mL/sec/cm3 0.000000 1 4 S01-04
232 E Liver extraction fraction 0.157147 0.000000 1 4 S01-04
233 Ktrans Hepatic plasma clearance 0.003460 mL/sec/cm3 0.000000 1 4 S01-04
234 H Hematocrit 0.418000 0.000000 1 1 S01-05
235 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-05
236 khe Hepatocellular uptake rate 0.011727 mL/sec/cm3 0.000566 1 1 S01-05
237 Th Hepatocellular mean transit time 445.224064 sec 25.319526 1 1 S01-05
238 Kbh Biliary tissue excretion rate 0.002246 mL/sec/cm3 0.000000 1 1 S01-05
239 Khe Hepatocellular tissue uptake rate 0.050986 mL/sec/cm3 0.000000 1 1 S01-05
240 kbh Biliary excretion rate 0.001729 mL/sec/cm3 0.000000 1 1 S01-05
241 E Liver extraction fraction 0.347505 0.000000 1 1 S01-05
242 Ktrans Hepatic plasma clearance 0.007652 mL/sec/cm3 0.000000 1 1 S01-05
243 H Hematocrit 0.418000 0.000000 1 2 S01-05
244 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-05
245 khe Hepatocellular uptake rate 0.002716 mL/sec/cm3 0.000258 1 2 S01-05
246 Th Hepatocellular mean transit time 1419.978564 sec 318.812190 1 2 S01-05
247 Kbh Biliary tissue excretion rate 0.000704 mL/sec/cm3 0.000000 1 2 S01-05
248 Khe Hepatocellular tissue uptake rate 0.011807 mL/sec/cm3 0.000000 1 2 S01-05
249 kbh Biliary excretion rate 0.000542 mL/sec/cm3 0.000000 1 2 S01-05
250 E Liver extraction fraction 0.109792 0.000000 1 2 S01-05
251 Ktrans Hepatic plasma clearance 0.002418 mL/sec/cm3 0.000000 1 2 S01-05
252 H Hematocrit 0.418000 0.000000 1 3 S01-05
253 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-05
254 khe Hepatocellular uptake rate 0.009439 mL/sec/cm3 0.000286 1 3 S01-05
255 Th Hepatocellular mean transit time 429.890843 sec 15.354736 1 3 S01-05
256 Kbh Biliary tissue excretion rate 0.002326 mL/sec/cm3 0.000000 1 3 S01-05
257 Khe Hepatocellular tissue uptake rate 0.041041 mL/sec/cm3 0.000000 1 3 S01-05
258 kbh Biliary excretion rate 0.001791 mL/sec/cm3 0.000000 1 3 S01-05
259 E Liver extraction fraction 0.300061 0.000000 1 3 S01-05
260 Ktrans Hepatic plasma clearance 0.006607 mL/sec/cm3 0.000000 1 3 S01-05
261 H Hematocrit 0.418000 0.000000 1 4 S01-05
262 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-05
263 khe Hepatocellular uptake rate 0.015926 mL/sec/cm3 0.000838 1 4 S01-05
264 Th Hepatocellular mean transit time 372.829327 sec 21.645639 1 4 S01-05
265 Kbh Biliary tissue excretion rate 0.002682 mL/sec/cm3 0.000000 1 4 S01-05
266 Khe Hepatocellular tissue uptake rate 0.069246 mL/sec/cm3 0.000000 1 4 S01-05
267 kbh Biliary excretion rate 0.002065 mL/sec/cm3 0.000000 1 4 S01-05
268 E Liver extraction fraction 0.419720 0.000000 1 4 S01-05
269 Ktrans Hepatic plasma clearance 0.009242 mL/sec/cm3 0.000000 1 4 S01-05
270 H Hematocrit 0.418000 0.000000 1 1 S01-06
271 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-06
272 khe Hepatocellular uptake rate 0.018883 mL/sec/cm3 0.000931 1 1 S01-06
273 Th Hepatocellular mean transit time 249.868614 sec 12.730263 1 1 S01-06
274 Kbh Biliary tissue excretion rate 0.004002 mL/sec/cm3 0.000000 1 1 S01-06
275 Khe Hepatocellular tissue uptake rate 0.082101 mL/sec/cm3 0.000000 1 1 S01-06
276 kbh Biliary excretion rate 0.003082 mL/sec/cm3 0.000000 1 1 S01-06
277 E Liver extraction fraction 0.461667 0.000000 1 1 S01-06
278 Ktrans Hepatic plasma clearance 0.010165 mL/sec/cm3 0.000000 1 1 S01-06
279 H Hematocrit 0.418000 0.000000 1 2 S01-06
280 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-06
281 khe Hepatocellular uptake rate 0.014291 mL/sec/cm3 0.000861 1 2 S01-06
282 Th Hepatocellular mean transit time 242.572870 sec 15.375428 1 2 S01-06
283 Kbh Biliary tissue excretion rate 0.004122 mL/sec/cm3 0.000000 1 2 S01-06
284 Khe Hepatocellular tissue uptake rate 0.062136 mL/sec/cm3 0.000000 1 2 S01-06
285 kbh Biliary excretion rate 0.003174 mL/sec/cm3 0.000000 1 2 S01-06
286 E Liver extraction fraction 0.393587 0.000000 1 2 S01-06
287 Ktrans Hepatic plasma clearance 0.008666 mL/sec/cm3 0.000000 1 2 S01-06
288 H Hematocrit 0.418000 0.000000 1 3 S01-06
289 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-06
290 khe Hepatocellular uptake rate 0.006593 mL/sec/cm3 0.000439 1 3 S01-06
291 Th Hepatocellular mean transit time 325.322720 sec 24.436474 1 3 S01-06
292 Kbh Biliary tissue excretion rate 0.003074 mL/sec/cm3 0.000000 1 3 S01-06
293 Khe Hepatocellular tissue uptake rate 0.028664 mL/sec/cm3 0.000000 1 3 S01-06
294 kbh Biliary excretion rate 0.002367 mL/sec/cm3 0.000000 1 3 S01-06
295 E Liver extraction fraction 0.230418 0.000000 1 3 S01-06
296 Ktrans Hepatic plasma clearance 0.005074 mL/sec/cm3 0.000000 1 3 S01-06
297 H Hematocrit 0.418000 0.000000 1 4 S01-06
298 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-06
299 khe Hepatocellular uptake rate 0.016688 mL/sec/cm3 0.000662 1 4 S01-06
300 Th Hepatocellular mean transit time 191.785580 sec 7.847247 1 4 S01-06
301 Kbh Biliary tissue excretion rate 0.005214 mL/sec/cm3 0.000000 1 4 S01-06
302 Khe Hepatocellular tissue uptake rate 0.072555 mL/sec/cm3 0.000000 1 4 S01-06
303 kbh Biliary excretion rate 0.004015 mL/sec/cm3 0.000000 1 4 S01-06
304 E Liver extraction fraction 0.431131 0.000000 1 4 S01-06
305 Ktrans Hepatic plasma clearance 0.009493 mL/sec/cm3 0.000000 1 4 S01-06
306 H Hematocrit 0.418000 0.000000 1 1 S01-07
307 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-07
308 khe Hepatocellular uptake rate 0.011046 mL/sec/cm3 0.000534 1 1 S01-07
309 Th Hepatocellular mean transit time 294.844598 sec 15.502774 1 1 S01-07
310 Kbh Biliary tissue excretion rate 0.003392 mL/sec/cm3 0.000000 1 1 S01-07
311 Khe Hepatocellular tissue uptake rate 0.048025 mL/sec/cm3 0.000000 1 1 S01-07
312 kbh Biliary excretion rate 0.002612 mL/sec/cm3 0.000000 1 1 S01-07
313 E Liver extraction fraction 0.334062 0.000000 1 1 S01-07
314 Ktrans Hepatic plasma clearance 0.007356 mL/sec/cm3 0.000000 1 1 S01-07
315 H Hematocrit 0.418000 0.000000 1 2 S01-07
316 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-07
317 khe Hepatocellular uptake rate 0.006140 mL/sec/cm3 0.000433 1 2 S01-07
318 Th Hepatocellular mean transit time 534.934817 sec 48.699611 1 2 S01-07
319 Kbh Biliary tissue excretion rate 0.001869 mL/sec/cm3 0.000000 1 2 S01-07
320 Khe Hepatocellular tissue uptake rate 0.026697 mL/sec/cm3 0.000000 1 2 S01-07
321 kbh Biliary excretion rate 0.001439 mL/sec/cm3 0.000000 1 2 S01-07
322 E Liver extraction fraction 0.218058 0.000000 1 2 S01-07
323 Ktrans Hepatic plasma clearance 0.004801 mL/sec/cm3 0.000000 1 2 S01-07
324 H Hematocrit 0.418000 0.000000 1 3 S01-07
325 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-07
326 khe Hepatocellular uptake rate 0.007300 mL/sec/cm3 0.000256 1 3 S01-07
327 Th Hepatocellular mean transit time 346.765820 sec 13.814794 1 3 S01-07
328 Kbh Biliary tissue excretion rate 0.002884 mL/sec/cm3 0.000000 1 3 S01-07
329 Khe Hepatocellular tissue uptake rate 0.031737 mL/sec/cm3 0.000000 1 3 S01-07
330 kbh Biliary excretion rate 0.002221 mL/sec/cm3 0.000000 1 3 S01-07
331 E Liver extraction fraction 0.248974 0.000000 1 3 S01-07
332 Ktrans Hepatic plasma clearance 0.005482 mL/sec/cm3 0.000000 1 3 S01-07
333 H Hematocrit 0.418000 0.000000 1 4 S01-07
334 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-07
335 khe Hepatocellular uptake rate 0.011719 mL/sec/cm3 0.000494 1 4 S01-07
336 Th Hepatocellular mean transit time 413.526302 sec 20.117422 1 4 S01-07
337 Kbh Biliary tissue excretion rate 0.002418 mL/sec/cm3 0.000000 1 4 S01-07
338 Khe Hepatocellular tissue uptake rate 0.050951 mL/sec/cm3 0.000000 1 4 S01-07
339 kbh Biliary excretion rate 0.001862 mL/sec/cm3 0.000000 1 4 S01-07
340 E Liver extraction fraction 0.347347 0.000000 1 4 S01-07
341 Ktrans Hepatic plasma clearance 0.007648 mL/sec/cm3 0.000000 1 4 S01-07
342 H Hematocrit 0.418000 0.000000 1 1 S01-08
343 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-08
344 khe Hepatocellular uptake rate 0.011670 mL/sec/cm3 0.000705 1 1 S01-08
345 Th Hepatocellular mean transit time 348.268073 sec 23.368511 1 1 S01-08
346 Kbh Biliary tissue excretion rate 0.002871 mL/sec/cm3 0.000000 1 1 S01-08
347 Khe Hepatocellular tissue uptake rate 0.050740 mL/sec/cm3 0.000000 1 1 S01-08
348 kbh Biliary excretion rate 0.002211 mL/sec/cm3 0.000000 1 1 S01-08
349 E Liver extraction fraction 0.346409 0.000000 1 1 S01-08
350 Ktrans Hepatic plasma clearance 0.007628 mL/sec/cm3 0.000000 1 1 S01-08
351 H Hematocrit 0.418000 0.000000 1 2 S01-08
352 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-08
353 khe Hepatocellular uptake rate 0.002659 mL/sec/cm3 0.000293 1 2 S01-08
354 Th Hepatocellular mean transit time 967.558918 sec 191.541817 1 2 S01-08
355 Kbh Biliary tissue excretion rate 0.001034 mL/sec/cm3 0.000000 1 2 S01-08
356 Khe Hepatocellular tissue uptake rate 0.011563 mL/sec/cm3 0.000000 1 2 S01-08
357 kbh Biliary excretion rate 0.000796 mL/sec/cm3 0.000000 1 2 S01-08
358 E Liver extraction fraction 0.107762 0.000000 1 2 S01-08
359 Ktrans Hepatic plasma clearance 0.002373 mL/sec/cm3 0.000000 1 2 S01-08
360 H Hematocrit 0.418000 0.000000 1 3 S01-08
361 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-08
362 khe Hepatocellular uptake rate 0.010515 mL/sec/cm3 0.000420 1 3 S01-08
363 Th Hepatocellular mean transit time 425.802086 sec 19.891952 1 3 S01-08
364 Kbh Biliary tissue excretion rate 0.002349 mL/sec/cm3 0.000000 1 3 S01-08
365 Khe Hepatocellular tissue uptake rate 0.045718 mL/sec/cm3 0.000000 1 3 S01-08
366 kbh Biliary excretion rate 0.001808 mL/sec/cm3 0.000000 1 3 S01-08
367 E Liver extraction fraction 0.323203 0.000000 1 3 S01-08
368 Ktrans Hepatic plasma clearance 0.007117 mL/sec/cm3 0.000000 1 3 S01-08
369 H Hematocrit 0.418000 0.000000 1 4 S01-08
370 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-08
371 khe Hepatocellular uptake rate 0.009289 mL/sec/cm3 0.000357 1 4 S01-08
372 Th Hepatocellular mean transit time 488.900526 sec 23.084646 1 4 S01-08
373 Kbh Biliary tissue excretion rate 0.002045 mL/sec/cm3 0.000000 1 4 S01-08
374 Khe Hepatocellular tissue uptake rate 0.040389 mL/sec/cm3 0.000000 1 4 S01-08
375 kbh Biliary excretion rate 0.001575 mL/sec/cm3 0.000000 1 4 S01-08
376 E Liver extraction fraction 0.296707 0.000000 1 4 S01-08
377 Ktrans Hepatic plasma clearance 0.006533 mL/sec/cm3 0.000000 1 4 S01-08
378 H Hematocrit 0.418000 0.000000 1 1 S01-09
379 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 1 S01-09
380 khe Hepatocellular uptake rate 0.008269 mL/sec/cm3 0.000232 1 1 S01-09
381 Th Hepatocellular mean transit time 325.545479 sec 10.218068 1 1 S01-09
382 Kbh Biliary tissue excretion rate 0.003072 mL/sec/cm3 0.000000 1 1 S01-09
383 Khe Hepatocellular tissue uptake rate 0.035951 mL/sec/cm3 0.000000 1 1 S01-09
384 kbh Biliary excretion rate 0.002365 mL/sec/cm3 0.000000 1 1 S01-09
385 E Liver extraction fraction 0.273005 0.000000 1 1 S01-09
386 Ktrans Hepatic plasma clearance 0.006011 mL/sec/cm3 0.000000 1 1 S01-09
387 H Hematocrit 0.418000 0.000000 1 2 S01-09
388 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 2 S01-09
389 khe Hepatocellular uptake rate 0.008248 mL/sec/cm3 0.000258 1 2 S01-09
390 Th Hepatocellular mean transit time 340.651061 sec 11.989710 1 2 S01-09
391 Kbh Biliary tissue excretion rate 0.002936 mL/sec/cm3 0.000000 1 2 S01-09
392 Khe Hepatocellular tissue uptake rate 0.035860 mL/sec/cm3 0.000000 1 2 S01-09
393 kbh Biliary excretion rate 0.002260 mL/sec/cm3 0.000000 1 2 S01-09
394 E Liver extraction fraction 0.272503 0.000000 1 2 S01-09
395 Ktrans Hepatic plasma clearance 0.006000 mL/sec/cm3 0.000000 1 2 S01-09
396 H Hematocrit 0.418000 0.000000 1 3 S01-09
397 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 3 S01-09
398 khe Hepatocellular uptake rate 0.011018 mL/sec/cm3 0.000610 1 3 S01-09
399 Th Hepatocellular mean transit time 349.011046 sec 21.531700 1 3 S01-09
400 Kbh Biliary tissue excretion rate 0.002865 mL/sec/cm3 0.000000 1 3 S01-09
401 Khe Hepatocellular tissue uptake rate 0.047905 mL/sec/cm3 0.000000 1 3 S01-09
402 kbh Biliary excretion rate 0.002206 mL/sec/cm3 0.000000 1 3 S01-09
403 E Liver extraction fraction 0.333509 0.000000 1 3 S01-09
404 Ktrans Hepatic plasma clearance 0.007344 mL/sec/cm3 0.000000 1 3 S01-09
405 H Hematocrit 0.418000 0.000000 1 4 S01-09
406 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 1 4 S01-09
407 khe Hepatocellular uptake rate 0.011872 mL/sec/cm3 0.000497 1 4 S01-09
408 Th Hepatocellular mean transit time 397.282304 sec 18.991896 1 4 S01-09
409 Kbh Biliary tissue excretion rate 0.002517 mL/sec/cm3 0.000000 1 4 S01-09
410 Khe Hepatocellular tissue uptake rate 0.051619 mL/sec/cm3 0.000000 1 4 S01-09
411 kbh Biliary excretion rate 0.001938 mL/sec/cm3 0.000000 1 4 S01-09
412 E Liver extraction fraction 0.350307 0.000000 1 4 S01-09
413 Ktrans Hepatic plasma clearance 0.007713 mL/sec/cm3 0.000000 1 4 S01-09
414 H Hematocrit 0.418000 0.000000 2 1 S02-10
415 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-10
416 khe Hepatocellular uptake rate 0.033112 mL/sec/cm3 0.003861 2 1 S02-10
417 Th Hepatocellular mean transit time 235.620024 sec 28.921416 2 1 S02-10
418 Kbh Biliary tissue excretion rate 0.004244 mL/sec/cm3 0.000000 2 1 S02-10
419 Khe Hepatocellular tissue uptake rate 0.143965 mL/sec/cm3 0.000000 2 1 S02-10
420 kbh Biliary excretion rate 0.003268 mL/sec/cm3 0.000000 2 1 S02-10
421 E Liver extraction fraction 0.600605 0.000000 2 1 S02-10
422 Ktrans Hepatic plasma clearance 0.013225 mL/sec/cm3 0.000000 2 1 S02-10
423 H Hematocrit 0.418000 0.000000 2 2 S02-10
424 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-10
425 khe Hepatocellular uptake rate 0.046997 mL/sec/cm3 0.006581 2 2 S02-10
426 Th Hepatocellular mean transit time 189.261962 sec 26.924762 2 2 S02-10
427 Kbh Biliary tissue excretion rate 0.005284 mL/sec/cm3 0.000000 2 2 S02-10
428 Khe Hepatocellular tissue uptake rate 0.204333 mL/sec/cm3 0.000000 2 2 S02-10
429 kbh Biliary excretion rate 0.004068 mL/sec/cm3 0.000000 2 2 S02-10
430 E Liver extraction fraction 0.680956 0.000000 2 2 S02-10
431 Ktrans Hepatic plasma clearance 0.014994 mL/sec/cm3 0.000000 2 2 S02-10
432 H Hematocrit 0.418000 0.000000 2 3 S02-10
433 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-10
434 khe Hepatocellular uptake rate 0.039437 mL/sec/cm3 0.005774 2 3 S02-10
435 Th Hepatocellular mean transit time 201.532747 sec 30.441740 2 3 S02-10
436 Kbh Biliary tissue excretion rate 0.004962 mL/sec/cm3 0.000000 2 3 S02-10
437 Khe Hepatocellular tissue uptake rate 0.171465 mL/sec/cm3 0.000000 2 3 S02-10
438 kbh Biliary excretion rate 0.003821 mL/sec/cm3 0.000000 2 3 S02-10
439 E Liver extraction fraction 0.641710 0.000000 2 3 S02-10
440 Ktrans Hepatic plasma clearance 0.014130 mL/sec/cm3 0.000000 2 3 S02-10
441 H Hematocrit 0.418000 0.000000 2 1 S02-11
442 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-11
443 khe Hepatocellular uptake rate 0.021184 mL/sec/cm3 0.001626 2 1 S02-11
444 Th Hepatocellular mean transit time 296.420460 sec 25.207575 2 1 S02-11
445 Kbh Biliary tissue excretion rate 0.003374 mL/sec/cm3 0.000000 2 1 S02-11
446 Khe Hepatocellular tissue uptake rate 0.092103 mL/sec/cm3 0.000000 2 1 S02-11
447 kbh Biliary excretion rate 0.002598 mL/sec/cm3 0.000000 2 1 S02-11
448 E Liver extraction fraction 0.490332 0.000000 2 1 S02-11
449 Ktrans Hepatic plasma clearance 0.010797 mL/sec/cm3 0.000000 2 1 S02-11
450 H Hematocrit 0.418000 0.000000 2 2 S02-11
451 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-11
452 khe Hepatocellular uptake rate 0.001947 mL/sec/cm3 0.000388 2 2 S02-11
453 Th Hepatocellular mean transit time 994.000498 sec 383.078666 2 2 S02-11
454 Kbh Biliary tissue excretion rate 0.001006 mL/sec/cm3 0.000000 2 2 S02-11
455 Khe Hepatocellular tissue uptake rate 0.008463 mL/sec/cm3 0.000000 2 2 S02-11
456 kbh Biliary excretion rate 0.000775 mL/sec/cm3 0.000000 2 2 S02-11
457 E Liver extraction fraction 0.081223 0.000000 2 2 S02-11
458 Ktrans Hepatic plasma clearance 0.001788 mL/sec/cm3 0.000000 2 2 S02-11
459 H Hematocrit 0.418000 0.000000 2 3 S02-11
460 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-11
461 khe Hepatocellular uptake rate 0.003697 mL/sec/cm3 0.000553 2 3 S02-11
462 Th Hepatocellular mean transit time 738.371001 sec 176.773271 2 3 S02-11
463 Kbh Biliary tissue excretion rate 0.001354 mL/sec/cm3 0.000000 2 3 S02-11
464 Khe Hepatocellular tissue uptake rate 0.016075 mL/sec/cm3 0.000000 2 3 S02-11
465 kbh Biliary excretion rate 0.001043 mL/sec/cm3 0.000000 2 3 S02-11
466 E Liver extraction fraction 0.143768 0.000000 2 3 S02-11
467 Ktrans Hepatic plasma clearance 0.003166 mL/sec/cm3 0.000000 2 3 S02-11
468 H Hematocrit 0.418000 0.000000 2 1 S02-12
469 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-12
470 khe Hepatocellular uptake rate 0.033331 mL/sec/cm3 0.002803 2 1 S02-12
471 Th Hepatocellular mean transit time 327.775686 sec 30.151847 2 1 S02-12
472 Kbh Biliary tissue excretion rate 0.003051 mL/sec/cm3 0.000000 2 1 S02-12
473 Khe Hepatocellular tissue uptake rate 0.144918 mL/sec/cm3 0.000000 2 1 S02-12
474 kbh Biliary excretion rate 0.002349 mL/sec/cm3 0.000000 2 1 S02-12
475 E Liver extraction fraction 0.602187 0.000000 2 1 S02-12
476 Ktrans Hepatic plasma clearance 0.013260 mL/sec/cm3 0.000000 2 1 S02-12
477 H Hematocrit 0.418000 0.000000 2 2 S02-12
478 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-12
479 khe Hepatocellular uptake rate 0.004196 mL/sec/cm3 0.000621 2 2 S02-12
480 Th Hepatocellular mean transit time 767.727313 sec 185.616425 2 2 S02-12
481 Kbh Biliary tissue excretion rate 0.001303 mL/sec/cm3 0.000000 2 2 S02-12
482 Khe Hepatocellular tissue uptake rate 0.018242 mL/sec/cm3 0.000000 2 2 S02-12
483 kbh Biliary excretion rate 0.001003 mL/sec/cm3 0.000000 2 2 S02-12
484 E Liver extraction fraction 0.160051 0.000000 2 2 S02-12
485 Ktrans Hepatic plasma clearance 0.003524 mL/sec/cm3 0.000000 2 2 S02-12
486 H Hematocrit 0.418000 0.000000 2 3 S02-12
487 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-12
488 khe Hepatocellular uptake rate 0.003780 mL/sec/cm3 0.000617 2 3 S02-12
489 Th Hepatocellular mean transit time 875.317163 sec 253.321504 2 3 S02-12
490 Kbh Biliary tissue excretion rate 0.001142 mL/sec/cm3 0.000000 2 3 S02-12
491 Khe Hepatocellular tissue uptake rate 0.016436 mL/sec/cm3 0.000000 2 3 S02-12
492 kbh Biliary excretion rate 0.000880 mL/sec/cm3 0.000000 2 3 S02-12
493 E Liver extraction fraction 0.146529 0.000000 2 3 S02-12
494 Ktrans Hepatic plasma clearance 0.003226 mL/sec/cm3 0.000000 2 3 S02-12
495 H Hematocrit 0.418000 0.000000 2 1 S02-13
496 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-13
497 khe Hepatocellular uptake rate 0.039150 mL/sec/cm3 0.004911 2 1 S02-13
498 Th Hepatocellular mean transit time 204.471388 sec 26.489246 2 1 S02-13
499 Kbh Biliary tissue excretion rate 0.004891 mL/sec/cm3 0.000000 2 1 S02-13
500 Khe Hepatocellular tissue uptake rate 0.170218 mL/sec/cm3 0.000000 2 1 S02-13
501 kbh Biliary excretion rate 0.003766 mL/sec/cm3 0.000000 2 1 S02-13
502 E Liver extraction fraction 0.640031 0.000000 2 1 S02-13
503 Ktrans Hepatic plasma clearance 0.014093 mL/sec/cm3 0.000000 2 1 S02-13
504 H Hematocrit 0.418000 0.000000 2 2 S02-13
505 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-13
506 khe Hepatocellular uptake rate 0.003361 mL/sec/cm3 0.000460 2 2 S02-13
507 Th Hepatocellular mean transit time 682.319533 sec 143.183808 2 2 S02-13
508 Kbh Biliary tissue excretion rate 0.001466 mL/sec/cm3 0.000000 2 2 S02-13
509 Khe Hepatocellular tissue uptake rate 0.014611 mL/sec/cm3 0.000000 2 2 S02-13
510 kbh Biliary excretion rate 0.001129 mL/sec/cm3 0.000000 2 2 S02-13
511 E Liver extraction fraction 0.132411 0.000000 2 2 S02-13
512 Ktrans Hepatic plasma clearance 0.002916 mL/sec/cm3 0.000000 2 2 S02-13
513 H Hematocrit 0.418000 0.000000 2 1 S02-01
514 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-01
515 khe Hepatocellular uptake rate 0.021234 mL/sec/cm3 0.001323 2 1 S02-01
516 Th Hepatocellular mean transit time 445.709125 sec 33.837966 2 1 S02-01
517 Kbh Biliary tissue excretion rate 0.002244 mL/sec/cm3 0.000000 2 1 S02-01
518 Khe Hepatocellular tissue uptake rate 0.092321 mL/sec/cm3 0.000000 2 1 S02-01
519 kbh Biliary excretion rate 0.001728 mL/sec/cm3 0.000000 2 1 S02-01
520 E Liver extraction fraction 0.490924 0.000000 2 1 S02-01
521 Ktrans Hepatic plasma clearance 0.010810 mL/sec/cm3 0.000000 2 1 S02-01
522 H Hematocrit 0.418000 0.000000 2 2 S02-01
523 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-01
524 khe Hepatocellular uptake rate 0.001764 mL/sec/cm3 0.000209 2 2 S02-01
525 Th Hepatocellular mean transit time 946.697311 sec 210.231871 2 2 S02-01
526 Kbh Biliary tissue excretion rate 0.001056 mL/sec/cm3 0.000000 2 2 S02-01
527 Khe Hepatocellular tissue uptake rate 0.007668 mL/sec/cm3 0.000000 2 2 S02-01
528 kbh Biliary excretion rate 0.000813 mL/sec/cm3 0.000000 2 2 S02-01
529 E Liver extraction fraction 0.074158 0.000000 2 2 S02-01
530 Ktrans Hepatic plasma clearance 0.001633 mL/sec/cm3 0.000000 2 2 S02-01
531 H Hematocrit 0.418000 0.000000 2 1 S02-02
532 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-02
533 khe Hepatocellular uptake rate 0.025439 mL/sec/cm3 0.001669 2 1 S02-02
534 Th Hepatocellular mean transit time 400.946896 sec 30.716632 2 1 S02-02
535 Kbh Biliary tissue excretion rate 0.002494 mL/sec/cm3 0.000000 2 1 S02-02
536 Khe Hepatocellular tissue uptake rate 0.110604 mL/sec/cm3 0.000000 2 1 S02-02
537 kbh Biliary excretion rate 0.001920 mL/sec/cm3 0.000000 2 1 S02-02
538 E Liver extraction fraction 0.536030 0.000000 2 1 S02-02
539 Ktrans Hepatic plasma clearance 0.011803 mL/sec/cm3 0.000000 2 1 S02-02
540 H Hematocrit 0.418000 0.000000 2 2 S02-02
541 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-02
542 khe Hepatocellular uptake rate 0.003262 mL/sec/cm3 0.000459 2 2 S02-02
543 Th Hepatocellular mean transit time 811.695441 sec 193.168158 2 2 S02-02
544 Kbh Biliary tissue excretion rate 0.001232 mL/sec/cm3 0.000000 2 2 S02-02
545 Khe Hepatocellular tissue uptake rate 0.014184 mL/sec/cm3 0.000000 2 2 S02-02
546 kbh Biliary excretion rate 0.000949 mL/sec/cm3 0.000000 2 2 S02-02
547 E Liver extraction fraction 0.129039 0.000000 2 2 S02-02
548 Ktrans Hepatic plasma clearance 0.002841 mL/sec/cm3 0.000000 2 2 S02-02
549 H Hematocrit 0.418000 0.000000 2 3 S02-02
550 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-02
551 khe Hepatocellular uptake rate 0.002429 mL/sec/cm3 0.000334 2 3 S02-02
552 Th Hepatocellular mean transit time 1235.243836 sec 382.791656 2 3 S02-02
553 Kbh Biliary tissue excretion rate 0.000810 mL/sec/cm3 0.000000 2 3 S02-02
554 Khe Hepatocellular tissue uptake rate 0.010561 mL/sec/cm3 0.000000 2 3 S02-02
555 kbh Biliary excretion rate 0.000623 mL/sec/cm3 0.000000 2 3 S02-02
556 E Liver extraction fraction 0.099357 0.000000 2 3 S02-02
557 Ktrans Hepatic plasma clearance 0.002188 mL/sec/cm3 0.000000 2 3 S02-02
558 H Hematocrit 0.418000 0.000000 2 1 S02-03
559 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-03
560 khe Hepatocellular uptake rate 0.029708 mL/sec/cm3 0.001956 2 1 S02-03
561 Th Hepatocellular mean transit time 319.881225 sec 23.125250 2 1 S02-03
562 Kbh Biliary tissue excretion rate 0.003126 mL/sec/cm3 0.000000 2 1 S02-03
563 Khe Hepatocellular tissue uptake rate 0.129164 mL/sec/cm3 0.000000 2 1 S02-03
564 kbh Biliary excretion rate 0.002407 mL/sec/cm3 0.000000 2 1 S02-03
565 E Liver extraction fraction 0.574320 0.000000 2 1 S02-03
566 Ktrans Hepatic plasma clearance 0.012646 mL/sec/cm3 0.000000 2 1 S02-03
567 H Hematocrit 0.418000 0.000000 2 2 S02-03
568 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-03
569 khe Hepatocellular uptake rate 0.038069 mL/sec/cm3 0.004001 2 2 S02-03
570 Th Hepatocellular mean transit time 241.038074 sec 26.431877 2 2 S02-03
571 Kbh Biliary tissue excretion rate 0.004149 mL/sec/cm3 0.000000 2 2 S02-03
572 Khe Hepatocellular tissue uptake rate 0.165518 mL/sec/cm3 0.000000 2 2 S02-03
573 kbh Biliary excretion rate 0.003195 mL/sec/cm3 0.000000 2 2 S02-03
574 E Liver extraction fraction 0.633555 0.000000 2 2 S02-03
575 Ktrans Hepatic plasma clearance 0.013950 mL/sec/cm3 0.000000 2 2 S02-03
576 H Hematocrit 0.418000 0.000000 2 3 S02-03
577 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-03
578 khe Hepatocellular uptake rate 0.039354 mL/sec/cm3 0.003759 2 3 S02-03
579 Th Hepatocellular mean transit time 291.082102 sec 29.463169 2 3 S02-03
580 Kbh Biliary tissue excretion rate 0.003435 mL/sec/cm3 0.000000 2 3 S02-03
581 Khe Hepatocellular tissue uptake rate 0.171103 mL/sec/cm3 0.000000 2 3 S02-03
582 kbh Biliary excretion rate 0.002645 mL/sec/cm3 0.000000 2 3 S02-03
583 E Liver extraction fraction 0.641225 0.000000 2 3 S02-03
584 Ktrans Hepatic plasma clearance 0.014119 mL/sec/cm3 0.000000 2 3 S02-03
585 H Hematocrit 0.418000 0.000000 2 1 S02-04
586 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-04
587 khe Hepatocellular uptake rate 0.034651 mL/sec/cm3 0.003536 2 1 S02-04
588 Th Hepatocellular mean transit time 271.868035 sec 29.462149 2 1 S02-04
589 Kbh Biliary tissue excretion rate 0.003678 mL/sec/cm3 0.000000 2 1 S02-04
590 Khe Hepatocellular tissue uptake rate 0.150656 mL/sec/cm3 0.000000 2 1 S02-04
591 kbh Biliary excretion rate 0.002832 mL/sec/cm3 0.000000 2 1 S02-04
592 E Liver extraction fraction 0.611451 0.000000 2 1 S02-04
593 Ktrans Hepatic plasma clearance 0.013464 mL/sec/cm3 0.000000 2 1 S02-04
594 H Hematocrit 0.418000 0.000000 2 2 S02-04
595 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-04
596 khe Hepatocellular uptake rate 0.041785 mL/sec/cm3 0.003907 2 2 S02-04
597 Th Hepatocellular mean transit time 277.735620 sec 27.220410 2 2 S02-04
598 Kbh Biliary tissue excretion rate 0.003601 mL/sec/cm3 0.000000 2 2 S02-04
599 Khe Hepatocellular tissue uptake rate 0.181673 mL/sec/cm3 0.000000 2 2 S02-04
600 kbh Biliary excretion rate 0.002772 mL/sec/cm3 0.000000 2 2 S02-04
601 E Liver extraction fraction 0.654895 0.000000 2 2 S02-04
602 Ktrans Hepatic plasma clearance 0.014420 mL/sec/cm3 0.000000 2 2 S02-04
603 H Hematocrit 0.418000 0.000000 2 3 S02-04
604 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-04
605 khe Hepatocellular uptake rate 0.045374 mL/sec/cm3 0.004490 2 3 S02-04
606 Th Hepatocellular mean transit time 303.252561 sec 31.581094 2 3 S02-04
607 Kbh Biliary tissue excretion rate 0.003298 mL/sec/cm3 0.000000 2 3 S02-04
608 Khe Hepatocellular tissue uptake rate 0.197278 mL/sec/cm3 0.000000 2 3 S02-04
609 kbh Biliary excretion rate 0.002539 mL/sec/cm3 0.000000 2 3 S02-04
610 E Liver extraction fraction 0.673274 0.000000 2 3 S02-04
611 Ktrans Hepatic plasma clearance 0.014825 mL/sec/cm3 0.000000 2 3 S02-04
612 H Hematocrit 0.418000 0.000000 2 1 S02-05
613 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-05
614 khe Hepatocellular uptake rate 0.029670 mL/sec/cm3 0.002393 2 1 S02-05
615 Th Hepatocellular mean transit time 339.699622 sec 30.432673 2 1 S02-05
616 Kbh Biliary tissue excretion rate 0.002944 mL/sec/cm3 0.000000 2 1 S02-05
617 Khe Hepatocellular tissue uptake rate 0.128999 mL/sec/cm3 0.000000 2 1 S02-05
618 kbh Biliary excretion rate 0.002267 mL/sec/cm3 0.000000 2 1 S02-05
619 E Liver extraction fraction 0.574009 0.000000 2 1 S02-05
620 Ktrans Hepatic plasma clearance 0.012639 mL/sec/cm3 0.000000 2 1 S02-05
621 H Hematocrit 0.418000 0.000000 2 2 S02-05
622 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-05
623 khe Hepatocellular uptake rate 0.026065 mL/sec/cm3 0.002304 2 2 S02-05
624 Th Hepatocellular mean transit time 343.631652 sec 34.102096 2 2 S02-05
625 Kbh Biliary tissue excretion rate 0.002910 mL/sec/cm3 0.000000 2 2 S02-05
626 Khe Hepatocellular tissue uptake rate 0.113325 mL/sec/cm3 0.000000 2 2 S02-05
627 kbh Biliary excretion rate 0.002241 mL/sec/cm3 0.000000 2 2 S02-05
628 E Liver extraction fraction 0.542069 0.000000 2 2 S02-05
629 Ktrans Hepatic plasma clearance 0.011936 mL/sec/cm3 0.000000 2 2 S02-05
630 H Hematocrit 0.418000 0.000000 2 3 S02-05
631 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-05
632 khe Hepatocellular uptake rate 0.028257 mL/sec/cm3 0.001605 2 3 S02-05
633 Th Hepatocellular mean transit time 390.260253 sec 24.879173 2 3 S02-05
634 Kbh Biliary tissue excretion rate 0.002562 mL/sec/cm3 0.000000 2 3 S02-05
635 Khe Hepatocellular tissue uptake rate 0.122858 mL/sec/cm3 0.000000 2 3 S02-05
636 kbh Biliary excretion rate 0.001973 mL/sec/cm3 0.000000 2 3 S02-05
637 E Liver extraction fraction 0.562040 0.000000 2 3 S02-05
638 Ktrans Hepatic plasma clearance 0.012376 mL/sec/cm3 0.000000 2 3 S02-05
639 H Hematocrit 0.418000 0.000000 2 1 S02-06
640 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-06
641 khe Hepatocellular uptake rate 0.032433 mL/sec/cm3 0.003232 2 1 S02-06
642 Th Hepatocellular mean transit time 307.557296 sec 33.235168 2 1 S02-06
643 Kbh Biliary tissue excretion rate 0.003251 mL/sec/cm3 0.000000 2 1 S02-06
644 Khe Hepatocellular tissue uptake rate 0.141014 mL/sec/cm3 0.000000 2 1 S02-06
645 kbh Biliary excretion rate 0.002504 mL/sec/cm3 0.000000 2 1 S02-06
646 E Liver extraction fraction 0.595627 0.000000 2 1 S02-06
647 Ktrans Hepatic plasma clearance 0.013115 mL/sec/cm3 0.000000 2 1 S02-06
648 H Hematocrit 0.418000 0.000000 2 2 S02-06
649 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-06
650 khe Hepatocellular uptake rate 0.037131 mL/sec/cm3 0.003858 2 2 S02-06
651 Th Hepatocellular mean transit time 255.163021 sec 27.837065 2 2 S02-06
652 Kbh Biliary tissue excretion rate 0.003919 mL/sec/cm3 0.000000 2 2 S02-06
653 Khe Hepatocellular tissue uptake rate 0.161437 mL/sec/cm3 0.000000 2 2 S02-06
654 kbh Biliary excretion rate 0.003018 mL/sec/cm3 0.000000 2 2 S02-06
655 E Liver extraction fraction 0.627741 0.000000 2 2 S02-06
656 Ktrans Hepatic plasma clearance 0.013822 mL/sec/cm3 0.000000 2 2 S02-06
657 H Hematocrit 0.418000 0.000000 2 3 S02-06
658 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-06
659 khe Hepatocellular uptake rate 0.041152 mL/sec/cm3 0.003960 2 3 S02-06
660 Th Hepatocellular mean transit time 292.157416 sec 29.693316 2 3 S02-06
661 Kbh Biliary tissue excretion rate 0.003423 mL/sec/cm3 0.000000 2 3 S02-06
662 Khe Hepatocellular tissue uptake rate 0.178921 mL/sec/cm3 0.000000 2 3 S02-06
663 kbh Biliary excretion rate 0.002636 mL/sec/cm3 0.000000 2 3 S02-06
664 E Liver extraction fraction 0.651437 0.000000 2 3 S02-06
665 Ktrans Hepatic plasma clearance 0.014344 mL/sec/cm3 0.000000 2 3 S02-06
666 H Hematocrit 0.418000 0.000000 2 1 S02-07
667 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-07
668 khe Hepatocellular uptake rate 0.024099 mL/sec/cm3 0.001930 2 1 S02-07
669 Th Hepatocellular mean transit time 384.292751 sec 35.641988 2 1 S02-07
670 Kbh Biliary tissue excretion rate 0.002602 mL/sec/cm3 0.000000 2 1 S02-07
671 Khe Hepatocellular tissue uptake rate 0.104778 mL/sec/cm3 0.000000 2 1 S02-07
672 kbh Biliary excretion rate 0.002004 mL/sec/cm3 0.000000 2 1 S02-07
673 E Liver extraction fraction 0.522549 0.000000 2 1 S02-07
674 Ktrans Hepatic plasma clearance 0.011506 mL/sec/cm3 0.000000 2 1 S02-07
675 H Hematocrit 0.418000 0.000000 2 2 S02-07
676 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-07
677 khe Hepatocellular uptake rate 0.002941 mL/sec/cm3 0.000483 2 2 S02-07
678 Th Hepatocellular mean transit time 811.928946 sec 225.756469 2 2 S02-07
679 Kbh Biliary tissue excretion rate 0.001232 mL/sec/cm3 0.000000 2 2 S02-07
680 Khe Hepatocellular tissue uptake rate 0.012786 mL/sec/cm3 0.000000 2 2 S02-07
681 kbh Biliary excretion rate 0.000948 mL/sec/cm3 0.000000 2 2 S02-07
682 E Liver extraction fraction 0.117824 0.000000 2 2 S02-07
683 Ktrans Hepatic plasma clearance 0.002594 mL/sec/cm3 0.000000 2 2 S02-07
684 H Hematocrit 0.418000 0.000000 2 3 S02-07
685 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-07
686 khe Hepatocellular uptake rate 0.003205 mL/sec/cm3 0.000451 2 3 S02-07
687 Th Hepatocellular mean transit time 949.340030 sec 249.605449 2 3 S02-07
688 Kbh Biliary tissue excretion rate 0.001053 mL/sec/cm3 0.000000 2 3 S02-07
689 Khe Hepatocellular tissue uptake rate 0.013937 mL/sec/cm3 0.000000 2 3 S02-07
690 kbh Biliary excretion rate 0.000811 mL/sec/cm3 0.000000 2 3 S02-07
691 E Liver extraction fraction 0.127078 0.000000 2 3 S02-07
692 Ktrans Hepatic plasma clearance 0.002798 mL/sec/cm3 0.000000 2 3 S02-07
693 H Hematocrit 0.418000 0.000000 2 1 S02-08
694 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-08
695 khe Hepatocellular uptake rate 0.027113 mL/sec/cm3 0.002562 2 1 S02-08
696 Th Hepatocellular mean transit time 357.212389 sec 38.121451 2 1 S02-08
697 Kbh Biliary tissue excretion rate 0.002799 mL/sec/cm3 0.000000 2 1 S02-08
698 Khe Hepatocellular tissue uptake rate 0.117884 mL/sec/cm3 0.000000 2 1 S02-08
699 kbh Biliary excretion rate 0.002156 mL/sec/cm3 0.000000 2 1 S02-08
700 E Liver extraction fraction 0.551844 0.000000 2 1 S02-08
701 Ktrans Hepatic plasma clearance 0.012151 mL/sec/cm3 0.000000 2 1 S02-08
702 H Hematocrit 0.418000 0.000000 2 2 S02-08
703 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-08
704 khe Hepatocellular uptake rate 0.003043 mL/sec/cm3 0.000517 2 2 S02-08
705 Th Hepatocellular mean transit time 671.614983 sec 173.618331 2 2 S02-08
706 Kbh Biliary tissue excretion rate 0.001489 mL/sec/cm3 0.000000 2 2 S02-08
707 Khe Hepatocellular tissue uptake rate 0.013229 mL/sec/cm3 0.000000 2 2 S02-08
708 kbh Biliary excretion rate 0.001146 mL/sec/cm3 0.000000 2 2 S02-08
709 E Liver extraction fraction 0.121409 0.000000 2 2 S02-08
710 Ktrans Hepatic plasma clearance 0.002673 mL/sec/cm3 0.000000 2 2 S02-08
711 H Hematocrit 0.418000 0.000000 2 3 S02-08
712 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-08
713 khe Hepatocellular uptake rate 0.005026 mL/sec/cm3 0.000595 2 3 S02-08
714 Th Hepatocellular mean transit time 833.169027 sec 168.968813 2 3 S02-08
715 Kbh Biliary tissue excretion rate 0.001200 mL/sec/cm3 0.000000 2 3 S02-08
716 Khe Hepatocellular tissue uptake rate 0.021854 mL/sec/cm3 0.000000 2 3 S02-08
717 kbh Biliary excretion rate 0.000924 mL/sec/cm3 0.000000 2 3 S02-08
718 E Liver extraction fraction 0.185852 0.000000 2 3 S02-08
719 Ktrans Hepatic plasma clearance 0.004092 mL/sec/cm3 0.000000 2 3 S02-08
720 H Hematocrit 0.418000 0.000000 2 1 S02-09
721 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 1 S02-09
722 khe Hepatocellular uptake rate 0.023804 mL/sec/cm3 0.001659 2 1 S02-09
723 Th Hepatocellular mean transit time 295.900874 sec 22.692724 2 1 S02-09
724 Kbh Biliary tissue excretion rate 0.003380 mL/sec/cm3 0.000000 2 1 S02-09
725 Khe Hepatocellular tissue uptake rate 0.103497 mL/sec/cm3 0.000000 2 1 S02-09
726 kbh Biliary excretion rate 0.002602 mL/sec/cm3 0.000000 2 1 S02-09
727 E Liver extraction fraction 0.519479 0.000000 2 1 S02-09
728 Ktrans Hepatic plasma clearance 0.011438 mL/sec/cm3 0.000000 2 1 S02-09
729 H Hematocrit 0.418000 0.000000 2 2 S02-09
730 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 2 S02-09
731 khe Hepatocellular uptake rate 0.038737 mL/sec/cm3 0.005048 2 2 S02-09
732 Th Hepatocellular mean transit time 216.494162 sec 29.223576 2 2 S02-09
733 Kbh Biliary tissue excretion rate 0.004619 mL/sec/cm3 0.000000 2 2 S02-09
734 Khe Hepatocellular tissue uptake rate 0.168423 mL/sec/cm3 0.000000 2 2 S02-09
735 kbh Biliary excretion rate 0.003557 mL/sec/cm3 0.000000 2 2 S02-09
736 E Liver extraction fraction 0.637584 0.000000 2 2 S02-09
737 Ktrans Hepatic plasma clearance 0.014039 mL/sec/cm3 0.000000 2 2 S02-09
738 H Hematocrit 0.418000 0.000000 2 3 S02-09
739 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 2 3 S02-09
740 khe Hepatocellular uptake rate 0.025780 mL/sec/cm3 0.001996 2 3 S02-09
741 Th Hepatocellular mean transit time 337.643064 sec 29.263491 2 3 S02-09
742 Kbh Biliary tissue excretion rate 0.002962 mL/sec/cm3 0.000000 2 3 S02-09
743 Khe Hepatocellular tissue uptake rate 0.112088 mL/sec/cm3 0.000000 2 3 S02-09
744 kbh Biliary excretion rate 0.002281 mL/sec/cm3 0.000000 2 3 S02-09
745 E Liver extraction fraction 0.539344 0.000000 2 3 S02-09
746 Ktrans Hepatic plasma clearance 0.011876 mL/sec/cm3 0.000000 2 3 S02-09
747 H Hematocrit 0.418000 0.000000 3 1 S03-01
748 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-01
749 khe Hepatocellular uptake rate 0.013878 mL/sec/cm3 0.000871 3 1 S03-01
750 Th Hepatocellular mean transit time 221.663872 sec 15.373636 3 1 S03-01
751 Kbh Biliary tissue excretion rate 0.004511 mL/sec/cm3 0.000000 3 1 S03-01
752 Khe Hepatocellular tissue uptake rate 0.060339 mL/sec/cm3 0.000000 3 1 S03-01
753 kbh Biliary excretion rate 0.003474 mL/sec/cm3 0.000000 3 1 S03-01
754 E Liver extraction fraction 0.386605 0.000000 3 1 S03-01
755 Ktrans Hepatic plasma clearance 0.008513 mL/sec/cm3 0.000000 3 1 S03-01
756 H Hematocrit 0.418000 0.000000 3 2 S03-01
757 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-01
758 khe Hepatocellular uptake rate 0.020542 mL/sec/cm3 0.001571 3 2 S03-01
759 Th Hepatocellular mean transit time 247.053382 sec 20.756601 3 2 S03-01
760 Kbh Biliary tissue excretion rate 0.004048 mL/sec/cm3 0.000000 3 2 S03-01
761 Khe Hepatocellular tissue uptake rate 0.089313 mL/sec/cm3 0.000000 3 2 S03-01
762 kbh Biliary excretion rate 0.003117 mL/sec/cm3 0.000000 3 2 S03-01
763 E Liver extraction fraction 0.482648 0.000000 3 2 S03-01
764 Ktrans Hepatic plasma clearance 0.010627 mL/sec/cm3 0.000000 3 2 S03-01
765 H Hematocrit 0.418000 0.000000 3 1 S03-02
766 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-02
767 khe Hepatocellular uptake rate 0.024471 mL/sec/cm3 0.001575 3 1 S03-02
768 Th Hepatocellular mean transit time 302.324666 sec 21.708634 3 1 S03-02
769 Kbh Biliary tissue excretion rate 0.003308 mL/sec/cm3 0.000000 3 1 S03-02
770 Khe Hepatocellular tissue uptake rate 0.106395 mL/sec/cm3 0.000000 3 1 S03-02
771 kbh Biliary excretion rate 0.002547 mL/sec/cm3 0.000000 3 1 S03-02
772 E Liver extraction fraction 0.526369 0.000000 3 1 S03-02
773 Ktrans Hepatic plasma clearance 0.011590 mL/sec/cm3 0.000000 3 1 S03-02
774 H Hematocrit 0.418000 0.000000 3 2 S03-02
775 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-02
776 khe Hepatocellular uptake rate 0.022383 mL/sec/cm3 0.001349 3 2 S03-02
777 Th Hepatocellular mean transit time 288.271988 sec 19.335446 3 2 S03-02
778 Kbh Biliary tissue excretion rate 0.003469 mL/sec/cm3 0.000000 3 2 S03-02
779 Khe Hepatocellular tissue uptake rate 0.097316 mL/sec/cm3 0.000000 3 2 S03-02
780 kbh Biliary excretion rate 0.002671 mL/sec/cm3 0.000000 3 2 S03-02
781 E Liver extraction fraction 0.504094 0.000000 3 2 S03-02
782 Ktrans Hepatic plasma clearance 0.011100 mL/sec/cm3 0.000000 3 2 S03-02
783 H Hematocrit 0.418000 0.000000 3 1 S03-03
784 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-03
785 khe Hepatocellular uptake rate 0.030478 mL/sec/cm3 0.002652 3 1 S03-03
786 Th Hepatocellular mean transit time 224.327038 sec 20.889863 3 1 S03-03
787 Kbh Biliary tissue excretion rate 0.004458 mL/sec/cm3 0.000000 3 1 S03-03
788 Khe Hepatocellular tissue uptake rate 0.132512 mL/sec/cm3 0.000000 3 1 S03-03
789 kbh Biliary excretion rate 0.003432 mL/sec/cm3 0.000000 3 1 S03-03
790 E Liver extraction fraction 0.580565 0.000000 3 1 S03-03
791 Ktrans Hepatic plasma clearance 0.012783 mL/sec/cm3 0.000000 3 1 S03-03
792 H Hematocrit 0.418000 0.000000 3 2 S03-03
793 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-03
794 khe Hepatocellular uptake rate 0.038609 mL/sec/cm3 0.003628 3 2 S03-03
795 Th Hepatocellular mean transit time 224.923479 sec 22.292314 3 2 S03-03
796 Kbh Biliary tissue excretion rate 0.004446 mL/sec/cm3 0.000000 3 2 S03-03
797 Khe Hepatocellular tissue uptake rate 0.167863 mL/sec/cm3 0.000000 3 2 S03-03
798 kbh Biliary excretion rate 0.003423 mL/sec/cm3 0.000000 3 2 S03-03
799 E Liver extraction fraction 0.636815 0.000000 3 2 S03-03
800 Ktrans Hepatic plasma clearance 0.014022 mL/sec/cm3 0.000000 3 2 S03-03
801 H Hematocrit 0.418000 0.000000 3 1 S03-04
802 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-04
803 khe Hepatocellular uptake rate 0.025619 mL/sec/cm3 0.002110 3 1 S03-04
804 Th Hepatocellular mean transit time 248.559512 sec 22.275827 3 1 S03-04
805 Kbh Biliary tissue excretion rate 0.004023 mL/sec/cm3 0.000000 3 1 S03-04
806 Khe Hepatocellular tissue uptake rate 0.111385 mL/sec/cm3 0.000000 3 1 S03-04
807 kbh Biliary excretion rate 0.003098 mL/sec/cm3 0.000000 3 1 S03-04
808 E Liver extraction fraction 0.537781 0.000000 3 1 S03-04
809 Ktrans Hepatic plasma clearance 0.011841 mL/sec/cm3 0.000000 3 1 S03-04
810 H Hematocrit 0.418000 0.000000 3 2 S03-04
811 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-04
812 khe Hepatocellular uptake rate 0.016949 mL/sec/cm3 0.001533 3 2 S03-04
813 Th Hepatocellular mean transit time 205.938968 sec 20.350920 3 2 S03-04
814 Kbh Biliary tissue excretion rate 0.004856 mL/sec/cm3 0.000000 3 2 S03-04
815 Khe Hepatocellular tissue uptake rate 0.073691 mL/sec/cm3 0.000000 3 2 S03-04
816 kbh Biliary excretion rate 0.003739 mL/sec/cm3 0.000000 3 2 S03-04
817 E Liver extraction fraction 0.434944 0.000000 3 2 S03-04
818 Ktrans Hepatic plasma clearance 0.009577 mL/sec/cm3 0.000000 3 2 S03-04
819 H Hematocrit 0.418000 0.000000 3 1 S03-05
820 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-05
821 khe Hepatocellular uptake rate 0.027619 mL/sec/cm3 0.002204 3 1 S03-05
822 Th Hepatocellular mean transit time 286.618569 sec 25.162528 3 1 S03-05
823 Kbh Biliary tissue excretion rate 0.003489 mL/sec/cm3 0.000000 3 1 S03-05
824 Khe Hepatocellular tissue uptake rate 0.120082 mL/sec/cm3 0.000000 3 1 S03-05
825 kbh Biliary excretion rate 0.002686 mL/sec/cm3 0.000000 3 1 S03-05
826 E Liver extraction fraction 0.556407 0.000000 3 1 S03-05
827 Ktrans Hepatic plasma clearance 0.012252 mL/sec/cm3 0.000000 3 1 S03-05
828 H Hematocrit 0.418000 0.000000 3 2 S03-05
829 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-05
830 khe Hepatocellular uptake rate 0.022092 mL/sec/cm3 0.001436 3 2 S03-05
831 Th Hepatocellular mean transit time 280.771730 sec 20.256932 3 2 S03-05
832 Kbh Biliary tissue excretion rate 0.003562 mL/sec/cm3 0.000000 3 2 S03-05
833 Khe Hepatocellular tissue uptake rate 0.096051 mL/sec/cm3 0.000000 3 2 S03-05
834 kbh Biliary excretion rate 0.002742 mL/sec/cm3 0.000000 3 2 S03-05
835 E Liver extraction fraction 0.500825 0.000000 3 2 S03-05
836 Ktrans Hepatic plasma clearance 0.011028 mL/sec/cm3 0.000000 3 2 S03-05
837 H Hematocrit 0.418000 0.000000 3 1 S03-06
838 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 1 S03-06
839 khe Hepatocellular uptake rate 0.031736 mL/sec/cm3 0.002392 3 1 S03-06
840 Th Hepatocellular mean transit time 258.546517 sec 21.028975 3 1 S03-06
841 Kbh Biliary tissue excretion rate 0.003868 mL/sec/cm3 0.000000 3 1 S03-06
842 Khe Hepatocellular tissue uptake rate 0.137984 mL/sec/cm3 0.000000 3 1 S03-06
843 kbh Biliary excretion rate 0.002978 mL/sec/cm3 0.000000 3 1 S03-06
844 E Liver extraction fraction 0.590384 0.000000 3 1 S03-06
845 Ktrans Hepatic plasma clearance 0.013000 mL/sec/cm3 0.000000 3 1 S03-06
846 H Hematocrit 0.418000 0.000000 3 2 S03-06
847 ve Liver extracellular volume fraction 0.230000 mL/cm3 0.000000 3 2 S03-06
848 khe Hepatocellular uptake rate 0.022781 mL/sec/cm3 0.001649 3 2 S03-06
849 Th Hepatocellular mean transit time 283.462777 sec 22.764106 3 2 S03-06
850 Kbh Biliary tissue excretion rate 0.003528 mL/sec/cm3 0.000000 3 2 S03-06
851 Khe Hepatocellular tissue uptake rate 0.099049 mL/sec/cm3 0.000000 3 2 S03-06
852 kbh Biliary excretion rate 0.002716 mL/sec/cm3 0.000000 3 2 S03-06
853 E Liver extraction fraction 0.508507 0.000000 3 2 S03-06
854 Ktrans Hepatic plasma clearance 0.011197 mL/sec/cm3 0.000000 3 2 S03-06
Plot individual results#
Now let’s plot the biomarker values across visits for each study group. For this exercise, let’s specify khe and kbh as the biomarker parameters that we are interested in. For each subject, we can visualise the change in biomarker values between visits. For reference, in the below plots, the studies are numbered as follows: Study 1: Rifampicin repetitive dosing regime Study 2: Cyclosporine repetitive dosing regime Study 3: Bosentan repetitive dosing regime
# Customise plot settings
plt.rcParams["axes.titlesize"] = 25
plt.rcParams["axes.labelsize"] = 20
plt.rcParams["axes.labelweight"] = 'bold'
plt.rcParams["axes.titleweight"] = 'bold'
plt.rcParams["font.weight"] = 'bold'
plt.rc('axes', linewidth=1.5)
plt.rc('xtick', labelsize=15)
plt.rc('ytick', labelsize=15)
plt.rcParams["lines.linewidth"] = 1.5
plt.rcParams['lines.markersize'] = 2
# Extract results of interest, i.e., for parameters khe and kbh
filtered_data = results.query("parameter == 'khe' | parameter == 'kbh'")
# Plot distributions across visits per study groups and per biomarker
g = sns.catplot(data=filtered_data,
x='visit',
y='value',
palette='rocket',
hue='subject',
row='parameter',
col='study',
kind='point',
sharey=False)
g.set_titles(pad=15) # increase white space between subplots and titles
# Set limits for y-axes
for i in range(0, 3):
g.axes[0, i].set(ylim=([0, 0.05]))
for i in range(0, 3):
g.axes[1, i].set(ylim=([0, 0.005]))
g.set_ylabels("Value [mL/sec/cm3]") # set labels for y-axis
# reposition legend
sns.move_legend(g, "lower right", bbox_to_anchor=(0.95, 0.7))
plt.tight_layout()
plt.show()
# Choose the last image as a thumbnail for the gallery
# sphinx_gallery_thumbnail_number = -1
Total running time of the script: (0 minutes 19.928 seconds)