Examples

Kidney applications

Single-kidney glomerular filtration rate

Single-kidney glomerular filtration rate

Liver function: drug effects

A series of preclinical and clinical experiments performed to demonstrate that gadoxetate uptake and excretion rates in liver are biomarkers for drug-induced inhibition of liver function.

Preclinical - repeat dosing effects on liver function

Preclinical - repeat dosing effects on liver function

Clinical - rifampicin induced inhibition (short protocol)

Clinical - rifampicin induced inhibition (short protocol)

Clinical - rifampicin effect in subjects with impaired liver function

Clinical - rifampicin effect in subjects with impaired liver function

Clinical - rifampicin induced inhibition of liver function

Clinical - rifampicin induced inhibition of liver function

Preclinical - reproducibility of hepatocellular function

Preclinical - reproducibility of hepatocellular function

Preclinical - effect on liver function of 6 test drugs

Preclinical - effect on liver function of 6 test drugs

Tutorials

The role of Arterial Input Functions

The role of Arterial Input Functions

An exploration of water exchange effects

An exploration of water exchange effects

Dealing with inflow effects

Dealing with inflow effects

A comparison of convolution functions

A comparison of convolution functions